Hepatoma-derived growth factor

Protein capable of worsening malignant diseases
HDGF
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

1RI0, 2NLU

Identifiers
AliasesHDGF, HMG1L2, hepatoma-derived growth factor, heparin binding growth factor
External IDsOMIM: 600339 MGI: 1194494 HomoloGene: 3306 GeneCards: HDGF
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for HDGF
Genomic location for HDGF
Band1q23.1Start156,742,109 bp[1]
End156,766,925 bp[1]
Gene location (Mouse)
Chromosome 3 (mouse)
Chr.Chromosome 3 (mouse)[2]
Chromosome 3 (mouse)
Genomic location for HDGF
Genomic location for HDGF
Band3 F1|3 38.78 cMStart87,813,628 bp[2]
End87,823,439 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • ganglionic eminence

  • right uterine tube

  • rectum

  • gastrocnemius muscle

  • skin of abdomen

  • monocyte

  • pancreatic ductal cell

  • right lobe of liver

  • gallbladder

  • duodenum
Top expressed in
  • otic placode

  • saccule

  • lip

  • yolk sac

  • morula

  • corneal stroma

  • extensor digitorum longus muscle

  • lens

  • esophagus

  • plantaris muscle
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • nucleotide binding
  • DNA binding
  • transcription corepressor binding
  • transcription corepressor activity
  • growth factor activity
  • heparin binding
  • RNA binding
Cellular component
  • cytoplasm
  • transcription repressor complex
  • nucleus
  • nucleoplasm
  • extracellular space
  • extracellular matrix
  • extracellular region
  • collagen-containing extracellular matrix
Biological process
  • IRE1-mediated unfolded protein response
  • cell population proliferation
  • regulation of transcription, DNA-templated
  • negative regulation of transcription by RNA polymerase II
  • transcription, DNA-templated
  • signal transduction
  • cellular process
  • regulation of signaling receptor activity
  • cellular response to interleukin-7
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

3068

15191

Ensembl

ENSG00000143321

ENSMUSG00000004897

UniProt

P51858

P51859

RefSeq (mRNA)
NM_001126050
NM_001126051
NM_004494
NM_001319186
NM_001319187

NM_001319188

NM_008231
NM_001331051
NM_001331052

RefSeq (protein)
NP_001119522
NP_001119523
NP_001306115
NP_001306116
NP_001306117

NP_004485

NP_001317980
NP_001317981
NP_032257

Location (UCSC)Chr 1: 156.74 – 156.77 MbChr 3: 87.81 – 87.82 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Hepatoma-derived growth factor (HDGF) also known as high mobility group protein 1-like 2 (HMG-1L2) is a protein that in humans is encoded by the HDGF gene.[5][6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000143321 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000004897 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Wanschura S, Schoenmakers EF, Huysmans C, Bartnitzke S, Van de Ven WJ, Bullerdiek J (May 1997). "Mapping of the gene encoding the human hepatoma-derived growth factor (HDGF) with homology to the high-mobility group (HMG)-1 protein to Xq25". Genomics. 32 (2): 298–300. doi:10.1006/geno.1996.0122. PMID 8833162.
  6. ^ "Entrez Gene: HDGF hepatoma-derived growth factor (high-mobility group protein 1-like)".

Further reading

  • Everett AD, Bushweller J (2003). "Hepatoma derived growth factor is a nuclear targeted mitogen". Current Drug Targets. 4 (5): 367–71. doi:10.2174/1389450033490975. PMID 12816346.
  • Nakamura H, Izumoto Y, Kambe H, et al. (1994). "Molecular cloning of complementary DNA for a novel human hepatoma-derived growth factor. Its homology with high mobility group-1 protein". J. Biol. Chem. 269 (40): 25143–9. doi:10.1016/S0021-9258(17)31509-0. PMID 7929202.
  • Kishima Y, Yamamoto H, Izumoto Y, et al. (2002). "Hepatoma-derived growth factor stimulates cell growth after translocation to the nucleus by nuclear localization signals". J. Biol. Chem. 277 (12): 10315–22. doi:10.1074/jbc.M111122200. PMID 11751870.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Mori M, Morishita H, Nakamura H, et al. (2004). "Hepatoma-derived growth factor is involved in lung remodeling by stimulating epithelial growth". Am. J. Respir. Cell Mol. Biol. 30 (4): 459–69. doi:10.1165/rcmb.2003-0013OC. PMID 12972397.
  • Yoshida K, Nakamura H, Okuda Y, et al. (2004). "Expression of hepatoma-derived growth factor in hepatocarcinogenesis". J. Gastroenterol. Hepatol. 18 (11): 1293–301. doi:10.1046/j.1440-1746.2003.03191.x. PMID 14535987. S2CID 24881855.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Shu H, Chen S, Bi Q, et al. (2004). "Identification of phosphoproteins and their phosphorylation sites in the WEHI-231 B lymphoma cell line". Mol. Cell. Proteomics. 3 (3): 279–86. doi:10.1074/mcp.D300003-MCP200. PMID 14729942.
  • Everett AD, Narron JV, Stoops T, et al. (2004). "Hepatoma-derived growth factor is a pulmonary endothelial cell-expressed angiogenic factor". Am. J. Physiol. Lung Cell Mol. Physiol. 286 (6): L1194–201. doi:10.1152/ajplung.00427.2003. PMID 14751852. S2CID 17651256.
  • Sue SC, Chen JY, Huang TH (2004). "Sequence specific 1H, 13C and 15N resonance assignments of the hath-domain of human hepatoma-derived growth factor". J. Biomol. NMR. 29 (1): 95–6. doi:10.1023/B:JNMR.0000019467.57276.05. PMID 15017145. S2CID 84545598.
  • Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
  • Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain". Mol. Cell. Proteomics. 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Shen XY, Zacal N, Singh G, Rainbow AJ (2005). "Alterations in mitochondrial and apoptosis-regulating gene expression in photodynamic therapy-resistant variants of HT29 colon carcinoma cells". Photochem. Photobiol. 81 (2): 306–13. doi:10.1562/2004-07-22-RA-242. PMID 15560738.
  • Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5. Bibcode:2005Sci...307.1621B. doi:10.1126/science.1105776. PMID 15761153. S2CID 39457788.
  • Iwasaki T, Nakagawa K, Nakamura H, et al. (2005). "Hepatoma-derived growth factor as a prognostic marker in completely resected non-small-cell lung cancer". Oncol. Rep. 13 (6): 1075–80. doi:10.3892/or.13.6.1075. PMID 15870924.
  • Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
  • Beranova-Giorgianni S, Zhao Y, Desiderio DM, Giorgianni F (2006). "Phosphoproteomic analysis of the human pituitary". Pituitary. 9 (2): 109–20. doi:10.1007/s11102-006-8916-x. PMID 16807684. S2CID 10789246.
  • Clermont F, Gonzalez NS, Communi D, Franken S, Dumont JE, Robaye B (2008). "HDGF is dephosphorylated during the early steps of endothelial cell apoptosis in a caspase-dependent way". J Cell Biochem. 104 (4): 1161–1171. doi:10.1002/jcb.21788. PMID 18465786. S2CID 8154321.

External links

  • PDBe-KB provides an overview of all the structure information available in the PDB for Human Hepatoma-derived growth factor
  • v
  • t
  • e
  • 1ri0: NMR structure of the N-terminal hath domain of human HDGF
    1ri0: NMR structure of the N-terminal hath domain of human HDGF
  • 2b8a: High Resolution Structure of the HDGF PWWP Domain
    2b8a: High Resolution Structure of the HDGF PWWP Domain
  • v
  • t
  • e
Angiopoietin
  • Kinase inhibitors: Altiratinib
  • CE-245677
  • Rebastinib
CNTF
EGF (ErbB)
EGF
(ErbB1/HER1)
ErbB2/HER2
  • Agonists: Unknown/none
ErbB3/HER3
ErbB4/HER4
FGF
FGFR1
FGFR2
  • Antibodies: Aprutumab
  • Aprutumab ixadotin
FGFR3
FGFR4
Unsorted
HGF (c-Met)
IGF
IGF-1
  • Kinase inhibitors: BMS-754807
  • Linsitinib
  • NVP-ADW742
  • NVP-AEW541
  • OSl-906
IGF-2
  • Antibodies: Dusigitumab
  • Xentuzumab (against IGF-1 and IGF-2)
Others
  • Cleavage products/derivatives with unknown target: Glypromate (GPE, (1-3)IGF-1)
  • Trofinetide
LNGF (p75NTR)
  • Aptamers: Against NGF: RBM-004
  • Decoy receptors: LEVI-04 (p75NTR-Fc)
PDGF
RET (GFL)
GFRα1
GFRα2
GFRα3
GFRα4
Unsorted
  • Kinase inhibitors: Agerafenib
SCF (c-Kit)
TGFβ
  • See here instead.
Trk
TrkA
  • Negative allosteric modulators: VM-902A
  • Aptamers: Against NGF: RBM-004
  • Decoy receptors: ReN-1820 (TrkAd5)
TrkB
TrkC
VEGF
Others


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