KCNG4

Protein-coding gene in the species Homo sapiens

KCNG4

Identifiers

Aliases

KCNG4, KV6.3, KV6.4, potassium voltage-gated channel modifier subfamily G member 4

External IDs

OMIM: 607603 MGI: 1913983 HomoloGene: 23553 GeneCards: KCNG4

Gene location (Human)

Chr.	Chromosome 16 (human)^[1]

Band	16q24.1	Start	84,218,657 bp^[1]
Band	16q24.1	End	84,240,012 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 8 (mouse)^[2]

Band	8\|8 E1	Start	120,350,593 bp^[2]
Band	8\|8 E1	End	120,362,419 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

amygdala

substantia nigra

hypothalamus

prefrontal cortex

hippocampus proper

putamen

nucleus accumbens

caudate nucleus

dorsolateral prefrontal cortex

cerebellum

Top expressed in

facial motor nucleus

cerebellar cortex

knee joint

vastus lateralis muscle

habenula

triceps brachii muscle

temporal muscle

cerebellar vermis

anterior horn of spinal cord

tibialis anterior muscle

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	voltage-gated potassium channel activity ion channel activity potassium channel activity delayed rectifier potassium channel activity transmembrane transporter binding voltage-gated ion channel activity
Cellular component	integral component of membrane voltage-gated potassium channel complex plasma membrane membrane
Biological process	potassium ion transport regulation of ion transmembrane transport protein homooligomerization ion transport transmembrane transport potassium ion transmembrane transport
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


93107


66733

Ensembl


ENSG00000168418


ENSMUSG00000045246

UniProt


Q8TDN1


Q80XM3

RefSeq (mRNA)


NM_172347 NM_133490


NM_025734 NM_001357210

RefSeq (protein)


NP_758857


NP_080010 NP_001344139

Location (UCSC)

Chr 16: 84.22 – 84.24 Mb

Chr 8: 120.35 – 120.36 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Potassium voltage-gated channel subfamily G member 4 is a protein that in humans is encoded by the KCNG4 gene.^[5]^[6] The protein encoded by this gene is a voltage-gated potassium channel subunit.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000168418 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000045246 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Ottschytsch N, Raes A, Van Hoorick D, Snyders DJ (Jun 2002). "Obligatory heterotetramerization of three previously uncharacterized Kv channel alpha-subunits identified in the human genome". Proc Natl Acad Sci U S A. 99 (12): 7986–91. Bibcode:2002PNAS...99.7986O. doi:10.1073/pnas.122617999. PMC 123007. PMID 12060745.
^ ^a ^b Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stuhmer W, Wang X (Dec 2005). "International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels". Pharmacol Rev. 57 (4): 473–508. doi:10.1124/pr.57.4.10. PMID 16382104. S2CID 219195192.

External links

Kv6.4+Potassium+Channel at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
KCNG4+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

Membrane transport protein: ion channels (TC 1A)

Ca²⁺: Calcium channel

Ligand-gated	Inositol trisphosphate receptor 1 2 3 Ryanodine receptor 1 2 3
Voltage-gated	L-type/Ca_vα 1.1 1.2 1.3 1.4 N-type/Ca_vα2.2 P-type/Ca_vα 2.1 Q-type/Ca_vα2.1 R-type/Ca_vα2.3 T-type/Ca_vα 3.1 3.2 3.3 α₂δ-subunits 1 2 β-subunits β1 β2 β3 β4 γ-subunits γ1 γ2 γ3 γ4 Cation channels of sperm 1 2 3 4 Two-pore channel 1 2

Na⁺: Sodium channel

Constitutively active	Epithelial sodium channel α β γ δ
Proton-gated	Amiloride-sensitive cation channel 1 2 3 4
Voltage-gated	Na_vα 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 1.9 7A Na_vβ 1 2 3 4

K⁺: Potassium channel

Calcium-activated	BK channel α1 β1 β2 β3 β4 SK channel SK1 SK2 SK3 IK channel IK1 K_Ca 1.1 2.1 2.2 2.3 3.1 4.1 4.2 5.1
Inward-rectifier	K_ATP K_ir 1.1 2.1 2.2 2.3 2.4 2.6 GIRK/K_ir 3.1 3.2 3.3 3.4 K_ir 4.1 4.2 5.1 6.1 6.2 7.1
Tandem pore domain	K2P 1 2 3 4 5 6 7 9 10 12 13 15 16 17 18
Voltage-gated	K_vα1-6 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 2.1 2.2 3.1 3.2 3.3 3.4 4.1 4.2 4.3 5.1 6.1 6.2 6.3 6.4 K_vα7-12 7.1 7.2 7.3 7.4 7.5 8.1 8.2 9.1 9.2 9.3 10.1 10.2 11.1/hERG 11.2 11.3 12.1 12.2 12.3 K_vβ 1 2 3 KCNIP 1 2 3 4 minK/ISK minK/ISK-like MiRP 1 2 3 Shaker (gene)

Miscellaneous

Cl⁻: Chloride channel	Calcium-activated chloride channels Anoctamin ANO1 Bestrophin 1 2 Chloride Channel Accessory 1 2 3 4 CFTR CLCN 1 2 3 4 5 6 7 KA KB CLIC 1 2 3 4 5 6 L1 CLNS 1A 1B
H⁺: Proton channel	HVCN1
M⁺: CNG cation channel	α 1 2 3 4 β 1 2 3 HCN FC 1 2 3 4
M⁺: TRP cation channel	TRPA (1) TRPC 1 2 3 4 4AP 5 6 7 TRPM 1 2 3 4 5 6 7 8 TRPML 1 2 3 TRPN TRPP 1 2 TRPV 1 2 3 4 5 6
H₂O (+ solutes): Porin	Aquaporin 0 1 2 3 4 5 6 7 8 9 Voltage-dependent anion channel 1 2 3 General bacterial porin family
Cytoplasm: Gap junction	Connexin A GJA1 GJA3 GJA4 GJA5 GJA8 GJA9 GJA10 B GJB1 GJB2 GJB3 GJB4 GJB5 GJB6 GJB7 C GJC1 GJC2 GJC3 D GJD2 GJD3 GJD4 Innexin