Josamycin
Chemical compound
- J01FA07 (WHO)
- (2S,3S,4R,6S)-6-{[(2R,3S,4R,5R,6S)-6-{[(4R,5S,6S,7R,9R,10R,11E,13E,16R)-4-Acetoxy-10-hydroxy-5-methoxy-9,16-dimethyl-2-oxo-7-(2-oxoethyl)oxacyclohexadeca-11,13-dien-6-yl]oxy}-4-(dimethylamino)-5-hydro xy-2-methyltetrahydro-2H-pyran-3-yl]oxy}-4-hydroxy-2,4-dimethyltetrahydro-2H-pyran-3-yl 3-methylbutanoate
- 16846-24-5 Y
- 5282165
- DB01321 Y
- 4445361 Y
- HV13HFS217
- D01235 Y
- CHEBI:31739 Y
- ChEMBL224436 Y
- DTXSID8023183
- Interactive image
- C[C@@H]1C/C=C/C=C/[C@@H]([C@@H](C[C@@H]([C@@H]([C@H]([C@@H](CC(=O)O1)OC(=O)C)OC)O[C@H]2[C@@H]([C@H]([C@@H]([C@H](O2)C)O[C@H]3C[C@@]([C@H]([C@@H](O3)C)OC(=O)CC(C)C)(C)O)N(C)C)O)CC=O)C)O
InChI
- InChI=1S/C42H69NO15/c1-23(2)19-32(47)56-40-27(6)53-34(22-42(40,8)50)57-37-26(5)54-41(36(49)35(37)43(9)10)58-38-29(17-18-44)20-24(3)30(46)16-14-12-13-15-25(4)52-33(48)21-31(39(38)51-11)55-28(7)45/h12-14,16,18,23-27,29-31,34-41,46,49-50H,15,17,19-22H2,1-11H3/b13-12+,16-14+/t24-,25-,26-,27+,29+,30+,31-,34+,35-,36-,37-,38+,39+,40+,41+,42-/m1/s1 Y
- Key:XJSFLOJWULLJQS-NGVXBBESSA-N Y
Josamycin is a macrolide antibiotic. It was isolated by Hamao Umezawa and his colleagues from strains of Streptomyces narbonensis var. josamyceticus var. nova in 1964.[1][2]
It is currently sold in various countries.Brand examples are:
- Europe: Josalid, Josacine, Iosalide, Josamina
- Russia: Wilprafen (Вильпрафен)
- Japan: Josamy
Adverse effects
There has been a case report of edema of the feet.[3]
References
- ^ Osono T, Oka Y, Watanabe S, Okami Y, Umezawa H (July 1967). "A new antibiotic, josamyicn. I. Isolation and physico-chemical characteristics". The Journal of Antibiotics. 20 (3): 174–180. PMID 6072798.
- ^ Umezawa H (1982). "Discovery of josamycin". Giornale Italiano di Chemioterapia. 29 (Suppl 1): 1–10. PMID 6765367.
- ^ Bosch X, Pedrol E, Casado X, Urbano-Marquez A (July 1993). "Josamycin-induced pedal oedema". BMJ. 307 (6895): 26. doi:10.1136/bmj.307.6895.26-a. PMC 1678472. PMID 8343666.
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Aminoglycosides (initiation inhibitors) |
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Tetracycline antibiotics (tRNA binding) |
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Steroid antibacterials |
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- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III