HOXC5

HOXC5
Identifiers
Aliases	HOXC5, CP11, HOX3, HOX3D, homeobox C5
External IDs	OMIM: 142973 MGI: 96196 HomoloGene: 41296 GeneCards: HOXC5
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q13.13 Start 54,033,050 bp[1] End 54,035,361 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15 F3|15 58.07 cM Start 102,875,878 bp[2] End 102,925,861 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left uterine tube right uterine tube fundus body of stomach popliteal artery tibial nerve subcutaneous adipose tissue right adrenal gland gastric mucosa gastrocnemius muscle Top expressed in superior cervical ganglion urethra male urethra esophagus neural tube yolk sac abdominal wall renal corpuscle trachea stomach More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription factor activity sequence-specific DNA binding DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding Cellular component cell junction nucleus nucleoplasm Biological process regulation of transcription by RNA polymerase II multicellular organism development regulation of transcription, DNA-templated transcription, DNA-templated anterior/posterior pattern specification embryonic skeletal system development positive regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3222 15424 Ensembl ENSG00000172789 ENSMUSG00000022485 UniProt Q00444 P32043 RefSeq (mRNA) NM_018953 NM_175730 RefSeq (protein) NP_061826 NP_783857 Location (UCSC) Chr 12: 54.03 – 54.04 Mb Chr 15: 102.88 – 102.93 Mb PubMed search [3] [4]
Wikidata
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Homeobox protein Hox-C5 is a protein that in humans is encoded by the HOXC5 gene.^[5][6][7]

Function

This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene, HOXC5, is one of several homeobox HOXC genes located in a cluster on chromosome 12. Three genes, HOXC5, HOXC4 and HOXC6, share a 5' non-coding exon. Transcripts may include the shared exon spliced to the gene-specific exons, or they may include only the gene-specific exons. Two alternatively spliced variants have been described for HOXC5. The transcript variant which includes the shared exon apparently doesn't encode a protein. The protein-coding transcript variant contains gene-specific exons only.^[7]

References

Further reading

External links

• HOXC5+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 12 is a stub. You can help Wikipedia by expanding it.

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