Kobophenol A
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Names | |||
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Preferred IUPAC name (2S,2′R,3S,3′R)-3′-(3,5-Dihydroxyphenyl)-4-[(2S,3S,4R,5S)-4-(3,5-dihydroxyphenyl)-2,5-bis(4-hydroxyphenyl)oxolan-3-yl]-2,2′-bis(4-hydroxyphenyl)-2,2′,3,3′-tetrahydro[3,4′-bi-1-benzofuran]-6,6′-diol | |||
Other names kob A | |||
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3D model (JSmol) |
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CompTox Dashboard (EPA) |
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InChI
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Properties | |||
Chemical formula | C56H44O13 | ||
Molar mass | 924.94 g/mol | ||
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). N verify (what is YN ?) Infobox references |
Chemical compound
Kobophenol A is a stilbenoid. It is a tetramer of resveratrol. It can be isolated from Caragana chamlagu,[1] from Caragana sinica[2] and from Carex folliculata seeds.[3]
The molecule shows a 2,3,4,5-tetraaryltetrahydrofuran skeleton.[3]
It has been shown to inhibit acetylcholinesterase.[1]
Acid-catalyzed epimerization of kobophenol A to carasinol B can be performed in vitro.[4]
References
- ^ a b (+)-α-Viniferin, a Stilbene Trimer from Caragana chamlague, Inhibits Acetylcholinesterase. Sang Hyun Sung, So Young Kang, Ki Yong Lee, Mi Jung Park, Jeong Hun Kim, Jong Hee Park, Young Chul Kim, Jinwoong Kim and Young Choong Kim, Biological & Pharmaceutical Bulletin, Vol. 25, 2002 [permanent dead link]
- ^ Simultaneous determination of the contents of three stilbene oligomers in Caragana sinica collected in different seasons using an improved HPLC method. Shu Na; Zhou Hong; Hu Changqi, Biological & pharmaceutical bulletin, 2006, vol. 29, no4, pp. 608-612
- ^ a b Identification and bioactivities of resveratrol oligomers and flavonoids from Carex folliculata seeds. Li L, Henry GE and Seeram NP, J Agric Food Chem., 26 August 2009, volume 57, issue 16, pages 7282-7287, doi:10.1021/jf901716j
- ^ Acid-catalyzed Epimerization of Kobophenol A to Carasinol B. Kejun Cheng, Gaolin Liang and Changqi Hu, Molecules 2008, 13(4), 938-942
- v
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- e
(modulators)
(modulators)
CHTTooltip Choline transporter |
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VAChTTooltip Vesicular acetylcholine transporter |
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(modulators)
Inhibitors |
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Enhancers |
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- See also
- Receptor/signaling modulators
- Muscarinic acetylcholine receptor modulators
- Nicotinic acetylcholine receptor modulators