IFNA4

Protein-coding gene in the species Homo sapiens
IFNA4
Identifiers
AliasesIFNA4, IFN-alpha4a, INFA4, interferon, alpha 4, interferon alpha 4
External IDsOMIM: 147564 MGI: 3649260 HomoloGene: 68536 GeneCards: IFNA4
Gene location (Human)
Chromosome 9 (human)
Chr.Chromosome 9 (human)[1]
Chromosome 9 (human)
Genomic location for IFNA4
Genomic location for IFNA4
Band9p21.3Start21,186,694 bp[1]
End21,187,671 bp[1]
Gene location (Mouse)
Chromosome 4 (mouse)
Chr.Chromosome 4 (mouse)[2]
Chromosome 4 (mouse)
Genomic location for IFNA4
Genomic location for IFNA4
Band4 C4|4Start88,594,152 bp[2]
End88,595,161 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • aorta

  • thoracic aorta

  • ascending aorta
    n/a
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • cytokine activity
  • type I interferon receptor binding
  • protein binding
  • cytokine receptor binding
Cellular component
  • extracellular region
  • extracellular space
Biological process
  • defense response
  • adaptive immune response
  • response to exogenous dsRNA
  • response to virus
  • blood coagulation
  • positive regulation of peptidyl-serine phosphorylation of STAT protein
  • natural killer cell activation involved in immune response
  • B cell proliferation
  • humoral immune response
  • defense response to virus
  • type I interferon signaling pathway
  • B cell differentiation
  • T cell activation involved in immune response
  • cytokine-mediated signaling pathway
  • innate immune response
  • regulation of signaling receptor activity
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

3441

230398

Ensembl

ENSG00000236637

ENSMUSG00000078355

UniProt

P05014

Q810G1

RefSeq (mRNA)

NM_021068

NM_206867

RefSeq (protein)

NP_066546

NP_996750

Location (UCSC)Chr 9: 21.19 – 21.19 MbChr 4: 88.59 – 88.6 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Interferon alpha-4 is a protein that in humans is encoded by the IFNA4 gene.[5][6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000236637 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000078355 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Olopade OI, Bohlander SK, Pomykala H, Maltepe E, Van Melle E, Le Beau MM, Diaz MO (Dec 1992). "Mapping of the shortest region of overlap of deletions of the short arm of chromosome 9 associated with human neoplasia". Genomics. 14 (2): 437–43. doi:10.1016/S0888-7543(05)80238-1. PMID 1385305.
  6. ^ "Entrez Gene: IFNA4 interferon, alpha 4".

Further reading

  • Mizoguchi J, Pitha PM, Raj NB (1985). "Efficient expression in Escherichia coli of two species of human interferon-alpha and their hybrid molecules". DNA. 4 (3): 221–32. doi:10.1089/dna.1985.4.221. PMID 3891272.
  • Henco K, Brosius J, Fujisawa A, et al. (1985). "Structural relationship of human interferon alpha genes and pseudogenes". J. Mol. Biol. 185 (2): 227–60. doi:10.1016/0022-2836(85)90401-2. PMID 4057246.
  • Linnane AW, Beilharz MW, McMullen GL, et al. (1984). "Nucleotide sequence and expression in E. coli of a human interferon-alpha gene selected from a genomic library using synthetic oligonucleotides". Biochem. Int. 8 (5): 725–32. PMID 6089830.
  • Tiefenbrun N, Melamed D, Levy N, et al. (1996). "Alpha interferon suppresses the cyclin D3 and cdc25A genes, leading to a reversible G0-like arrest". Mol. Cell. Biol. 16 (7): 3934–44. doi:10.1128/MCB.16.7.3934. PMC 231390. PMID 8668211.
  • Hussain M, Gill DS, Liao MJ (1997). "Both variant forms of interferon-alpha4 gene (IFNA4a and IFNA4b) are present in the human population". J. Interferon Cytokine Res. 17 (9): 559–66. doi:10.1089/jir.1997.17.559. PMID 9335434.
  • Nyman TA, Tölö H, Parkkinen J, Kalkkinen N (1998). "Identification of nine interferon-alpha subtypes produced by Sendai virus-induced human peripheral blood leucocytes". Biochem. J. 329 (Pt 2): 295–302. doi:10.1042/bj3290295. PMC 1219044. PMID 9425112.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Yokota S, Yokosawa N, Okabayashi T, et al. (2004). "Induction of Suppressor of Cytokine Signaling-3 by Herpes Simplex Virus Type 1 Contributes to Inhibition of the Interferon Signaling Pathway". J. Virol. 78 (12): 6282–6. doi:10.1128/JVI.78.12.6282-6286.2004. PMC 416529. PMID 15163721.
  • Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. Bibcode:2004Natur.429..369H. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.


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