KCNH4

Protein-coding gene in the species Homo sapiens

KCNH4

Identifiers

Aliases

KCNH4, BEC2, ELK1, Kv12.3, potassium voltage-gated channel subfamily H member 4

External IDs

OMIM: 604528 MGI: 2156184 HomoloGene: 8180 GeneCards: KCNH4

Gene location (Human)

Chr.	Chromosome 17 (human)^[1]

Band	17q21.2	Start	42,156,891 bp^[1]
Band	17q21.2	End	42,181,142 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 11 (mouse)^[2]

Band	11 D\|11 63.57 cM	Start	100,631,202 bp^[2]
Band	11 D\|11 63.57 cM	End	100,650,768 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

putamen

caudate nucleus

nucleus accumbens

prefrontal cortex

Brodmann area 9

appendix

amygdala

urinary bladder

hypothalamus

lymph node

Top expressed in

superior frontal gyrus

mesencephalon

olfactory bulb

neural tube

ganglionic eminence

hypothalamus

rhombencephalon

hippocampus proper

white adipose tissue

kidney

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	voltage-gated ion channel activity ion channel activity phosphorelay sensor kinase activity potassium channel activity voltage-gated potassium channel activity
Cellular component	integral component of membrane intracellular anatomical structure plasma membrane voltage-gated potassium channel complex membrane integral component of plasma membrane
Biological process	ion transport phosphorelay signal transduction system signal transduction potassium ion transmembrane transport potassium ion transport regulation of ion transmembrane transport transmembrane transport regulation of membrane potential
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


23415


380728

Ensembl


ENSG00000089558


ENSMUSG00000035355

UniProt


Q9UQ05


A2A5F7

RefSeq (mRNA)


NM_012285


NM_001081194

RefSeq (protein)


NP_036417


NP_001074663

Location (UCSC)

Chr 17: 42.16 – 42.18 Mb

Chr 11: 100.63 – 100.65 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Potassium voltage-gated channel subfamily H member 4 is a protein that in humans is encoded by the KCNH4 gene.^[5]^[6] The protein encoded by this gene is a voltage-gated potassium channel subunit.^[5]^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000089558 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000035355 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b Miyake A, Mochizuki S, Yokoi H, Kohda M, Furuichi K (Sep 1999). "New ether-a-go-go K(+) channel family members localized in human telencephalon". J Biol Chem. 274 (35): 25018–25. doi:10.1074/jbc.274.35.25018. PMID 10455180.
^ ^a ^b Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stuhmer W, Wang X (Dec 2005). "International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels". Pharmacol Rev. 57 (4): 473–508. doi:10.1124/pr.57.4.10. PMID 16382104. S2CID 219195192.

External links

Kv12.3+Potassium+Channel at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
KCNH4+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

Membrane transport protein: ion channels (TC 1A)

Ca²⁺: Calcium channel

Ligand-gated	Inositol trisphosphate receptor 1 2 3 Ryanodine receptor 1 2 3
Voltage-gated	L-type/Ca_vα 1.1 1.2 1.3 1.4 N-type/Ca_vα2.2 P-type/Ca_vα 2.1 Q-type/Ca_vα2.1 R-type/Ca_vα2.3 T-type/Ca_vα 3.1 3.2 3.3 α₂δ-subunits 1 2 β-subunits β1 β2 β3 β4 γ-subunits γ1 γ2 γ3 γ4 Cation channels of sperm 1 2 3 4 Two-pore channel 1 2

Na⁺: Sodium channel

Constitutively active	Epithelial sodium channel α β γ δ
Proton-gated	Amiloride-sensitive cation channel 1 2 3 4
Voltage-gated	Na_vα 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 1.9 7A Na_vβ 1 2 3 4

K⁺: Potassium channel

Calcium-activated	BK channel α1 β1 β2 β3 β4 SK channel SK1 SK2 SK3 IK channel IK1 K_Ca 1.1 2.1 2.2 2.3 3.1 4.1 4.2 5.1
Inward-rectifier	K_ATP K_ir 1.1 2.1 2.2 2.3 2.4 2.6 GIRK/K_ir 3.1 3.2 3.3 3.4 K_ir 4.1 4.2 5.1 6.1 6.2 7.1
Tandem pore domain	K2P 1 2 3 4 5 6 7 9 10 12 13 15 16 17 18
Voltage-gated	K_vα1-6 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 2.1 2.2 3.1 3.2 3.3 3.4 4.1 4.2 4.3 5.1 6.1 6.2 6.3 6.4 K_vα7-12 7.1 7.2 7.3 7.4 7.5 8.1 8.2 9.1 9.2 9.3 10.1 10.2 11.1/hERG 11.2 11.3 12.1 12.2 12.3 K_vβ 1 2 3 KCNIP 1 2 3 4 minK/ISK minK/ISK-like MiRP 1 2 3 Shaker (gene)

Miscellaneous

Cl⁻: Chloride channel	Calcium-activated chloride channels Anoctamin ANO1 Bestrophin 1 2 Chloride Channel Accessory 1 2 3 4 CFTR CLCN 1 2 3 4 5 6 7 KA KB CLIC 1 2 3 4 5 6 L1 CLNS 1A 1B
H⁺: Proton channel	HVCN1
M⁺: CNG cation channel	α 1 2 3 4 β 1 2 3 HCN FC 1 2 3 4
M⁺: TRP cation channel	TRPA (1) TRPC 1 2 3 4 4AP 5 6 7 TRPM 1 2 3 4 5 6 7 8 TRPML 1 2 3 TRPN TRPP 1 2 TRPV 1 2 3 4 5 6
H₂O (+ solutes): Porin	Aquaporin 0 1 2 3 4 5 6 7 8 9 Voltage-dependent anion channel 1 2 3 General bacterial porin family
Cytoplasm: Gap junction	Connexin A GJA1 GJA3 GJA4 GJA5 GJA8 GJA9 GJA10 B GJB1 GJB2 GJB3 GJB4 GJB5 GJB6 GJB7 C GJC1 GJC2 GJC3 D GJD2 GJD3 GJD4 Innexin