KIR3DL2

Protein-coding gene in the species Homo sapiens

KIR3DL2

Identifiers

Aliases

KIR3DL2, CD158K, NKAT-4, NKAT4, NKAT4B, p140, 3DL2, KIR-3DL2, killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 2

External IDs

OMIM: 604947 HomoloGene: 129622 GeneCards: KIR3DL2

Gene location (Human)

Chr.	Chromosome 19 (human)^[1]

Band	19q13.42	Start	54,850,443 bp^[1]
Band	19q13.42	End	54,867,207 bp^[1]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

blood

spleen

bone marrow

right lung

lymph node

gallbladder

upper lobe of left lung

appendix

thymus

salivary gland

n/a

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	protein binding MHC class Ib protein binding
Cellular component	integral component of membrane plasma membrane integral component of plasma membrane membrane
Biological process	cellular defense response regulation of immune response negative regulation of neuron death
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


3812


n/a

Ensembl

ENSG00000275629
ENSG00000275838
ENSG00000277709
ENSG00000273735
ENSG00000284192

ENSG00000276004
ENSG00000278361
ENSG00000284046
ENSG00000278442
ENSG00000275416
ENSG00000275626
ENSG00000284295
ENSG00000278707
ENSG00000278758
ENSG00000278656
ENSG00000278850
ENSG00000284213
ENSG00000276424
ENSG00000284528
ENSG00000277982
ENSG00000274722
ENSG00000278726
ENSG00000275511
ENSG00000275083
ENSG00000273911
ENSG00000283975
ENSG00000276357
ENSG00000278809
ENSG00000277181
ENSG00000284384
ENSG00000283951
ENSG00000278403
ENSG00000275262
ENSG00000278710
ENSG00000275566
ENSG00000284063
ENSG00000276882
ENSG00000240403
ENSG00000276739
ENSG00000284466
ENSG00000278474
ENSG00000284381
ENSG00000288389


n/a

UniProt


P43630 Q8NHI6


n/a

RefSeq (mRNA)


NM_001242867 NM_006737


n/a

RefSeq (protein)


NP_001229796 NP_006728 NP_001229796.1


n/a

Location (UCSC)

Chr 19: 54.85 – 54.87 Mb

n/a

PubMed search

^[2]

n/a

Wikidata

View/Edit Human

Killer cell immunoglobulin-like receptor 3DL2 is a protein that in humans is encoded by the KIR3DL2 gene.^[3]^[4]^[5]

Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. This gene is one of the "framework" loci that is present on all haplotypes.^[5]

References

^ ^a ^b ^c ENSG00000275838, ENSG00000277709, ENSG00000273735, ENSG00000284192, ENSG00000276004, ENSG00000278361, ENSG00000284046, ENSG00000278442, ENSG00000275416, ENSG00000275626, ENSG00000284295, ENSG00000278707, ENSG00000278758, ENSG00000278656, ENSG00000278850, ENSG00000284213, ENSG00000276424, ENSG00000284528, ENSG00000277982, ENSG00000274722, ENSG00000278726, ENSG00000275511, ENSG00000275083, ENSG00000273911, ENSG00000283975, ENSG00000276357, ENSG00000278809, ENSG00000277181, ENSG00000284384, ENSG00000283951, ENSG00000278403, ENSG00000275262, ENSG00000278710, ENSG00000275566, ENSG00000284063, ENSG00000276882, ENSG00000240403, ENSG00000276739, ENSG00000284466, ENSG00000278474, ENSG00000284381, ENSG00000288389 GRCh38: Ensembl release 89: ENSG00000275629, ENSG00000275838, ENSG00000277709, ENSG00000273735, ENSG00000284192, ENSG00000276004, ENSG00000278361, ENSG00000284046, ENSG00000278442, ENSG00000275416, ENSG00000275626, ENSG00000284295, ENSG00000278707, ENSG00000278758, ENSG00000278656, ENSG00000278850, ENSG00000284213, ENSG00000276424, ENSG00000284528, ENSG00000277982, ENSG00000274722, ENSG00000278726, ENSG00000275511, ENSG00000275083, ENSG00000273911, ENSG00000283975, ENSG00000276357, ENSG00000278809, ENSG00000277181, ENSG00000284384, ENSG00000283951, ENSG00000278403, ENSG00000275262, ENSG00000278710, ENSG00000275566, ENSG00000284063, ENSG00000276882, ENSG00000240403, ENSG00000276739, ENSG00000284466, ENSG00000278474, ENSG00000284381, ENSG00000288389 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Colonna M, Samaridis J (May 1995). "Cloning of immunoglobulin-superfamily members associated with HLA-C and HLA-B recognition by human natural killer cells". Science. 268 (5209): 405–8. Bibcode:1995Sci...268..405C. doi:10.1126/science.7716543. PMID 7716543.
^ Dohring C, Samaridis J, Colonna M (Aug 1996). "Alternatively spliced forms of human killer inhibitory receptors". Immunogenetics. 44 (3): 227–30. doi:10.1007/BF02602590. PMID 8662091. S2CID 38478576.
^ ^a ^b "Entrez Gene: KIR3DL2 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 2".

Wagtmann N, Biassoni R, Cantoni C, et al. (1995). "Molecular clones of the p58 NK cell receptor reveal immunoglobulin-related molecules with diversity in both the extra- and intracellular domains". Immunity. 2 (5): 439–49. doi:10.1016/1074-7613(95)90025-X. PMID 7749980.
Döhring C, Scheidegger D, Samaridis J, et al. (1996). "A human killer inhibitory receptor specific for HLA-A1,2". J. Immunol. 156 (9): 3098–101. doi:10.4049/jimmunol.156.9.3098. PMID 8617928.
Pende D, Biassoni R, Cantoni C, et al. (1996). "The natural killer cell receptor specific for HLA-A allotypes: a novel member of the p58/p70 family of inhibitory receptors that is characterized by three immunoglobulin-like domains and is expressed as a 140-kD disulphide-linked dimer". J. Exp. Med. 184 (2): 505–18. doi:10.1084/jem.184.2.505. PMC 2192700. PMID 8760804.
Wagtmann N, Rajagopalan S, Winter CC, et al. (1996). "Killer cell inhibitory receptors specific for HLA-C and HLA-B identified by direct binding and by functional transfer". Immunity. 3 (6): 801–9. doi:10.1016/1074-7613(95)90069-1. PMID 8777725.
Uhrberg M, Valiante NM, Shum BP, et al. (1998). "Human diversity in killer cell inhibitory receptor genes". Immunity. 7 (6): 753–63. doi:10.1016/S1074-7613(00)80394-5. PMID 9430221.
Kwon D, Chwae YJ, Choi IH, et al. (2000). "Diversity of the p70 killer cell inhibitory receptor (KIR3DL) family members in a single individual". Mol. Cells. 10 (1): 54–60. doi:10.1007/s10059-000-0054-0. PMID 10774747. S2CID 21075797.
Goodier MR, Londei M (2000). "Lipopolysaccharide stimulates the proliferation of human CD56+CD3- NK cells: a regulatory role of monocytes and IL-10". J. Immunol. 165 (1): 139–47. doi:10.4049/jimmunol.165.1.139. PMID 10861046.
Gardiner CM, Guethlein LA, Shilling HG, et al. (2001). "Different NK cell surface phenotypes defined by the DX9 antibody are due to KIR3DL1 gene polymorphism". J. Immunol. 166 (5): 2992–3001. doi:10.4049/jimmunol.166.5.2992. PMID 11207248.
Shilling HG, Guethlein LA, Cheng NW, et al. (2002). "Allelic polymorphism synergizes with variable gene content to individualize human KIR genotype". J. Immunol. 168 (5): 2307–15. doi:10.4049/jimmunol.168.5.2307. PMID 11859120.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Chan HW, Kurago ZB, Stewart CA, et al. (2003). "DNA methylation maintains allele-specific KIR gene expression in human natural killer cells". J. Exp. Med. 197 (2): 245–55. doi:10.1084/jem.20021127. PMC 2193817. PMID 12538663.
Becker S, Tonn T, Füssel T, et al. (2003). "Assessment of killer cell immunoglobulinlike receptor expression and corresponding HLA class I phenotypes demonstrates heterogenous KIR expression independent of anticipated HLA class I ligands". Hum. Immunol. 64 (2): 183–93. doi:10.1016/S0198-8859(02)00802-9. PMID 12559621.
Dorothée G, Echchakir H, Le Maux Chansac B, et al. (2003). "Functional and molecular characterization of a KIR3DL2/p140 expressing tumor-specific cytotoxic T lymphocyte clone infiltrating a human lung carcinoma". Oncogene. 22 (46): 7192–8. doi:10.1038/sj.onc.1206627. PMID 14562047. S2CID 23893345.
Artavanis-Tsakonas K, Eleme K, McQueen KL, et al. (2004). "Activation of a subset of human NK cells upon contact with Plasmodium falciparum-infected erythrocytes". J. Immunol. 171 (10): 5396–405. doi:10.4049/jimmunol.171.10.5396. PMID 14607943.
Meenagh A, Williams F, Sleator C, et al. (2005). "Investigation of killer cell immunoglobulin-like receptor gene diversity V. KIR3DL2". Tissue Antigens. 64 (3): 226–34. doi:10.1111/j.1399-0039.2004.00272.x. PMID 15304002.
Yan LX, Zhu FM, Jiang K, et al. (2006). "Investigation of killer cell immunoglobulin-like receptors gene KIR3DL2 diversity and confirmation of KIR3DL2*015 in a Chinese population". Tissue Antigens. 68 (3): 220–4. doi:10.1111/j.1399-0039.2006.00651.x. PMID 16948642.
Ortonne N, Bagot M, Bensussan A (2006). "[KIR3DL2: a new step for the management of patients with Sezary syndrome]" (PDF). Med Sci (Paris). 22 (8–9): 691–3. doi:10.1051/medsci/20062289691. PMID 16962036.
Gedil MA, Steiner NK, Hurley CK (2007). "KIR3DL2: diversity in a hematopoietic stem cell transplant population". Tissue Antigens. 70 (3): 228–32. doi:10.1111/j.1399-0039.2007.00880.x. PMID 17661911.