KCNMB4

Protein-coding gene in humans

KCNMB4

Identifiers

Aliases

KCNMB4, potassium calcium-activated channel subfamily M regulatory beta subunit 4

External IDs

OMIM: 605223 MGI: 1913272 HomoloGene: 8721 GeneCards: KCNMB4

Gene location (Human)

Chr.	Chromosome 12 (human)^[1]

Band	12q15	Start	70,366,290 bp^[1]
Band	12q15	End	70,434,292 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 10 (mouse)^[2]

Band	10\|10 D2	Start	116,253,766 bp^[2]
Band	10\|10 D2	End	116,309,783 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

endothelial cell

postcentral gyrus

entorhinal cortex

hippocampus proper

corpus callosum

superior frontal gyrus

middle temporal gyrus

external globus pallidus

prefrontal cortex

internal globus pallidus

Top expressed in

primary motor cortex

cingulate gyrus

facial motor nucleus

cerebellar vermis

globus pallidus

medial dorsal nucleus

spermatocyte

prefrontal cortex

habenula

supraoptic nucleus

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	protein binding calcium-activated potassium channel activity potassium channel regulator activity
Cellular component	integral component of membrane integral component of plasma membrane plasma membrane voltage-gated potassium channel complex membrane
Biological process	ion transport action potential neuronal action potential regulation of vasoconstriction chemical synaptic transmission detection of calcium ion potassium ion transport regulation of neurotransmitter secretion potassium ion transmembrane transport
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


27345


58802

Ensembl


ENSG00000135643


ENSMUSG00000054934

UniProt


Q86W47


Q9JIN6

RefSeq (mRNA)


NM_014505


NM_021452

RefSeq (protein)


NP_055320


NP_067427

Location (UCSC)

Chr 12: 70.37 – 70.43 Mb

Chr 10: 116.25 – 116.31 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Calcium-activated potassium channel subunit beta-4 is a protein that in humans is encoded by the KCNMB4 gene.^[5]^[6]^[7]

MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the modulatory beta subunit. The protein encoded by this gene is an auxiliary beta subunit which slows activation kinetics, leads to steeper calcium sensitivity, and shifts the voltage range of current activation to more negative potentials than does the beta 1 subunit.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000135643 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000054934 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Brenner R, Jegla TJ, Wickenden A, Liu Y, Aldrich RW (Apr 2000). "Cloning and functional characterization of novel large conductance calcium-activated potassium channel beta subunits, hKCNMB3 and hKCNMB4". J Biol Chem. 275 (9): 6453–61. doi:10.1074/jbc.275.9.6453. PMID 10692449.
^ Behrens R, Nolting A, Reimann F, Schwarz M, Waldschutz R, Pongs O (Jul 2000). "hKCNMB3 and hKCNMB4, cloning and characterization of two members of the large-conductance calcium-activated potassium channel beta subunit family". FEBS Lett. 474 (1): 99–106. doi:10.1016/S0014-5793(00)01584-2. PMID 10828459. S2CID 32791798.
^ ^a ^b "Entrez Gene: KCNMB4 potassium large conductance calcium-activated channel, subfamily M, beta member 4".

Orio P, Rojas P, Ferreira G, Latorre R (2002). "New disguises for an old channel: MaxiK channel beta-subunits". News Physiol. Sci. 17 (4): 156–61. doi:10.1152/nips.01387.2002. hdl:10533/173696. PMID 12136044.
Liu QH, Williams DA, McManus C, et al. (2000). "HIV-1 gp120 and chemokines activate ion channels in primary macrophages through CCR5 and CXCR4 stimulation". Proc. Natl. Acad. Sci. U.S.A. 97 (9): 4832–7. Bibcode:2000PNAS...97.4832L. doi:10.1073/pnas.090521697. PMC 18318. PMID 10758170.
Meera P, Wallner M, Toro L (2000). "A neuronal β subunit (KCNMB4) makes the large conductance, voltage- and Ca2+-activated K+ channel resistant to charybdotoxin and iberiotoxin". Proc. Natl. Acad. Sci. U.S.A. 97 (10): 5562–7. Bibcode:2000PNAS...97.5562M. doi:10.1073/pnas.100118597. PMC 25868. PMID 10792058.
Weiger TM, Holmqvist MH, Levitan IB, et al. (2000). "A novel nervous system beta subunit that downregulates human large conductance calcium-dependent potassium channels". J. Neurosci. 20 (10): 3563–70. doi:10.1523/JNEUROSCI.20-10-03563.2000. PMC 6772688. PMID 10804197.
Jin P, Weiger TM, Wu Y, Levitan IB (2002). "Phosphorylation-dependent functional coupling of hSlo calcium-dependent potassium channel and its hbeta 4 subunit". J. Biol. Chem. 277 (12): 10014–20. doi:10.1074/jbc.M107682200. PMID 11790768.
Jin P, Weiger TM, Levitan IB (2003). "Reciprocal modulation between the alpha and beta 4 subunits of hSlo calcium-dependent potassium channels". J. Biol. Chem. 277 (46): 43724–9. doi:10.1074/jbc.M205795200. PMID 12223479.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Membrane transport protein: ion channels (TC 1A)

Ca²⁺: Calcium channel

Ligand-gated	Inositol trisphosphate receptor 1 2 3 Ryanodine receptor 1 2 3
Voltage-gated	L-type/Ca_vα 1.1 1.2 1.3 1.4 N-type/Ca_vα2.2 P-type/Ca_vα 2.1 Q-type/Ca_vα2.1 R-type/Ca_vα2.3 T-type/Ca_vα 3.1 3.2 3.3 α₂δ-subunits 1 2 β-subunits β1 β2 β3 β4 γ-subunits γ1 γ2 γ3 γ4 Cation channels of sperm 1 2 3 4 Two-pore channel 1 2

Na⁺: Sodium channel

Constitutively active	Epithelial sodium channel α β γ δ
Proton-gated	Amiloride-sensitive cation channel 1 2 3 4
Voltage-gated	Na_vα 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 1.9 7A Na_vβ 1 2 3 4

K⁺: Potassium channel

Calcium-activated	BK channel α1 β1 β2 β3 β4 SK channel SK1 SK2 SK3 IK channel IK1 K_Ca 1.1 2.1 2.2 2.3 3.1 4.1 4.2 5.1
Inward-rectifier	K_ATP K_ir 1.1 2.1 2.2 2.3 2.4 2.6 GIRK/K_ir 3.1 3.2 3.3 3.4 K_ir 4.1 4.2 5.1 6.1 6.2 7.1
Tandem pore domain	K2P 1 2 3 4 5 6 7 9 10 12 13 15 16 17 18
Voltage-gated	K_vα1-6 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 2.1 2.2 3.1 3.2 3.3 3.4 4.1 4.2 4.3 5.1 6.1 6.2 6.3 6.4 K_vα7-12 7.1 7.2 7.3 7.4 7.5 8.1 8.2 9.1 9.2 9.3 10.1 10.2 11.1/hERG 11.2 11.3 12.1 12.2 12.3 K_vβ 1 2 3 KCNIP 1 2 3 4 minK/ISK minK/ISK-like MiRP 1 2 3 Shaker (gene)

Miscellaneous

Cl⁻: Chloride channel	Calcium-activated chloride channels Anoctamin ANO1 Bestrophin 1 2 Chloride Channel Accessory 1 2 3 4 CFTR CLCN 1 2 3 4 5 6 7 KA KB CLIC 1 2 3 4 5 6 L1 CLNS 1A 1B
H⁺: Proton channel	HVCN1
M⁺: CNG cation channel	α 1 2 3 4 β 1 2 3 HCN FC 1 2 3 4
M⁺: TRP cation channel	TRPA (1) TRPC 1 2 3 4 4AP 5 6 7 TRPM 1 2 3 4 5 6 7 8 TRPML 1 2 3 TRPN TRPP 1 2 TRPV 1 2 3 4 5 6
H₂O (+ solutes): Porin	Aquaporin 0 1 2 3 4 5 6 7 8 9 Voltage-dependent anion channel 1 2 3 General bacterial porin family
Cytoplasm: Gap junction	Connexin A GJA1 GJA3 GJA4 GJA5 GJA8 GJA9 GJA10 B GJB1 GJB2 GJB3 GJB4 GJB5 GJB6 GJB7 C GJC1 GJC2 GJC3 D GJD2 GJD3 GJD4 Innexin