KIR3DL3

Protein-coding gene in the species Homo sapiens
KIR3DL3
Identifiers
AliasesKIR3DL3, CD158Z, KIR3DL7, KIR44, KIRC1, KIR2DS2, killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 3
External IDsOMIM: 610095 MGI: 3612791 HomoloGene: 77448 GeneCards: KIR3DL3
Gene location (Human)
Chromosome 19 (human)
Chr.Chromosome 19 (human)[1]
Chromosome 19 (human)
Genomic location for KIR3DL3
Genomic location for KIR3DL3
Band19q13.42Start54,724,442 bp[1]
End54,736,632 bp[1]
Gene location (Mouse)
X chromosome (mouse)
Chr.X chromosome (mouse)[2]
X chromosome (mouse)
Genomic location for KIR3DL3
Genomic location for KIR3DL3
BandX F1|X 58.45 cMStart135,348,856 bp[2]
End135,444,805 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • blood
Top expressed in
  • zone of skin

  • hypothalamus

  • spermatid

  • placenta
More reference expression data
BioGPS
n/a
Orthologs
SpeciesHumanMouse
Entrez

115653

245615

Ensembl
ENSG00000274394
ENSG00000283823
ENSG00000274511
ENSG00000276196
ENSG00000275433

ENSG00000276086
ENSG00000283875
ENSG00000274480
ENSG00000277392
ENSG00000274786
ENSG00000274724
ENSG00000276930
ENSG00000276572
ENSG00000284371
ENSG00000276084
ENSG00000284104
ENSG00000278729
ENSG00000277028
ENSG00000275062
ENSG00000274763
ENSG00000276433
ENSG00000274639
ENSG00000283966
ENSG00000284127
ENSG00000277552
ENSG00000278490
ENSG00000276806
ENSG00000242019
ENSG00000276328
ENSG00000276875
ENSG00000274556
ENSG00000283915
ENSG00000284086
ENSG00000278723
ENSG00000284480
ENSG00000273502
ENSG00000274254
ENSG00000275172
ENSG00000275513
ENSG00000277620
ENSG00000274696
ENSG00000277596

ENSMUSG00000057439

UniProt

Q8N743

Q673W2

RefSeq (mRNA)

NM_153443

NM_177748

RefSeq (protein)

NP_703144

NP_808416

Location (UCSC)Chr 19: 54.72 – 54.74 MbChr X: 135.35 – 135.44 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Killer cell immunoglobulin-like receptor 3DL3 is a protein that in humans is encoded by the KIR3DL3 gene.[5][6]

Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR2DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. This gene is one of the "framework" loci that is present on all haplotypes.[6]

References

  1. ^ a b c ENSG00000283823, ENSG00000274511, ENSG00000276196, ENSG00000275433, ENSG00000276086, ENSG00000283875, ENSG00000274480, ENSG00000277392, ENSG00000274786, ENSG00000274724, ENSG00000276930, ENSG00000276572, ENSG00000284371, ENSG00000276084, ENSG00000284104, ENSG00000278729, ENSG00000277028, ENSG00000275062, ENSG00000274763, ENSG00000276433, ENSG00000274639, ENSG00000283966, ENSG00000284127, ENSG00000277552, ENSG00000278490, ENSG00000276806, ENSG00000242019, ENSG00000276328, ENSG00000276875, ENSG00000274556, ENSG00000283915, ENSG00000284086, ENSG00000278723, ENSG00000284480, ENSG00000273502, ENSG00000274254, ENSG00000275172, ENSG00000275513, ENSG00000277620, ENSG00000274696, ENSG00000277596 GRCh38: Ensembl release 89: ENSG00000274394, ENSG00000283823, ENSG00000274511, ENSG00000276196, ENSG00000275433, ENSG00000276086, ENSG00000283875, ENSG00000274480, ENSG00000277392, ENSG00000274786, ENSG00000274724, ENSG00000276930, ENSG00000276572, ENSG00000284371, ENSG00000276084, ENSG00000284104, ENSG00000278729, ENSG00000277028, ENSG00000275062, ENSG00000274763, ENSG00000276433, ENSG00000274639, ENSG00000283966, ENSG00000284127, ENSG00000277552, ENSG00000278490, ENSG00000276806, ENSG00000242019, ENSG00000276328, ENSG00000276875, ENSG00000274556, ENSG00000283915, ENSG00000284086, ENSG00000278723, ENSG00000284480, ENSG00000273502, ENSG00000274254, ENSG00000275172, ENSG00000275513, ENSG00000277620, ENSG00000274696, ENSG00000277596 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000057439 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Long EO, Barber DF, Burshtyn DN, Faure M, Peterson M, Rajagopalan S, Renard V, Sandusky M, Stebbins CC, Wagtmann N, Watzl C (Aug 2001). "Inhibition of natural killer cell activation signals by killer cell immunoglobulin-like receptors (CD158)". Immunol Rev. 181: 223–233. doi:10.1034/j.1600-065X.2001.1810119.x. PMID 11513144. S2CID 13312691.
  6. ^ a b "Entrez Gene: KIR3DL3 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 3".

Further reading

  • Dou LP, Zheng DH, Wang C, Liu JH, Sun JF, Jin HJ, Gao CJ, Yu L, Da WM (2008). "The diversity of KIR gene in Chinese Northern Han population and the impact of donor KIR and patient HLA genotypes on outcome following HLA-identical sibling allogeneic hematopoietic stem cell transplantation for hematological malignancy in Chinese people". Int. J. Hematol. 87 (4): 422–433. doi:10.1007/s12185-008-0058-7. PMID 18347914. S2CID 32702080.
  • Pavlova Y, Kolesar L, Striz I, Jabor A, Slavcev A (2008). "Distribution of KIR genes in the Czech population". International Journal of Immunogenetics. 35 (1): 57–61. doi:10.1111/j.1744-313X.2007.00737.x. PMID 18186800. S2CID 25268211.
  • Zhi-ming L, Yu-lian J, Zhao-lei F, Chun-Xiao W, Zhen-Fang D, Bing-Chang Z, Yue-Ran Z (2008). "Polymorphisms of killer cell immunoglobulin-like receptor gene: possible association with susceptibility to or clearance of hepatitis B virus infection in Chinese Han population". Croat. Med. J. 48 (6): 800–807. doi:10.3325/cmj.2007.6.800. PMC 2213808. PMID 18074414.
  • Middleton D, Meenagh A, Sleator C, Gourraud PA, Ayna T, Tozkir H, Köse AA, Azizleri G, Diler AS (2007). "No association of KIR genes with Behcet's disease". Tissue Antigens. 70 (5): 435–438. doi:10.1111/j.1399-0039.2007.00929.x. PMID 17868255.
  • Flores AC, Marcos CY, Paladino N, Capucchio M, Theiler G, Arruvito L, Pardo R, Habegger A, Williams F (2007). "KIR genes polymorphism in Argentinean Caucasoid and Amerindian populations". Tissue Antigens. 69 (6): 568–576. doi:10.1111/j.1399-0039.2007.00824.x. hdl:11336/115970. PMID 17498266.
  • Chen AM, Guo XM, Yan WY, Xie SM, Zhu N, Wang XD, Xu R, Liu QP (2007). "[Polymorphism of killer cell immunoglobulin-like receptor gene and its correlation with leukemia]". Zhongguo Shi Yan Xue Ye Xue Za Zhi. 15 (1): 35–8. PMID 17490516.
  • Jones DC, Hiby SE, Moffett A, Trowsdale J, Young NT (2006). "Nature of allelic sequence polymorphism at the KIR3DL3 locus". Immunogenetics. 58 (8): 614–627. doi:10.1007/s00251-006-0130-5. PMID 16823588. S2CID 6120931.
  • Steiner NK, Hurley CK (2006). "KIR3DL3 allelic diversity: six new alleles exhibit both conservative and non-conservative substitutions". Tissue Antigens. 67 (4): 277–283. doi:10.1111/j.1399-0039.2006.00567.x. PMID 16634863.
  • Zhu FM, Jiang K, Lü QF, Zhang W, Zhang HQ, Fu QH, Yan LX (2005). "[Polymorphism of killer cell immunoglobulin-like receptors gene family in Zhejiang Han population]". Zhongguo Shi Yan Xue Ye Xue Za Zhi. 13 (6): 1109–12. PMID 16403292.
  • Trundley AE, Hiby SE, Chang C, Sharkey AM, Santourlidis S, Uhrberg M, Trowsdale J, Moffett A (2006). "Molecular characterization of KIR3DL3". Immunogenetics. 57 (12): 904–916. doi:10.1007/s00251-005-0060-7. PMID 16391939. S2CID 25125407.
  • Jiang K, Zhu FM, Lv QF, Yan LX (2005). "Distribution of killer cell immunoglobulin-like receptor genes in the Chinese Han population". Tissue Antigens. 65 (6): 556–563. doi:10.1111/j.1399-0039.2005.00412.x. PMID 15896204.
  • Trompeter HI, Gómez-Lozano N, Santourlidis S, Eisermann B, Wernet P, Vilches C, Uhrberg M (2005). "Three structurally and functionally divergent kinds of promoters regulate expression of clonally distributed killer cell Ig-like receptors (KIR), of KIR2DL4, and of KIR3DL3". J. Immunol. 174 (7): 4135–43. doi:10.4049/jimmunol.174.7.4135. PMID 15778373.
  • Arnheim L, Dillner J, Sanjeevi CB (2005). "A population-based cohort study of KIR genes and genotypes in relation to cervical intraepithelial neoplasia". Tissue Antigens. 65 (3): 252–259. doi:10.1111/j.1399-0039.2005.00359.x. PMID 15730517.
  • Norman PJ, Carrington CV, Byng M, Maxwell LD, Curran MD, Stephens HA, Chandanayingyong D, Verity DH, Hameed K (2002). "Natural killer cell immunoglobulin-like receptor (KIR) locus profiles in African and South Asian populations". Genes Immun. 3 (2): 86–95. doi:10.1038/sj.gene.6363836. PMID 11960306. S2CID 25892926.
  • Torkar M, Norgate Z, Colonna M, Trowsdale J, Wilson MJ (1999). "Isotypic variation of novel immunoglobulin-like transcript/killer cell inhibitory receptor loci in the leukocyte receptor complex". Eur. J. Immunol. 28 (12): 3959–3967. doi:10.1002/(SICI)1521-4141(199812)28:12<3959::AID-IMMU3959>3.0.CO;2-2. PMID 9862332.