Halocortolone

Chemical compound
Halocortolone
Clinical data
Other names9α-Chloro-6α,11β-difluoro-21-hydroxy-16α-methylpregna-1,4-diene-3,20-dione
Drug classCorticosteroid; Glucocorticoid
Identifiers
  • (6S,8S,9R,10S,11S,13S,14S,16R,17S)-9-Chloro-6,11-difluoro-17-(2-hydroxyacetyl)-10,13,16-trimethyl-7,8,11,12,14,15,16,17-octahydro-6H-cyclopenta[a]phenanthren-3-one
CAS Number
  • 24320-27-2
PubChem CID
  • 20056980
ChemSpider
  • 16736630
UNII
  • Z9TL048W82
ChEMBL
  • ChEMBL2106353
Chemical and physical data
FormulaC22H27ClF2O3
Molar mass412.90 g·mol−1
3D model (JSmol)
  • Interactive image
  • C[C@@H]1C[C@H]2[C@@H]3C[C@@H](C4=CC(=O)C=C[C@@]4([C@]3([C@H](C[C@@]2([C@H]1C(=O)CO)C)F)Cl)C)F
InChI
  • InChI=1S/C22H27ClF2O3/c1-11-6-13-14-8-16(24)15-7-12(27)4-5-21(15,3)22(14,23)18(25)9-20(13,2)19(11)17(28)10-26/h4-5,7,11,13-14,16,18-19,26H,6,8-10H2,1-3H3/t11-,13+,14+,16+,18+,19-,20+,21+,22+/m1/s1
  • Key:MBRXSOUHUFBPQC-RFPWEZLHSA-N

Halocortolone is a synthetic glucocorticoid corticosteroid which was never marketed.[1]

References

  1. ^ Elks J (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 618–. ISBN 978-1-4757-2085-3.


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Glucocorticoid receptor modulators
GRTooltip Glucocorticoid receptor
Agonists
  • Nonsteroidal glucocorticoids: AZD-5423
  • GSK-9027
Mixed
(SEGRMsTooltip Selective glucocorticoid receptor agonists)
Antagonists
Others
  • Antisense oligonucleotides: IONIS-GCCRRx (ISIS-426115)
See also
Receptor/signaling modulators
Glucocorticoids and antiglucocorticoids
Mineralocorticoid receptor modulators
List of corticosteroids


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