KCNF1

Protein-coding gene in the species Homo sapiens

KCNF1

Identifiers

Aliases

KCNF1, IK8, KCNF, KV5.1, kH1, potassium voltage-gated channel modifier subfamily F member 1

External IDs

OMIM: 603787 MGI: 2687399 HomoloGene: 124236 GeneCards: KCNF1

Gene location (Human)

Chr.	Chromosome 2 (human)^[1]

Band	2p25.1	Start	10,911,934 bp^[1]
Band	2p25.1	End	10,914,225 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 12 (mouse)^[2]

Band	12\|12 A1.1	Start	17,222,101 bp^[2]
Band	12\|12 A1.1	End	17,226,889 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

prefrontal cortex

putamen

nucleus accumbens

caudate nucleus

cingulate gyrus

dorsolateral prefrontal cortex

Brodmann area 9

orbitofrontal cortex

Brodmann area 10

superior frontal gyrus

Top expressed in

temporal lobe

prefrontal cortex

amygdala

piriform cortex

olfactory bulb

superior frontal gyrus

supraoptic nucleus

nucleus accumbens

primary motor cortex

cingulate gyrus

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	ion channel activity potassium channel activity voltage-gated ion channel activity voltage-gated potassium channel activity
Cellular component	integral component of membrane voltage-gated potassium channel complex plasma membrane membrane
Biological process	potassium ion transport regulation of ion transmembrane transport protein homooligomerization ion transport transmembrane transport potassium ion transmembrane transport
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


3754


382571

Ensembl


ENSG00000162975


ENSMUSG00000051726

UniProt


Q9H3M0


Q7TSH7

RefSeq (mRNA)


NM_002236


NM_201531

RefSeq (protein)


NP_002227


NP_963289

Location (UCSC)

Chr 2: 10.91 – 10.91 Mb

Chr 12: 17.22 – 17.23 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Potassium voltage-gated channel subfamily F member 1 is a protein that in humans is encoded by the KCNF1 gene.^[5]^[6] The protein encoded by this gene is a voltage-gated potassium channel subunit.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000162975 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000051726 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Su K, Kyaw H, Fan P, Zeng Z, Shell BK, Carter KC, Li Y (Feb 1998). "Isolation, characterization, and mapping of two human potassium channels". Biochem Biophys Res Commun. 241 (3): 675–81. doi:10.1006/bbrc.1997.7830. PMID 9434767.
^ ^a ^b Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stuhmer W, Wang X (Dec 2005). "International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels". Pharmacol Rev. 57 (4): 473–508. doi:10.1124/pr.57.4.10. PMID 16382104. S2CID 219195192.

External links

Kv3.2+Potassium+Channel at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
KCNB2+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

Membrane transport protein: ion channels (TC 1A)

Ca²⁺: Calcium channel

Ligand-gated	Inositol trisphosphate receptor 1 2 3 Ryanodine receptor 1 2 3
Voltage-gated	L-type/Ca_vα 1.1 1.2 1.3 1.4 N-type/Ca_vα2.2 P-type/Ca_vα 2.1 Q-type/Ca_vα2.1 R-type/Ca_vα2.3 T-type/Ca_vα 3.1 3.2 3.3 α₂δ-subunits 1 2 β-subunits β1 β2 β3 β4 γ-subunits γ1 γ2 γ3 γ4 Cation channels of sperm 1 2 3 4 Two-pore channel 1 2

Na⁺: Sodium channel

Constitutively active	Epithelial sodium channel α β γ δ
Proton-gated	Amiloride-sensitive cation channel 1 2 3 4
Voltage-gated	Na_vα 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 1.9 7A Na_vβ 1 2 3 4

K⁺: Potassium channel

Calcium-activated	BK channel α1 β1 β2 β3 β4 SK channel SK1 SK2 SK3 IK channel IK1 K_Ca 1.1 2.1 2.2 2.3 3.1 4.1 4.2 5.1
Inward-rectifier	K_ATP K_ir 1.1 2.1 2.2 2.3 2.4 2.6 GIRK/K_ir 3.1 3.2 3.3 3.4 K_ir 4.1 4.2 5.1 6.1 6.2 7.1
Tandem pore domain	K2P 1 2 3 4 5 6 7 9 10 12 13 15 16 17 18
Voltage-gated	K_vα1-6 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 2.1 2.2 3.1 3.2 3.3 3.4 4.1 4.2 4.3 5.1 6.1 6.2 6.3 6.4 K_vα7-12 7.1 7.2 7.3 7.4 7.5 8.1 8.2 9.1 9.2 9.3 10.1 10.2 11.1/hERG 11.2 11.3 12.1 12.2 12.3 K_vβ 1 2 3 KCNIP 1 2 3 4 minK/ISK minK/ISK-like MiRP 1 2 3 Shaker (gene)

Miscellaneous

Cl⁻: Chloride channel	Calcium-activated chloride channels Anoctamin ANO1 Bestrophin 1 2 Chloride Channel Accessory 1 2 3 4 CFTR CLCN 1 2 3 4 5 6 7 KA KB CLIC 1 2 3 4 5 6 L1 CLNS 1A 1B
H⁺: Proton channel	HVCN1
M⁺: CNG cation channel	α 1 2 3 4 β 1 2 3 HCN FC 1 2 3 4
M⁺: TRP cation channel	TRPA (1) TRPC 1 2 3 4 4AP 5 6 7 TRPM 1 2 3 4 5 6 7 8 TRPML 1 2 3 TRPN TRPP 1 2 TRPV 1 2 3 4 5 6
H₂O (+ solutes): Porin	Aquaporin 0 1 2 3 4 5 6 7 8 9 Voltage-dependent anion channel 1 2 3 General bacterial porin family
Cytoplasm: Gap junction	Connexin A GJA1 GJA3 GJA4 GJA5 GJA8 GJA9 GJA10 B GJB1 GJB2 GJB3 GJB4 GJB5 GJB6 GJB7 C GJC1 GJC2 GJC3 D GJD2 GJD3 GJD4 Innexin