IRAK2

Protein-coding gene in humans
IRAK2
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

3MOP

Identifiers
AliasesIRAK2, IRAK-2, interleukin 1 receptor associated kinase 2
External IDsOMIM: 603304 MGI: 2429603 HomoloGene: 1207 GeneCards: IRAK2
Gene location (Human)
Chromosome 3 (human)
Chr.Chromosome 3 (human)[1]
Chromosome 3 (human)
Genomic location for IRAK2
Genomic location for IRAK2
Band3p25.3Start10,164,919 bp[1]
End10,243,745 bp[1]
Gene location (Mouse)
Chromosome 6 (mouse)
Chr.Chromosome 6 (mouse)[2]
Chromosome 6 (mouse)
Genomic location for IRAK2
Genomic location for IRAK2
Band6 E3|6 52.82 cMStart113,615,428 bp[2]
End113,671,987 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • pancreatic epithelial cell

  • secondary oocyte

  • pancreatic ductal cell

  • palpebral conjunctiva

  • gastrocnemius muscle

  • tibialis anterior muscle

  • amniotic fluid

  • endothelial cell

  • islet of Langerhans

  • right lobe of liver
Top expressed in
  • jejunum

  • urinary bladder

  • white adipose tissue

  • spleen

  • left lung

  • colon

  • proximal tubule

  • duodenum

  • ileum

  • liver
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • nucleotide binding
  • protein kinase activity
  • protein homodimerization activity
  • protein serine/threonine kinase activity
  • protein binding
  • protein heterodimerization activity
  • ATP binding
Cellular component
  • cytoplasm
  • cytosol
  • plasma membrane
  • endosome membrane
  • nucleus
Biological process
  • response to interleukin-1
  • negative regulation of DNA-binding transcription factor activity
  • toll-like receptor signaling pathway
  • protein phosphorylation
  • JNK cascade
  • positive regulation of NF-kappaB transcription factor activity
  • toll-like receptor 9 signaling pathway
  • negative regulation of NF-kappaB transcription factor activity
  • nucleotide-binding oligomerization domain containing signaling pathway
  • lipopolysaccharide-mediated signaling pathway
  • signal transduction
  • regulation of cytokine-mediated signaling pathway
  • I-kappaB kinase/NF-kappaB signaling
  • inflammatory response
  • MyD88-dependent toll-like receptor signaling pathway
  • intracellular signal transduction
  • interleukin-1-mediated signaling pathway
  • cytokine-mediated signaling pathway
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

3656

108960

Ensembl

ENSG00000134070

ENSMUSG00000060477

UniProt

O43187

Q8CFA1

RefSeq (mRNA)

NM_001570

NM_001113553
NM_172161

RefSeq (protein)

NP_001561

NP_001107025
NP_751893

Location (UCSC)Chr 3: 10.16 – 10.24 MbChr 6: 113.62 – 113.67 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Interleukin-1 receptor-associated kinase-like 2 is an enzyme that in humans is encoded by the IRAK2 gene.[5][6]

Function

IRAK2 encodes the interleukin-1 receptor-associated kinase 2, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. IRAK2 is reported to participate in the IL1-induced upregulation of NF-kappaB.[6]

Interactions

IRAK2 has been shown to interact with TRAF6[5][7] and Myd88.[5][7][8]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000134070 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000060477 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b c Muzio M, Ni J, Feng P, Dixit VM (Nov 1997). "IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling". Science. 278 (5343): 1612–5. Bibcode:1997Sci...278.1612M. doi:10.1126/science.278.5343.1612. PMID 9374458.
  6. ^ a b "Entrez Gene: IRAK2 interleukin-1 receptor-associated kinase 2".
  7. ^ a b Wesche H, Gao X, Li X, Kirschning CJ, Stark GR, Cao Z (Jul 1999). "IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family". The Journal of Biological Chemistry. 274 (27): 19403–10. doi:10.1074/jbc.274.27.19403. PMID 10383454.
  8. ^ Fitzgerald KA, Palsson-McDermott EM, Bowie AG, Jefferies CA, Mansell AS, Brady G, Brint E, Dunne A, Gray P, Harte MT, McMurray D, Smith DE, Sims JE, Bird TA, O'Neill LA (Sep 2001). "Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction". Nature. 413 (6851): 78–83. Bibcode:2001Natur.413...78F. doi:10.1038/35092578. PMID 11544529. S2CID 4333764.

Further reading

  • Auron PE (1999). "The interleukin 1 receptor: ligand interactions and signal transduction". Cytokine & Growth Factor Reviews. 9 (3–4): 221–37. doi:10.1016/S1359-6101(98)00018-5. PMID 9918122.
  • Maschera B, Ray K, Burns K, Volpe F (Apr 1999). "Overexpression of an enzymically inactive interleukin-1-receptor-associated kinase activates nuclear factor-kappaB". The Biochemical Journal. 339 ( Pt 2) (2): 227–31. doi:10.1042/0264-6021:3390227. PMC 1220149. PMID 10191251.
  • Wesche H, Gao X, Li X, Kirschning CJ, Stark GR, Cao Z (Jul 1999). "IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family". The Journal of Biological Chemistry. 274 (27): 19403–10. doi:10.1074/jbc.274.27.19403. PMID 10383454.
  • Fitzgerald KA, Palsson-McDermott EM, Bowie AG, Jefferies CA, Mansell AS, Brady G, Brint E, Dunne A, Gray P, Harte MT, McMurray D, Smith DE, Sims JE, Bird TA, O'Neill LA (Sep 2001). "Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction". Nature. 413 (6851): 78–83. Bibcode:2001Natur.413...78F. doi:10.1038/35092578. PMID 11544529. S2CID 4333764.
  • McDermott EP, O'Neill LA (Mar 2002). "Ras participates in the activation of p38 MAPK by interleukin-1 by associating with IRAK, IRAK2, TRAF6, and TAK-1". The Journal of Biological Chemistry. 277 (10): 7808–15. doi:10.1074/jbc.M108133200. hdl:2262/33695. PMID 11744690.
  • Shin BK, Wang H, Yim AM, Le Naour F, Brichory F, Jang JH, Zhao R, Puravs E, Tra J, Michael CW, Misek DE, Hanash SM (Feb 2003). "Global profiling of the cell surface proteome of cancer cells uncovers an abundance of proteins with chaperone function". The Journal of Biological Chemistry. 278 (9): 7607–16. doi:10.1074/jbc.M210455200. PMID 12493773.
  • Bin LH, Xu LG, Shu HB (Jul 2003). "TIRP, a novel Toll/interleukin-1 receptor (TIR) domain-containing adapter protein involved in TIR signaling". The Journal of Biological Chemistry. 278 (27): 24526–32. doi:10.1074/jbc.M303451200. PMID 12721283.
  • Kuzmin I, Geil L, Gibson L, Cavinato T, Loukinov D, Lobanenkov V, Lerman MI (Feb 2005). "Transcriptional regulator CTCF controls human interleukin 1 receptor-associated kinase 2 promoter". Journal of Molecular Biology. 346 (2): 411–22. doi:10.1016/j.jmb.2004.11.066. PMID 15670593.
  • Keating SE, Maloney GM, Moran EM, Bowie AG (Nov 2007). "IRAK-2 participates in multiple toll-like receptor signaling pathways to NFkappaB via activation of TRAF6 ubiquitination". The Journal of Biological Chemistry. 282 (46): 33435–43. doi:10.1074/jbc.M705266200. PMID 17878161.
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