IFNA8

Protein-coding gene in the species Homo sapiens

IFNA8

Identifiers

Aliases

IFNA8, IFN-alphaB, interferon alpha 8

External IDs

OMIM: 147568 HomoloGene: 68237 GeneCards: IFNA8

Gene location (Human)

Chr.	Chromosome 9 (human)^[1]

Band	9p21.3	Start	21,409,117 bp^[1]
Band	9p21.3	End	21,410,185 bp^[1]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

cerebellar cortex

cerebellar hemisphere

prefrontal cortex

n/a

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	cytokine activity type I interferon receptor binding cytokine receptor binding
Cellular component	extracellular region extracellular space
Biological process	natural killer cell activation involved in immune response B cell differentiation defense response B cell proliferation blood coagulation positive regulation of peptidyl-serine phosphorylation of STAT protein humoral immune response adaptive immune response defense response to virus type I interferon signaling pathway response to exogenous dsRNA T cell activation involved in immune response innate immune response cytokine-mediated signaling pathway regulation of signaling receptor activity
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


3445


n/a

Ensembl


ENSG00000120242


n/a

UniProt


P32881


n/a

RefSeq (mRNA)


NM_002170


n/a

RefSeq (protein)


NP_002161


n/a

Location (UCSC)

Chr 9: 21.41 – 21.41 Mb

n/a

PubMed search

^[2]

n/a

Wikidata

View/Edit Human

Interferon alpha-8 is a protein that in humans is encoded by the IFNA8 gene.^[3]^[4]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000120242 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Olopade OI, Bohlander SK, Pomykala H, Maltepe E, Van Melle E, Le Beau MM, Diaz MO (Dec 1992). "Mapping of the shortest region of overlap of deletions of the short arm of chromosome 9 associated with human neoplasia". Genomics. 14 (2): 437–43. doi:10.1016/S0888-7543(05)80238-1. PMID 1385305.
^ "Entrez Gene: IFNA8 interferon, alpha 8".

Henco K, Brosius J, Fujisawa A, et al. (1985). "Structural relationship of human interferon alpha genes and pseudogenes". J. Mol. Biol. 185 (2): 227–60. doi:10.1016/0022-2836(85)90401-2. PMID 4057246.
Goeddel DV, Leung DW, Dull TJ, et al. (1981). "The structure of eight distinct cloned human leukocyte interferon cDNAs". Nature. 290 (5801): 20–6. Bibcode:1981Natur.290...20G. doi:10.1038/290020a0. PMID 6163083. S2CID 1900300.
Yelverton E, Leung D, Weck P, et al. (1981). "Bacterial synthesis of a novel human leukocyte interferon". Nucleic Acids Res. 9 (3): 731–41. doi:10.1093/nar/9.3.731. PMC 327233. PMID 6164048.
Bowden DW, Mao J, Gill T, et al. (1984). "Cloning of eukaryotic genes in single-strand phage vectors: the human interferon genes". Gene. 27 (1): 87–99. doi:10.1016/0378-1119(84)90241-5. PMID 6325303.
Tiefenbrun N, Melamed D, Levy N, et al. (1996). "Alpha interferon suppresses the cyclin D3 and cdc25A genes, leading to a reversible G0-like arrest". Mol. Cell. Biol. 16 (7): 3934–44. doi:10.1128/MCB.16.7.3934. PMC 231390. PMID 8668211.
Hussain M, Gill DS, Liao MJ, Testa D (1997). "Interferon-alpha 8b is the only variant of interferon-alpha 8 identified in a large human population". J. Interferon Cytokine Res. 16 (7): 523–9. doi:10.1089/jir.1996.16.523. PMID 8836918.
Nyman TA, Tölö H, Parkkinen J, Kalkkinen N (1998). "Identification of nine interferon-alpha subtypes produced by Sendai virus-induced human peripheral blood leucocytes". Biochem. J. 329. ( Pt 2) (2): 295–302. doi:10.1042/bj3290295. PMC 1219044. PMID 9425112.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Hardy MP, Owczarek CM, Jermiin LS, et al. (2005). "Characterization of the type I interferon locus and identification of novel genes". Genomics. 84 (2): 331–45. doi:10.1016/j.ygeno.2004.03.003. PMID 15233997.

Cytokine receptor modulators

Chemokine

See here instead.

CSF

Erythropoietin	Agonists: ARA-290 Asialo erythropoietin Carbamylated erythropoietin CNTO-530 Darbepoetin alfa Epoetin alfa Epoetin beta Epoetin delta Epoetin epsilon Epoetin gamma Epoetin kappa Epoetin omega Epoetin theta Epoetin zeta Erythropoietin (EPO) Erythropoietin-Fc Methoxy polyethylene glycol-epoetin beta (CERA/Mircera) Peginesatide Pegol sihematide (EPO-018B)
G-CSF (CSF3)	Agonists: Filgrastim Granulocyte colony-stimulating factor Lenograstim Leridistim Lipegfilgrastim Nartograstim Pegfilgrastim Pegnartograstim
GM-CSF (CSF2)	Agonists: Ecogramostim Granulocyte macrophage colony-stimulating factor Milodistim Molgramostim Regramostim Sargramostim Antibodies: Mavrilimumab Namilumab Otilimab
M-CSF (CSF1)	Agonists: Cilmostim Interleukin-34 Lanimostim Macrophage colony-stimulating factor Mirimostim Kinase inhibitors: Agerafenib
SCF (c-Kit)	See here instead.
Thrombopoietin	Agonists: Eltrombopag Pegacaristim Promegapoietin Romiplostim Thrombopoietin (THPO, MGDF)

Interferon

IFNAR (α/β, I)	Agonists: Albinterferon Interferon alpha (interferon alfa, IFN-α) Interferon alfa (IFNA1, IFNA2, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA21) Interferon alfa 2a Interferon alfa 2b Interferon alfa n1 Interferon alfacon-1 Interferon alpha-n3 Interferon beta (IFN-β) (IFNB1, IFNB3) Interferon beta 1a Interferon beta 1b Interferon kappa (IFN-ε/κ/τ/ζ, IFNK) Interferon omega (IFN-ω, IFNW1) Peginterferon alfa-2a Peginterferon alfa-2b Antibodies: Anifrolumab Faralimomab MEDI-545 Rontalizumab Sifalimumab Decoy receptors: Bifarcept
IFNGR (γ, II)	Agonists: Interferon gamma (IFN-γ) Interferon gamma 1b Antibodies: Emapalumab Fontolizumab
IFNLR (λ, III)	See IL-28R (IFNLR) here instead.

Interleukin

See here instead.

TGFβ

See here instead.

TNF

See here instead.

Others

JAK
(inhibitors)

JAK1	Abrocitinib Baricitinib Filgotinib Momelotinib Oclacitinib Peficitinib Ruxolitinib Tofacitinib (tasocitinib) Upadacitinib
JAK2	Atiprimod AZD-1480 Baricitinib CHZ868 Cucurbitacin I (elatericin B, JSI-124) CYT387 Lestaurtinib NSC-7908 NSC-33994 Pacritinib Peficitinib Ruxolitinib SD-1008 Tofacitinib (tasocitinib)
JAK3	Cercosporamide Decernotinib (VX-509) Peficitinib Ritlecitinib TCS-21311 Tofacitinib (tasocitinib) WHI-P 154 ZM-39923 ZM-449829
TYK2	Deucravacitinib