KLF17

Protein-coding gene in the species Homo sapiens
KLF17
Identifiers
AliasesKLF17, ZNF393, Zfp393, Kruppel-like factor 17, Kruppel like factor 17, ZLF393
External IDsOMIM: 609602 MGI: 2181068 HomoloGene: 12621 GeneCards: KLF17
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for KLF17
Genomic location for KLF17
Band1p34.1Start44,118,821 bp[1]
End44,135,140 bp[1]
Gene location (Mouse)
Chromosome 4 (mouse)
Chr.Chromosome 4 (mouse)[2]
Chromosome 4 (mouse)
Genomic location for KLF17
Genomic location for KLF17
Band4 D1|4 53.46 cMStart117,615,033 bp[2]
End117,622,845 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • smooth muscle tissue

  • sperm

  • stromal cell of endometrium

  • right lung

  • left adrenal gland

  • right adrenal gland

  • urinary bladder

  • myometrium

  • gallbladder

  • appendix
Top expressed in
  • secondary oocyte

  • spermatid

  • urethra

  • male urethra

  • morula

  • seminiferous tubule

  • detrusor urinae muscle

  • spermatocyte

  • right ventricle

  • triceps brachii muscle
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • DNA binding
  • protein binding
  • metal ion binding
  • nucleic acid binding
  • DNA-binding transcription factor activity
  • DNA-binding transcription factor activity, RNA polymerase II-specific
  • DNA-binding transcription repressor activity, RNA polymerase II-specific
Cellular component
  • nucleus
Biological process
  • regulation of transcription, DNA-templated
  • transcription, DNA-templated
  • regulation of transcription by RNA polymerase II
  • negative regulation of transcription by RNA polymerase II
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

128209

75753

Ensembl

ENSG00000171872

ENSMUSG00000048626

UniProt

Q5JT82

Q8CFA7

RefSeq (mRNA)

NM_173484

NM_029416

RefSeq (protein)

NP_775755

NP_083692

Location (UCSC)Chr 1: 44.12 – 44.14 MbChr 4: 117.62 – 117.62 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Krueppel-like factor 17 is a protein that in humans is encoded by the KLF17 gene.[5][6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000171872 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000048626 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ van Vliet J, Crofts LA, Quinlan KG, Czolij R, Perkins AC, Crossley M (Apr 2006). "Human KLF17 is a new member of the Sp/KLF family of transcription factors". Genomics. 87 (4): 474–82. doi:10.1016/j.ygeno.2005.12.011. PMID 16460907.
  6. ^ "Entrez Gene: KLF17 Kruppel-like factor 17".

Further reading

  • Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (Jan 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
  • Yan W, Burns KH, Ma L, Matzuk MM (Oct 2002). "Identification of Zfp393, a germ cell-specific gene encoding a novel zinc finger protein". Mechanisms of Development. 118 (1–2): 233–9. doi:10.1016/S0925-4773(02)00258-7. PMID 12351194. S2CID 16603729.

External links

  • v
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  • e
(1) Basic domains
(1.1) Basic leucine zipper (bZIP)
(1.2) Basic helix-loop-helix (bHLH)
Group A
Group B
Group C
bHLH-PAS
Group D
Group E
Group F
bHLH-COE
(1.3) bHLH-ZIP
(1.4) NF-1
(1.5) RF-X
(1.6) Basic helix-span-helix (bHSH)
(2) Zinc finger DNA-binding domains
(2.1) Nuclear receptor (Cys4)
subfamily 1
subfamily 2
subfamily 3
subfamily 4
subfamily 5
subfamily 6
subfamily 0
(2.2) Other Cys4
(2.3) Cys2His2
(2.4) Cys6
(2.5) Alternating composition
(2.6) WRKY
(3) Helix-turn-helix domains
(3.1) Homeodomain
Antennapedia
ANTP class
protoHOX
Hox-like
metaHOX
NK-like
other
(3.2) Paired box
(3.3) Fork head / winged helix
(3.4) Heat shock factors
(3.5) Tryptophan clusters
(3.6) TEA domain
  • transcriptional enhancer factor
(4) β-Scaffold factors with minor groove contacts
(4.1) Rel homology region
(4.2) STAT
(4.3) p53-like
(4.4) MADS box
(4.6) TATA-binding proteins
(4.7) High-mobility group
(4.9) Grainyhead
(4.10) Cold-shock domain
(4.11) Runt
(0) Other transcription factors
(0.2) HMGI(Y)
(0.3) Pocket domain
(0.5) AP-2/EREBP-related factors
(0.6) Miscellaneous
see also transcription factor/coregulator deficiencies


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