IKK2

IKBKB
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4KIK, 3BRT, 3BRV, 4E3C
Identifiers
Aliases	IKBKB, IKK-beta, IKK2, IKKB, IMD15, NFKBIKB, inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta, inhibitor of nuclear factor kappa B kinase subunit beta, IMD15A, IMD15B
External IDs	OMIM: 603258 MGI: 1338071 HomoloGene: 7782 GeneCards: IKBKB
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8p11.21 Start 42,271,302 bp[1] End 42,332,460 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8|8 A2 Start 23,149,228 bp[2] End 23,196,605 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in spleen right lobe of thyroid gland right uterine tube skin of abdomen minor salivary glands left lobe of thyroid gland thymus vagina upper lobe of left lung lymph node Top expressed in blood Paneth cell crypt of lieberkuhn of small intestine hair follicle molar medullary collecting duct superior cervical ganglion spleen left lobe of liver urothelium More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity protein kinase activity IkappaB kinase activity nucleotide binding protein homodimerization activity scaffold protein binding kinase activity protein binding ATP binding protein kinase binding protein heterodimerization activity protein serine/threonine kinase activity identical protein binding Cellular component membrane membrane raft CD40 receptor complex cytoplasmic side of plasma membrane nucleus IkappaB kinase complex cytoplasm cytosol Biological process phosphorylation regulation of tumor necrosis factor-mediated signaling pathway cellular response to tumor necrosis factor response to virus regulation of phosphorylation negative regulation of apoptotic process stimulatory C-type lectin receptor signaling pathway T cell receptor signaling pathway TRIF-dependent toll-like receptor signaling pathway Fc-epsilon receptor signaling pathway positive regulation of transcription, DNA-templated protein phosphorylation negative regulation of bicellular tight junction assembly stress-activated MAPK cascade positive regulation of I-kappaB kinase/NF-kappaB signaling negative regulation of myosin-light-chain-phosphatase activity innate immune response inflammatory response I-kappaB kinase/NF-kappaB signaling cortical actin cytoskeleton organization positive regulation of transcription by RNA polymerase II regulation of establishment of endothelial barrier I-kappaB phosphorylation tumor necrosis factor-mediated signaling pathway positive regulation of NF-kappaB transcription factor activity antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent anatomical structure morphogenesis protein localization to plasma membrane MyD88-independent toll-like receptor signaling pathway peptidyl-serine phosphorylation interleukin-1-mediated signaling pathway viral process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3551 16150 Ensembl ENSG00000104365 ENSMUSG00000031537 UniProt O14920 O88351 RefSeq (mRNA) NM_001190720 NM_001190721 NM_001190722 NM_001242778 NM_001556 NM_001159774 NM_010546 RefSeq (protein) NP_001177649 NP_001229707 NP_001547 NP_001153246 NP_034676 Location (UCSC) Chr 8: 42.27 – 42.33 Mb Chr 8: 23.15 – 23.2 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

IKK-β also known as inhibitor of nuclear factor kappa-B kinase subunit beta is a protein that in humans is encoded by the IKBKB (inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta) gene.

Function

IKK-β is an enzyme that serves as a protein subunit of IκB kinase, which is a component of the cytokine-activated intracellular signaling pathway involved in triggering immune responses. IKK's activity causes activation of a transcription factor known as Nuclear Transcription factor kappa-B or NF-κB. Activated IKK-β phosphorylates a protein called the inhibitor of NF-κB, IκB (IκBα), which binds NF-κB to inhibit its function. Phosphorylated IκB is degraded via the ubiquitination pathway, freeing NF-κB, and allowing its entry into the nucleus of the cell where it activates various genes involved in inflammation and other immune responses.

Clinical significance

IKK-β plays a significant role in brain cells following a stroke.^[5] If NF-κB activation by IKK-β is blocked, damaged cells within the brain stay alive, and according to a study performed by the University of Heidelberg and the University of Ulm, the cells even appear to make some recovery.^[6]

Inhibition of IKK and IKK-related kinases has been investigated as a therapeutic option for the treatment of inflammatory diseases and cancer.^[7] The small-molecule inhibitor of IKK2 SAR113945, developed by Sanofi-Aventis, was evaluated in patients with knee osteoarthritis.^[8]

Interactions

IKK-β (IKBKB) has been shown to interact with

References

See also

• IκB kinase