Protein-coding gene in the species Homo sapiens
KCNU1 |
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Available structures |
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PDB | Ortholog search: PDBe RCSB |
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Identifiers |
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Aliases | KCNU1, KCNMC1, KCa5, KCa5.1, Kcnma3, Slo3, potassium calcium-activated channel subfamily U member 1 |
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External IDs | OMIM: 615215 MGI: 1202300 HomoloGene: 7392 GeneCards: KCNU1 |
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Gene location (Mouse) |
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| Chr. | Chromosome 8 (mouse)[1] |
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| Band | 8|8 A2 | Start | 26,339,651 bp[1] |
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End | 26,427,967 bp[1] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - sperm
- bone marrow cells
- caput epididymis
- substantia nigra
- monocyte
- mammary gland
- breast
- subcutaneous adipose tissue
- male reproductive gland
- prostate
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| Top expressed in | - spermatid
- seminiferous tubule
- spermatocyte
- facial motor nucleus
- islet of Langerhans
- morula
- anterior horn of spinal cord
- superior frontal gyrus
- blastocyst
- neural tube
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| More reference expression data |
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BioGPS | |
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Gene ontology |
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Molecular function | - voltage-gated potassium channel activity
- large conductance calcium-activated potassium channel activity
- ion channel activity
- potassium channel activity
- voltage-gated ion channel activity
- calcium-activated potassium channel activity
- outward rectifier potassium channel activity
| Cellular component | - integral component of membrane
- voltage-gated potassium channel complex
- plasma membrane
- membrane
| Biological process | - potassium ion transport
- regulation of ion transmembrane transport
- ion transport
- transmembrane transport
- potassium ion transmembrane transport
- sperm-egg recognition
- reproductive process
- regulation of membrane potential
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | | |
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RefSeq (protein) | | |
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Location (UCSC) | n/a | Chr 8: 26.34 – 26.43 Mb |
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PubMed search | [2] | [3] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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Potassium channel, subfamily U, member 1, also known as KCNU1, is a gene encoding the KCa5.1 protein.[4]
Although this channel is structurally related to the calcium-activated potassium channels, it cannot be classified as such since it is activated by high intracellular pH and relatively insensitive to changes in calcium concentrations.[5][6][7]
References
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031576 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Schreiber M, Wei A, Yuan A, Gaut J, Saito M, Salkoff L (February 1998). "Slo3, a novel pH-sensitive K+ channel from mammalian spermatocytes". J. Biol. Chem. 273 (6): 3509–16. doi:10.1074/jbc.273.6.3509. PMID 9452476.
- ^ Wei AD, Gutman GA, Aldrich R, Chandy KG, Grissmer S, Wulff H (2005). "International Union of Pharmacology. LII. Nomenclature and molecular relationships of calcium-activated potassium channels". Pharmacol Rev. 57 (4): 463–72. doi:10.1124/pr.57.4.9. PMID 16382103. S2CID 8290401.
- ^ Zhang X, Zeng X, Xia XM, Lingle CJ (September 2006). "pH-regulated Slo3 K+ channels: properties of unitary currents". J. Gen. Physiol. 128 (3): 301–15. doi:10.1085/jgp.200609551. PMC 2151565. PMID 16940554.
- ^ Zhang X, Zeng X, Lingle CJ (September 2006). "Slo3 K+ channels: voltage and pH dependence of macroscopic currents". J. Gen. Physiol. 128 (3): 317–36. doi:10.1085/jgp.200609552. PMC 2151566. PMID 16940555.
Celia M. Santi, Alice Butler, Julia Kuhn, Aguan Wei, Lawrence Salkoff. Bovine and mouse SLO3 K+ channels: Evolutionary divergence points to a RCK1 region of critical function. J Biol Chem.284: 21589-98 (2009).
External links
- Overview of all the structural information available in the PDB for UniProt: A8MYU2 (Potassium channel subfamily U member 1) at the PDBe-KB.
Further reading
- Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
- Schreiber M, Wei A, Yuan A, et al. (1998). "Slo3, a novel pH-sensitive K+ channel from mammalian spermatocytes". J. Biol. Chem. 273 (6): 3509–16. doi:10.1074/jbc.273.6.3509. PMID 9452476.
- Nusbaum C, Mikkelsen TS, Zody MC, et al. (2006). "DNA sequence and analysis of human chromosome 8". Nature. 439 (7074): 331–5. Bibcode:2006Natur.439..331N. doi:10.1038/nature04406. PMID 16421571.
- Wei AD, Gutman GA, Aldrich R, et al. (2005). "International Union of Pharmacology. LII. Nomenclature and molecular relationships of calcium-activated potassium channels". Pharmacol. Rev. 57 (4): 463–72. doi:10.1124/pr.57.4.9. PMID 16382103. S2CID 8290401.
Celia M. Santi, Alice Butler, Julia Kuhn, Aguan Wei, Lawrence Salkoff. Bovine and mouse SLO3 K+ channels: Evolutionary divergence points to a RCK1 region of critical function. J Biol Chem.284: 21589-98 (2009).
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