KLF12

KLF12
Identifiers
Aliases	KLF12, AP-2rep, AP2REP, HSPC122, Kruppel-like factor 12, Kruppel like factor 12
External IDs	OMIM: 607531 MGI: 1333796 HomoloGene: 21417 GeneCards: KLF12
Gene location (Human) Chr. Chromosome 13 (human)[1] Band 13q22.1 Start 73,686,089 bp[1] End 74,133,929 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14 E2.2-E2.3|14 50.9 cM Start 99,870,632 bp[2] End 100,284,679 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in corpus epididymis superficial temporal artery retinal pigment epithelium caput epididymis Brodmann area 23 biceps brachii synovial joint internal globus pallidus ganglionic eminence saphenous vein Top expressed in retinal pigment epithelium dorsal tegmental nucleus habenula lateral geniculate nucleus medial geniculate nucleus pontine nuclei medial ganglionic eminence ventral tegmental area median eminence medial dorsal nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding protein binding transcription corepressor activity metal ion binding nucleic acid binding DNA-binding transcription factor activity DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II transcription regulatory region sequence-specific DNA binding DNA-binding transcription repressor activity, RNA polymerase II-specific Cellular component nucleus nucleoplasm cytosol Biological process regulation of transcription by RNA polymerase II regulation of transcription, DNA-templated transcription, DNA-templated negative regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 11278 16597 Ensembl ENSG00000118922 ENSMUSG00000072294 UniProt Q9Y4X4 O35738 RefSeq (mRNA) NM_007249 NM_016285 NM_010636 RefSeq (protein) NP_009180 NP_034766 Location (UCSC) Chr 13: 73.69 – 74.13 Mb Chr 14: 99.87 – 100.28 Mb PubMed search [3] [4]
Wikidata
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Krueppel-like factor 12 is a protein that in humans is encoded by the KLF12 gene.^[5][6]

Activator protein-2 alpha (AP-2 alpha) is a developmentally-regulated transcription factor and important regulator of gene expression during vertebrate development and carcinogenesis. The protein encoded by this gene is a member of the Kruppel-like zinc finger protein family and can repress expression of the AP-2 alpha gene by binding to a specific site in the AP-2 alpha gene promoter. Repression by the encoded protein requires binding with a corepressor, CtBP1. Two transcript variants encoding different isoforms have been found for this gene.^[6]

See also

• Kruppel-like factors

References

Further reading

External links

• KLF12+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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