Protein-coding gene in the species Homo sapiens
| KCND1 |
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| Identifiers |
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| Aliases | KCND1, KV4.1, potassium voltage-gated channel subfamily D member 1 |
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| External IDs | OMIM: 300281 MGI: 96671 HomoloGene: 21035 GeneCards: KCND1 |
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| Gene location (Human) |
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 | | Chr. | X chromosome (human)[1] |
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| | Band | Xp11.23 | Start | 48,961,378 bp[1] |
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| End | 48,971,844 bp[1] |
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| Gene location (Mouse) |
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 | | Chr. | X chromosome (mouse)[2] |
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| | Band | X A1.1|X 3.53 cM | Start | 7,688,528 bp[2] |
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| End | 7,704,519 bp[2] |
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| RNA expression pattern |
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| Bgee | | Human | Mouse (ortholog) |
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| Top expressed in | - left uterine tube
- stromal cell of endometrium
- ascending aorta
- left coronary artery
- gallbladder
- smooth muscle tissue
- right coronary artery
- gastric mucosa
- prefrontal cortex
- cerebellar vermis
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| | Top expressed in | - facial motor nucleus
- anterior horn of spinal cord
- superior frontal gyrus
- trigeminal ganglion
- calvaria
- submandibular gland
- neural tube
- cerebellar cortex
- renal corpuscle
- yolk sac
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| | More reference expression data |
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| BioGPS |  | | More reference expression data |
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| Gene ontology |
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| Molecular function | - potassium channel activity
- metal ion binding
- voltage-gated ion channel activity
- ion channel activity
- A-type (transient outward) potassium channel activity
- voltage-gated potassium channel activity
| | Cellular component | - integral component of membrane
- cell projection
- membrane
- voltage-gated potassium channel complex
- plasma membrane
- neuronal cell body
- dendrite
- cellular component
| | Biological process | - regulation of ion transmembrane transport
- ion transport
- potassium ion transport
- transmembrane transport
- potassium ion transmembrane transport
- protein homooligomerization
- cardiac conduction
| | Sources:Amigo / QuickGO |
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| Orthologs |
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| Species | Human | Mouse |
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| Entrez | | |
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| Ensembl | | |
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| UniProt | | |
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| RefSeq (mRNA) | | |
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| RefSeq (protein) | | |
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| Location (UCSC) | Chr X: 48.96 – 48.97 Mb | Chr X: 7.69 – 7.7 Mb |
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| PubMed search | [3] | [4] |
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| Wikidata |
| View/Edit Human | View/Edit Mouse |
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Potassium voltage-gated channel, Shal-related subfamily, member 1 (KCND1), also known as Kv4.1, is a human gene.[5]
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shal-related subfamily, members of which form voltage-activated A-type potassium ion channels and are prominent in the repolarization phase of the action potential. This gene is expressed at moderate levels in all tissues analyzed, with lower levels in skeletal muscle.[5]
See also
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000102057 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000009731 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b "Entrez Gene: KCND1 potassium voltage-gated channel, Shal-related subfamily, member 1".
Further reading
- Gutman GA, Chandy KG, Grissmer S, et al. (2006). "International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels". Pharmacol. Rev. 57 (4): 473–508. doi:10.1124/pr.57.4.10. PMID 16382104. S2CID 219195192.
- Kurschner C, Yuzaki M (1999). "Neuronal interleukin-16 (NIL-16): a dual function PDZ domain protein". J. Neurosci. 19 (18): 7770–80. doi:10.1523/JNEUROSCI.19-18-07770.1999. PMC 6782450. PMID 10479680.
- Isbrandt D, Leicher T, Waldschütz R, et al. (2000). "Gene structures and expression profiles of three human KCND (Kv4) potassium channels mediating A-type currents I(TO) and I(SA)". Genomics. 64 (2): 144–54. doi:10.1006/geno.2000.6117. PMID 10729221.
- Nakamura TY, Nandi S, Pountney DJ, et al. (2001). "Different effects of the Ca(2+)-binding protein, KChIP1, on two Kv4 subfamily members, Kv4.1 and Kv4.2". FEBS Lett. 499 (3): 205–9. doi:10.1016/S0014-5793(01)02560-1. PMID 11423117.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Jerng HH, Qian Y, Pfaffinger PJ (2005). "Modulation of Kv4.2 channel expression and gating by dipeptidyl peptidase 10 (DPP10)". Biophys. J. 87 (4): 2380–96. doi:10.1529/biophysj.104.042358. PMC 1304660. PMID 15454437.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Kim SJ, Choi WS, Han JS, et al. (2005). "A novel mechanism for the suppression of a voltage-gated potassium channel by glucose-dependent insulinotropic polypeptide: protein kinase A-dependent endocytosis". J. Biol. Chem. 280 (31): 28692–700. doi:10.1074/jbc.M504913200. PMID 15955806.
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