KIAA1949

Protein-coding gene in the species Homo sapiens
PPP1R18
Identifiers
AliasesPPP1R18, HKMT1098, KIAA1949, protein phosphatase 1 regulatory subunit 18
External IDsOMIM: 610990; MGI: 1923698; HomoloGene: 19512; GeneCards: PPP1R18; OMA:PPP1R18 - orthologs
Gene location (Human)
Chromosome 6 (human)
Chr.Chromosome 6 (human)[1]
Chromosome 6 (human)
Genomic location for PPP1R18
Genomic location for PPP1R18
Band6p21.33Start30,676,389 bp[1]
End30,687,895 bp[1]
Gene location (Mouse)
Chromosome 17 (mouse)
Chr.Chromosome 17 (mouse)[2]
Chromosome 17 (mouse)
Genomic location for PPP1R18
Genomic location for PPP1R18
Band17|17 B1Start36,176,485 bp[2]
End36,186,488 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • blood

  • lymph node

  • spleen

  • monocyte

  • appendix

  • right coronary artery

  • ascending aorta

  • bone marrow

  • gallbladder

  • bone marrow cells
Top expressed in
  • thymus

  • blood

  • spleen

  • subcutaneous adipose tissue

  • external carotid artery

  • calvaria

  • internal carotid artery

  • entorhinal cortex

  • ascending aorta

  • white adipose tissue
More reference expression data
BioGPS
n/a
Orthologs
SpeciesHumanMouse
Entrez

170954

76448

Ensembl
ENSG00000229998
ENSG00000230341
ENSG00000225060
ENSG00000236428
ENSG00000146112

ENSG00000206485
ENSG00000231247
ENSG00000234000

ENSMUSG00000034595

UniProt

Q6NYC8

Q8BQ30

RefSeq (mRNA)

NM_001134870
NM_133471

NM_001146710
NM_001146711
NM_175242
NM_001378889

RefSeq (protein)

NP_001128342
NP_597728

NP_001140182
NP_001140183
NP_780451
NP_001365818

Location (UCSC)Chr 6: 30.68 – 30.69 MbChr 17: 36.18 – 36.19 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Phostensin is a protein that in humans is encoded by the KIAA1949 gene.[5][6]

References

  1. ^ a b c ENSG00000230341, ENSG00000225060, ENSG00000236428, ENSG00000146112, ENSG00000206485, ENSG00000231247, ENSG00000234000 GRCh38: Ensembl release 89: ENSG00000229998, ENSG00000230341, ENSG00000225060, ENSG00000236428, ENSG00000146112, ENSG00000206485, ENSG00000231247, ENSG00000234000 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000034595 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Nagase T, Kikuno R, Ohara O (Feb 2002). "Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins". DNA Res. 8 (6): 319–27. doi:10.1093/dnares/8.6.319. PMID 11853319.
  6. ^ "Entrez Gene: KIAA1949 KIAA1949".

Further reading

  • Kao SC, Chen CY, Wang SL, et al. (2007). "Identification of phostensin, a PP1 F-actin cytoskeleton targeting subunit". Biochem. Biophys. Res. Commun. 356 (3): 594–8. doi:10.1016/j.bbrc.2007.03.026. PMID 17374523.
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
  • Yamada S, Ohira M, Horie H, et al. (2004). "Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas". Oncogene. 23 (35): 5901–11. doi:10.1038/sj.onc.1207782. PMID 15221005. S2CID 3114318.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.


Stub icon

This article on a gene on human chromosome 6 is a stub. You can help Wikipedia by expanding it.

  • v
  • t
  • e