Hes family bhlh transcription factor 2

Protein-coding gene in the species Homo sapiens
HES2
Identifiers
AliasesHES2, bHLHb40, hes family bHLH transcription factor 2
External IDsOMIM: 609970 MGI: 1098624 HomoloGene: 22455 GeneCards: HES2
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for HES2
Genomic location for HES2
Band1p36.31Start6,412,418 bp[1]
End6,424,670 bp[1]
Gene location (Mouse)
Chromosome 4 (mouse)
Chr.Chromosome 4 (mouse)[2]
Chromosome 4 (mouse)
Genomic location for HES2
Genomic location for HES2
Band4 E2|4 82.92 cMStart152,243,324 bp[2]
End152,246,926 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • placenta

  • skin of abdomen

  • vagina

  • right uterine tube

  • oral cavity

  • rectum

  • vulva

  • human penis

  • amniotic fluid

  • bronchial epithelial cell
Top expressed in
  • lip

  • jejunum

  • proximal tubule

  • duodenum

  • yolk sac

  • esophagus

  • lens

  • colon

  • stomach

  • zone of skin
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • DNA binding
  • double-stranded DNA binding
  • transcription factor binding
  • protein dimerization activity
  • RNA polymerase II cis-regulatory region sequence-specific DNA binding
  • DNA-binding transcription repressor activity, RNA polymerase II-specific
  • DNA-binding transcription factor activity, RNA polymerase II-specific
  • RNA polymerase II transcription regulatory region sequence-specific DNA binding
  • transcription corepressor activity
  • sequence-specific DNA binding
  • sequence-specific double-stranded DNA binding
Cellular component
  • nucleus
Biological process
  • negative regulation of transcription, DNA-templated
  • regulation of transcription, DNA-templated
  • transcription, DNA-templated
  • negative regulation of transcription by RNA polymerase II
  • somitogenesis
  • Notch signaling pathway
  • cell differentiation
  • regulation of neurogenesis
  • anterior/posterior pattern specification
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

54626

15206

Ensembl

ENSG00000069812

ENSMUSG00000028940

UniProt

Q9Y543

O54792

RefSeq (mRNA)

NM_019089

NM_001301805
NM_008236

RefSeq (protein)

NP_061962

NP_001288734
NP_032262

Location (UCSC)Chr 1: 6.41 – 6.42 MbChr 4: 152.24 – 152.25 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Hes family bHLH transcription factor 2 is a protein that in humans is encoded by the HES2 gene.[5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000069812 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028940 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Hes family bHLH transcription factor 2".

Further reading

  • Nishimura M, Isaka F, Ishibashi M, Tomita K, Tsuda H, Nakanishi S, Kageyama R (April 1998). "Structure, chromosomal locus, and promoter of mouse Hes2 gene, a homologue of Drosophila hairy and Enhancer of split". Genomics. 49 (1): 69–75. doi:10.1006/geno.1998.5213. PMID 9570950.
  • Katoh M, Katoh M (August 2004). "Identification and characterization of human HES2, HES3, and HES5 genes in silico". International Journal of Oncology. 25 (2): 529–34. doi:10.3892/ijo.25.2.529. PMID 15254753.
  • Katoh M, Katoh M (August 2007). "Integrative genomic analyses on HES/HEY family: Notch-independent HES1, HES3 transcription in undifferentiated ES cells, and Notch-dependent HES1, HES5, HEY1, HEY2, HEYL transcription in fetal tissues, adult tissues, or cancer". International Journal of Oncology. 31 (2): 461–6. doi:10.3892/ijo.31.2.461. PMID 17611704.
  • v
  • t
  • e
  • v
  • t
  • e
(1) Basic domains
(1.1) Basic leucine zipper (bZIP)
(1.2) Basic helix-loop-helix (bHLH)
Group A
Group B
Group C
bHLH-PAS
Group D
Group E
Group F
bHLH-COE
(1.3) bHLH-ZIP
(1.4) NF-1
(1.5) RF-X
(1.6) Basic helix-span-helix (bHSH)
(2) Zinc finger DNA-binding domains
(2.1) Nuclear receptor (Cys4)
subfamily 1
subfamily 2
subfamily 3
subfamily 4
subfamily 5
subfamily 6
subfamily 0
(2.2) Other Cys4
(2.3) Cys2His2
(2.4) Cys6
(2.5) Alternating composition
(2.6) WRKY
(3) Helix-turn-helix domains
(3.1) Homeodomain
Antennapedia
ANTP class
protoHOX
Hox-like
metaHOX
NK-like
other
(3.2) Paired box
(3.3) Fork head / winged helix
(3.4) Heat shock factors
(3.5) Tryptophan clusters
(3.6) TEA domain
  • transcriptional enhancer factor
(4) β-Scaffold factors with minor groove contacts
(4.1) Rel homology region
(4.2) STAT
(4.3) p53-like
(4.4) MADS box
(4.6) TATA-binding proteins
(4.7) High-mobility group
(4.9) Grainyhead
(4.10) Cold-shock domain
(4.11) Runt
(0) Other transcription factors
(0.2) HMGI(Y)
(0.3) Pocket domain
(0.5) AP-2/EREBP-related factors
(0.6) Miscellaneous
see also transcription factor/coregulator deficiencies