KCNH6

Protein-coding gene in the species Homo sapiens

KCNH6

Identifiers

Aliases

KCNH6, ERG-2, ERG2, HERG2, Kv11.2, hERG-2, potassium voltage-gated channel subfamily H member 6

External IDs

OMIM: 608168 MGI: 2684139 HomoloGene: 32740 GeneCards: KCNH6

Gene location (Human)

Chr.	Chromosome 17 (human)^[1]

Band	17q23.3	Start	63,523,334 bp^[1]
Band	17q23.3	End	63,548,977 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 11 (mouse)^[2]

Band	11\|11 E1	Start	106,008,124 bp^[2]
Band	11\|11 E1	End	106,034,549 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

kidney

anterior pituitary

islet of Langerhans

jejunal mucosa

prostate

duodenum

renal medulla

renal cortex

kidney tubule

hypothalamus

Top expressed in

islet of Langerhans

optic nerve

granular layer

Purkinje cell

inferior colliculus

hypothalamus

pontine nuclei

atrium

internal granular layer

neural tube

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	voltage-gated potassium channel activity ion channel activity potassium channel activity voltage-gated ion channel activity
Cellular component	integral component of membrane plasma membrane membrane integral component of plasma membrane
Biological process	regulation of membrane potential potassium ion transport regulation of ion transmembrane transport ion transport transmembrane transport potassium ion transmembrane transport regulation of heart rate by cardiac conduction
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


81033


192775

Ensembl


ENSG00000173826


ENSMUSG00000001901

UniProt


Q9H252


n/a

RefSeq (mRNA)


NM_001278919 NM_001278920 NM_030779 NM_173092


NM_001037712

RefSeq (protein)


NP_001265848 NP_001265849 NP_110406 NP_775115


n/a

Location (UCSC)

Chr 17: 63.52 – 63.55 Mb

Chr 11: 106.01 – 106.03 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Potassium voltage-gated channel subfamily H member 6 is a protein that in humans is encoded by the KCNH6 gene.^[5] The protein encoded by this gene is a voltage-gated potassium channel subunit.^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000173826 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000001901 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stuhmer W, Wang X (Dec 2005). "International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels". Pharmacol Rev. 57 (4): 473–508. doi:10.1124/pr.57.4.10. PMID 16382104. S2CID 219195192.

External links

Kv11.2+Potassium+Channel at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
KCNH6+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

Membrane transport protein: ion channels (TC 1A)

Ca²⁺: Calcium channel

Ligand-gated	Inositol trisphosphate receptor 1 2 3 Ryanodine receptor 1 2 3
Voltage-gated	L-type/Ca_vα 1.1 1.2 1.3 1.4 N-type/Ca_vα2.2 P-type/Ca_vα 2.1 Q-type/Ca_vα2.1 R-type/Ca_vα2.3 T-type/Ca_vα 3.1 3.2 3.3 α₂δ-subunits 1 2 β-subunits β1 β2 β3 β4 γ-subunits γ1 γ2 γ3 γ4 Cation channels of sperm 1 2 3 4 Two-pore channel 1 2

Na⁺: Sodium channel

Constitutively active	Epithelial sodium channel α β γ δ
Proton-gated	Amiloride-sensitive cation channel 1 2 3 4
Voltage-gated	Na_vα 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 1.9 7A Na_vβ 1 2 3 4

K⁺: Potassium channel

Calcium-activated	BK channel α1 β1 β2 β3 β4 SK channel SK1 SK2 SK3 IK channel IK1 K_Ca 1.1 2.1 2.2 2.3 3.1 4.1 4.2 5.1
Inward-rectifier	K_ATP K_ir 1.1 2.1 2.2 2.3 2.4 2.6 GIRK/K_ir 3.1 3.2 3.3 3.4 K_ir 4.1 4.2 5.1 6.1 6.2 7.1
Tandem pore domain	K2P 1 2 3 4 5 6 7 9 10 12 13 15 16 17 18
Voltage-gated	K_vα1-6 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 2.1 2.2 3.1 3.2 3.3 3.4 4.1 4.2 4.3 5.1 6.1 6.2 6.3 6.4 K_vα7-12 7.1 7.2 7.3 7.4 7.5 8.1 8.2 9.1 9.2 9.3 10.1 10.2 11.1/hERG 11.2 11.3 12.1 12.2 12.3 K_vβ 1 2 3 KCNIP 1 2 3 4 minK/ISK minK/ISK-like MiRP 1 2 3 Shaker (gene)

Miscellaneous

Cl⁻: Chloride channel	Calcium-activated chloride channels Anoctamin ANO1 Bestrophin 1 2 Chloride Channel Accessory 1 2 3 4 CFTR CLCN 1 2 3 4 5 6 7 KA KB CLIC 1 2 3 4 5 6 L1 CLNS 1A 1B
H⁺: Proton channel	HVCN1
M⁺: CNG cation channel	α 1 2 3 4 β 1 2 3 HCN FC 1 2 3 4
M⁺: TRP cation channel	TRPA (1) TRPC 1 2 3 4 4AP 5 6 7 TRPM 1 2 3 4 5 6 7 8 TRPML 1 2 3 TRPN TRPP 1 2 TRPV 1 2 3 4 5 6
H₂O (+ solutes): Porin	Aquaporin 0 1 2 3 4 5 6 7 8 9 Voltage-dependent anion channel 1 2 3 General bacterial porin family
Cytoplasm: Gap junction	Connexin A GJA1 GJA3 GJA4 GJA5 GJA8 GJA9 GJA10 B GJB1 GJB2 GJB3 GJB4 GJB5 GJB6 GJB7 C GJC1 GJC2 GJC3 D GJD2 GJD3 GJD4 Innexin