Isopropamide

Chemical compound

A03AB09 (WHO)

Legal statusLegal status

US: ℞-only and Unscheduled
In general: unscheduled

Identifiers

IUPAC name

4-amino-N,N-diisopropyl-N-methyl-4-oxo-3,3-diphenylbutan-1-aminium

CAS Number

7492-32-2^N

PubChem CID

3775

DrugBank

DB01625^Y

ChemSpider

3643^Y

UNII

8B9I31H724

ChEMBL

ChEMBL1201232^N

CompTox Dashboard (EPA)

DTXSID9023174

ECHA InfoCard100.028.470

Chemical and physical dataFormulaC₂₃H₃₃N₂O⁺Molar mass353.530 g·mol⁻¹3D model (JSmol)

Interactive image

SMILES

O=C(N)C(c1ccccc1)(c2ccccc2)CC[N+](C(C)C)(C(C)C)C

InChI

InChI=1S/C23H32N2O/c1-18(2)25(5,19(3)4)17-16-23(22(24)26,20-12-8-6-9-13-20)21-14-10-7-11-15-21/h6-15,18-19H,16-17H2,1-5H3,(H-,24,26)/p+1^Y
Key:JTPUMZTWMWIVPA-UHFFFAOYSA-O^Y

^NY (what is this?) (verify)

Isopropamide (R79) is a long-acting anticholinergic drug. It is used in the treatment of peptic ulcers and other gastrointestinal disorders involving hyperacidity (gastrointestinal acidosis) and hypermotility. Chemically, it contains a quaternary ammonium group. It is most often provided as an iodide salt, but is also available as a bromide or chloride salt. It was discovered at Janssen Pharmaceutica in 1954.

References

Seeherman R (October 1957). "Isopropamide iodide: a long-acting anticholinergic". Delaware Medical Journal. 29 (10): 265–9. PMID 13473394.
Boss Jr EG, Buchanan GC (November 1957). "Effect of isopropamide iodide on basal gastric secretion in the human". Gastroenterology. 33 (5): 730–6. doi:10.1016/S0016-5085(19)35625-2. PMID 13480414.

Drugs for functional gastrointestinal disorders (A03)

Drugs for
functional
bowel
disorders

Antimuscarinics

Tertiary amino group	Oxyphencyclimine Camylofin Mebeverine Trimebutine Rociverine Dicycloverine Dihexyverine Difemerine Piperidolate
Quaternary ammonium compounds	Benzilone Mepenzolate Pipenzolate Glycopyrronium Oxyphenonium Penthienate Methantheline Propantheline Otilonium Tridihexethyl Isopropamide Hexocyclium Poldine Bevonium Diphemanil Tiemonium Prifinium Timepidium Fenpiverinium