KDM4C

Protein-coding gene in the species Homo sapiens

KDM4C

Available structures

PDB

Ortholog search: PDBe RCSB

List of PDB id codes
2XDP, 2XML, 4XDO, 4XDP, 5FJK, 5FJH

Identifiers

Aliases

KDM4C, GASC1, JHDM3C, JMJD2C, TDRD14C, bA146B14.1, lysine demethylase 4C

External IDs

OMIM: 605469; MGI: 1924054; HomoloGene: 41004; GeneCards: KDM4C; OMA:KDM4C - orthologs

Gene location (Human)

Chr.	Chromosome 9 (human)^[1]

Band	9p24.1	Start	6,720,863 bp^[1]
Band	9p24.1	End	7,175,648 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 4 (mouse)^[2]

Band	4\|4 C3	Start	74,160,734 bp^[2]
Band	4\|4 C3	End	74,324,097 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

right hemisphere of cerebellum

epithelium of colon

bone marrow cells

tonsil

Achilles tendon

sural nerve

corpus callosum

body of pancreas

monocyte

granulocyte

Top expressed in

saccule

neural layer of retina

otic vesicle

otic placode

lacrimal gland

retinal pigment epithelium

granulocyte

interventricular septum

pineal gland

superior cervical ganglion

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	oxidoreductase activity histone H3-methyl-lysine-9 demethylase activity dioxygenase activity metal ion binding chromatin binding enzyme binding histone demethylase activity androgen receptor binding zinc ion binding histone H3-methyl-lysine-36 demethylase activity DNA-binding transcription repressor activity, RNA polymerase II-specific methylated histone binding
Cellular component	nucleus nucleoplasm pericentric heterochromatin histone methyltransferase complex
Biological process	regulation of transcription by RNA polymerase II regulation of transcription, DNA-templated transcription, DNA-templated positive regulation of cell population proliferation blastocyst formation regulation of gene expression positive regulation of gene expression histone H3-K9 demethylation positive regulation of neuron differentiation negative regulation of histone H3-K9 trimethylation regulation of stem cell population maintenance regulation of stem cell differentiation histone H3-K36 demethylation chromatin organization negative regulation of transcription by RNA polymerase II chromatin remodeling stem cell population maintenance
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


23081


76804

Ensembl


ENSG00000107077


ENSMUSG00000028397

UniProt


Q9H3R0


Q8VCD7

RefSeq (mRNA)

NM_001146694 NM_001146695 NM_001146696 NM_001304339 NM_001304340
NM_001304341 NM_015061 NM_001353997 NM_001353998 NM_001353999 NM_001354000 NM_001354001


NM_001172095 NM_144787 NM_001356561

RefSeq (protein)

NP_001140167 NP_001140168 NP_001291268 NP_001291269 NP_001291270
NP_055876 NP_001340926 NP_001340927 NP_001340928 NP_001340929 NP_001340930


NP_001165566 NP_659036 NP_001343490

Location (UCSC)

Chr 9: 6.72 – 7.18 Mb

Chr 4: 74.16 – 74.32 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Lysine-specific demethylase 4C is an enzyme that in humans is encoded by the KDM4C gene.^[5]^[6]^[7]

Function

This gene is a member of the Jumonji domain 2 (JMJD2) family and encodes a protein with one JmjC domain, one JmjN domain, two PHD-type zinc fingers, and two Tudor domains. This nuclear protein belongs to the alpha-ketoglutarate-dependent hydroxylase superfamily. It functions as a trimethylation-specific demethylase, converting specific trimethylated histone residues to the dimethylated form. Chromosomal aberrations and increased transcriptional expression of this gene are associated with esophageal squamous cell carcinoma.^[7] A expressional decrease of KDM4C was found during cardiac differentation of murine embryonic stem cells.^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000107077 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028397 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Oct 1998). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 5 (5): 277–86. doi:10.1093/dnares/5.5.277. PMID 9872452.
^ Katoh M, Katoh M (Jun 2004). "Identification and characterization of JMJD2 family genes in silico". International Journal of Oncology. 24 (6): 1623–8. doi:10.3892/ijo.25.3.759. PMID 15138608.
^ ^a ^b "Entrez Gene: JMJD2C jumonji domain containing 2C".
^ Boeckel, Jes-Niels; Derlet, Anja; Glaser, Simone F.; Luczak, Annika; Lucas, Tina; Heumüller, Andreas W.; Krüger, Marcus; Zehendner, Christoph M.; Kaluza, David (July 2016). "JMJD8 Regulates Angiogenic Sprouting and Cellular Metabolism by Interacting With Pyruvate Kinase M2 in Endothelial Cells". Arteriosclerosis, Thrombosis, and Vascular Biology. 36 (7): 1425–1433. doi:10.1161/ATVBAHA.116.307695. ISSN 1524-4636. PMID 27199445.

Yang ZQ, Imoto I, Fukuda Y, Pimkhaokham A, Shimada Y, Imamura M, Sugano S, Nakamura Y, Inazawa J (Sep 2000). "Identification of a novel gene, GASC1, within an amplicon at 9p23-24 frequently detected in esophageal cancer cell lines". Cancer Research. 60 (17): 4735–9. PMID 10987278.
Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (Jan 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Whetstine JR, Nottke A, Lan F, Huarte M, Smolikov S, Chen Z, Spooner E, Li E, Zhang G, Colaiacovo M, Shi Y (May 2006). "Reversal of histone lysine trimethylation by the JMJD2 family of histone demethylases". Cell. 125 (3): 467–81. doi:10.1016/j.cell.2006.03.028. PMID 16603238. S2CID 14461740.
Cloos PA, Christensen J, Agger K, Maiolica A, Rappsilber J, Antal T, Hansen KH, Helin K (Jul 2006). "The putative oncogene GASC1 demethylates tri- and dimethylated lysine 9 on histone H3". Nature. 442 (7100): 307–11. Bibcode:2006Natur.442..307C. doi:10.1038/nature04837. PMID 16732293. S2CID 2874903.
Wissmann M, Yin N, Müller JM, Greschik H, Fodor BD, Jenuwein T, Vogler C, Schneider R, Günther T, Buettner R, Metzger E, Schüle R (Mar 2007). "Cooperative demethylation by JMJD2C and LSD1 promotes androgen receptor-dependent gene expression". Nature Cell Biology. 9 (3): 347–53. doi:10.1038/ncb1546. PMID 17277772. S2CID 26006234.
Katoh Y, Katoh M (Aug 2007). "Comparative integromics on JMJD2A, JMJD2B and JMJD2C: preferential expression of JMJD2C in undifferentiated ES cells". International Journal of Molecular Medicine. 20 (2): 269–73. doi:10.3892/ijmm.20.2.269. PMID 17611647.
Zhao E, Ding J, Xia Y, Liu M, Ye B, Choi JH, Yan C, Dong Z, Huang S, Zha Y, Yang L, Cui H, Ding HF (2016). "KDM4C and ATF4 Cooperate in Transcriptional Control of Amino Acid Metabolism". Cell Reports. 14 (3): 506–519. doi:10.1016/j.celrep.2015.12.053. PMC 4731315. PMID 26774480.

Oxidoreductases: dioxygenases, including steroid hydroxylases (EC 1.14)

1.14.11: 2-oxoglutarate

1.14.13: NADH or NADPH

1.14.14: reduced flavin or flavoprotein

1.14.15: reduced iron–sulfur protein

1.14.16: reduced pteridine (BH4 dependent)

1.14.17: reduced ascorbate

Dopamine beta-hydroxylase

1.14.18-19: other

1.14.99 - miscellaneous

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)