KLF7

Protein-coding gene in the species Homo sapiens
KLF7
Identifiers
AliasesKLF7, UKLF, Kruppel-like factor 7 (ubiquitous), Kruppel like factor 7
External IDsOMIM: 604865 MGI: 1935151 HomoloGene: 2751 GeneCards: KLF7
Gene location (Human)
Chromosome 2 (human)
Chr.Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for KLF7
Genomic location for KLF7
Band2q33.3Start207,074,137 bp[1]
End207,167,267 bp[1]
Gene location (Mouse)
Chromosome 1 (mouse)
Chr.Chromosome 1 (mouse)[2]
Chromosome 1 (mouse)
Genomic location for KLF7
Genomic location for KLF7
Band1|1 C2Start64,068,606 bp[2]
End64,161,441 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • saphenous vein

  • ganglionic eminence

  • Achilles tendon

  • spinal ganglia

  • bone marrow cells

  • sural nerve

  • hair follicle

  • lower lobe of lung

  • blood

  • monocyte
Top expressed in
  • trigeminal ganglion

  • spinal ganglia

  • supraoptic nucleus

  • aortic valve

  • ascending aorta

  • barrel cortex

  • saccule

  • motor neuron

  • superior cervical ganglion

  • otic placode
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • DNA-binding transcription factor activity
  • DNA binding
  • transcription coactivator activity
  • zinc ion binding
  • metal ion binding
  • nucleic acid binding
  • RNA polymerase II cis-regulatory region sequence-specific DNA binding
  • DNA-binding transcription activator activity, RNA polymerase II-specific
  • DNA-binding transcription factor activity, RNA polymerase II-specific
Cellular component
  • nucleus
Biological process
  • regulation of transcription by RNA polymerase II
  • positive regulation of transcription, DNA-templated
  • regulation of transcription, DNA-templated
  • axonogenesis
  • transcription, DNA-templated
  • dendrite morphogenesis
  • axon guidance
  • transcription by RNA polymerase II
  • positive regulation of transcription by RNA polymerase II
  • regulation of epidermal cell differentiation
  • regulation of insulin secretion
  • negative regulation of adipose tissue development
  • negative regulation of transcription by RNA polymerase II
  • glucose homeostasis
  • negative regulation of insulin secretion involved in cellular response to glucose stimulus
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

8609

93691

Ensembl

ENSG00000118263

ENSMUSG00000025959

UniProt

O75840

Q99JB0

RefSeq (mRNA)

NM_001270942
NM_001270943
NM_001270944
NM_003709

NM_033563

RefSeq (protein)

NP_001257871
NP_001257872
NP_001257873
NP_003700

NP_291041

Location (UCSC)Chr 2: 207.07 – 207.17 MbChr 1: 64.07 – 64.16 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Kruppel-like factor 7 (ubiquitous), also known as KLF7, is a protein which in humans is encoded by the KLF7 gene.[5][6]

This protein is a member of the Kruppel-like family of transcription factors.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000118263 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025959 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: KLF7 Kruppel-like factor 7 (ubiquitous)".
  6. ^ Matsumoto N, Laub F, Aldabe R, Zhang W, Ramirez F, Yoshida T, Terada M (October 1998). "Cloning the cDNA for a new human zinc finger protein defines a group of closely related Krüppel-like transcription factors". The Journal of Biological Chemistry. 273 (43): 28229–37. doi:10.1074/jbc.273.43.28229. PMID 9774444.
  7. ^ Bieker JJ (September 2001). "Krüppel-like factors: three fingers in many pies". The Journal of Biological Chemistry. 276 (37): 34355–8. doi:10.1074/jbc.R100043200. PMID 11443140.

Further reading

  • Cho SY, Park PJ, Shin HJ, et al. (2007). "(-)-Catechin suppresses expression of Kruppel-like factor 7 and increases expression and secretion of adiponectin protein in 3T3-L1 cells". Am. J. Physiol. Endocrinol. Metab. 292 (4): E1166–72. doi:10.1152/ajpendo.00436.2006. PMID 17164435.
  • Kawamura Y, Tanaka Y, Kawamori R, Maeda S (2006). "Overexpression of Kruppel-like factor 7 regulates adipocytokine gene expressions in human adipocytes and inhibits glucose-induced insulin secretion in pancreatic beta-cell line". Mol. Endocrinol. 20 (4): 844–56. doi:10.1210/me.2005-0138. PMID 16339272.
  • Kanazawa A, Kawamura Y, Sekine A, et al. (2005). "Single nucleotide polymorphisms in the gene encoding Krüppel-like factor 7 are associated with type 2 diabetes". Diabetologia. 48 (7): 1315–22. doi:10.1007/s00125-005-1797-0. PMID 15937668.
  • Smaldone S, Laub F, Else C, et al. (2004). "Identification of MoKA, a novel F-box protein that modulates Krüppel-like transcription factor 7 activity". Mol. Cell. Biol. 24 (3): 1058–69. doi:10.1128/MCB.24.3.1058-1069.2004. PMC 321422. PMID 14729953.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Suzuki S, Chuang LF, Doi RH, Chuang RY (2004). "Identification of opioid-regulated genes in human lymphocytic cells by differential display: upregulation of Krüppel-like factor 7 by morphine". Exp. Cell Res. 291 (2): 340–51. doi:10.1016/S0014-4827(03)00408-7. PMID 14644156.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Matsumoto N, Laub F, Aldabe R, et al. (1998). "Cloning the cDNA for a new human zinc finger protein defines a group of closely related Krüppel-like transcription factors". J. Biol. Chem. 273 (43): 28229–37. doi:10.1074/jbc.273.43.28229. PMID 9774444.

External links

  • v
  • t
  • e
(1) Basic domains
(1.1) Basic leucine zipper (bZIP)
(1.2) Basic helix-loop-helix (bHLH)
Group A
Group B
Group C
bHLH-PAS
Group D
Group E
Group F
bHLH-COE
(1.3) bHLH-ZIP
(1.4) NF-1
(1.5) RF-X
(1.6) Basic helix-span-helix (bHSH)
(2) Zinc finger DNA-binding domains
(2.1) Nuclear receptor (Cys4)
subfamily 1
subfamily 2
subfamily 3
subfamily 4
subfamily 5
subfamily 6
subfamily 0
(2.2) Other Cys4
(2.3) Cys2His2
(2.4) Cys6
(2.5) Alternating composition
(2.6) WRKY
(3) Helix-turn-helix domains
(3.1) Homeodomain
Antennapedia
ANTP class
protoHOX
Hox-like
metaHOX
NK-like
other
(3.2) Paired box
(3.3) Fork head / winged helix
(3.4) Heat shock factors
(3.5) Tryptophan clusters
(3.6) TEA domain
  • transcriptional enhancer factor
(4) β-Scaffold factors with minor groove contacts
(4.1) Rel homology region
(4.2) STAT
(4.3) p53-like
(4.4) MADS box
(4.6) TATA-binding proteins
(4.7) High-mobility group
(4.9) Grainyhead
(4.10) Cold-shock domain
(4.11) Runt
(0) Other transcription factors
(0.2) HMGI(Y)
(0.3) Pocket domain
(0.5) AP-2/EREBP-related factors
(0.6) Miscellaneous
see also transcription factor/coregulator deficiencies


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