L-687,384
Chemical compound
- none
- 1'-benzylspiro[2,3-dihydro-1H-naphthalene-4,4'-piperidine]
- 95417-67-7
Y
- 125328
- 111534
N
- NVE9K68QA3
- ChEMBL303336
- DTXSID30241828
- Interactive image
- c3ccccc3CN2CCC1(CC2)CCCc4c1cccc4
InChI
- InChI=1S/C21H25N/c1-2-7-18(8-3-1)17-22-15-13-21(14-16-22)12-6-10-19-9-4-5-11-20(19)21/h1-5,7-9,11H,6,10,12-17H2N
- Key:MLDCBJPLHBPJET-UHFFFAOYSA-NN
N
Y (what is this?) (verify)L-687,384 is a sigma receptor agonist, selective for the σ1 subtype,[1] as well as an NMDA antagonist.[2]
References
- ^ Bergeron R, Debonnel G (February 1997). "Effects of low and high doses of selective sigma ligands: further evidence suggesting the existence of different subtypes of sigma receptors". Psychopharmacology. 129 (3): 215–24. doi:10.1007/s002130050183. PMID 9084059. S2CID 24537111.
- ^ McLarnon J, Sawyer D, Church J (June 1994). "The actions of L-687,384, a sigma receptor ligand, on NMDA-induced currents in cultured rat hippocampal pyramidal neurons". Neuroscience Letters. 174 (2): 181–4. doi:10.1016/0304-3940(94)90016-7. PMID 7526288. S2CID 10876486.
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See also: Receptor/signaling modulators • Ionotropic glutamate receptor modulators • Glutamate metabolism/transport modulators | |||||||||
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