Isothipendyl

Chemical compound
  • D04AA22 (WHO) R06AD09 (WHO)
Identifiers
  • N,N-dimethyl-1-(10H-pyrido[3,2-b][1,4]benzothiazin-10-yl)propan-2-amine
CAS Number
  • 482-15-5 1225-65-6
PubChem CID
  • 3781
DrugBank
  • DB08802 checkY
ChemSpider
  • 3649 checkY
UNII
  • WVZ7K9P0JY
KEGG
  • D08091 checkY
CompTox Dashboard (EPA)
  • DTXSID5048267 Edit this at Wikidata
ECHA InfoCard100.006.890 Edit this at WikidataChemical and physical dataFormulaC16H19N3SMolar mass285.41 g·mol−13D model (JSmol)
  • Interactive image
  • n2c1N(c3c(Sc1ccc2)cccc3)CC(N(C)C)C
InChI
  • InChI=1S/C16H19N3S/c1-12(18(2)3)11-19-13-7-4-5-8-14(13)20-15-9-6-10-17-16(15)19/h4-10,12H,11H2,1-3H3 checkY
  • Key:OQJBSDFFQWMKBQ-UHFFFAOYSA-N checkY
  (verify)

Isothipendyl is a 1st generation H1 antagonist (antihistamine) and anticholinergic used as an antipruritic.[1]. In the 2020s, at least, it is rarely used in the first line relief of allergies due to the anticholinergic side effect of somnolence but does have some limited use through topical application in the relief of insect bites and related itching (pruritus).[citation needed]

See also

References

  1. ^ Bibas N, Sartor V, Bulai Livideanu C, Bagheri H, Nougué J, Giordano-Labadie F, et al. (2012). "Contact photoallergy to isothipendyl chlorhydrate". Dermatology. 224 (4): 289–291. doi:10.1159/000338024. PMID 22677929. S2CID 27580642.
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Benzimidazoles (*)DiarylmethanesEthylenediaminesTricyclicsOthers
For topical use
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H1
Agonists
Antagonists
  • Unknown/unsorted: Azanator
  • Belarizine
  • Elbanizine
  • Flotrenizine
  • GSK1004723
  • Napactadine
  • Tagorizine
  • Trelnarizine
  • Trenizine
H2
Agonists
Antagonists
H3
Agonists
Antagonists
H4
Agonists
Antagonists
See also
Receptor/signaling modulators
Monoamine metabolism modulators
Monoamine reuptake inhibitors
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Classes
Antidepressants
(Tricyclic antidepressants (TCAs))
Antihistamines
Antipsychotics
Anticonvulsants
Anticholinergics
Others
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