Protein-coding gene in the species Homo sapiens
LANCL1 |
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Available structures |
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PDB | Ortholog search: PDBe RCSB |
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List of PDB id codes |
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3E6U, 3E73 |
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Identifiers |
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Aliases | LANCL1, GPR69A, p40, LanC like 1 |
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External IDs | OMIM: 604155 MGI: 1336997 HomoloGene: 4417 GeneCards: LANCL1 |
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Gene location (Human) |
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| Chr. | Chromosome 2 (human)[1] |
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| Band | 2q34 | Start | 210,431,249 bp[1] |
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End | 210,477,652 bp[1] |
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Gene location (Mouse) |
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| Chr. | Chromosome 1 (mouse)[2] |
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| Band | 1|1 C3 | Start | 67,039,676 bp[2] |
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End | 67,078,031 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - endothelial cell
- corpus callosum
- inferior ganglion of vagus nerve
- subthalamic nucleus
- inferior olivary nucleus
- Brodmann area 46
- postcentral gyrus
- external globus pallidus
- middle temporal gyrus
- Brodmann area 23
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| Top expressed in | - seminiferous tubule
- spermatid
- spermatocyte
- corneal stroma
- facial motor nucleus
- anterior horn of spinal cord
- barrel cortex
- cingulate gyrus
- olfactory tubercle
- amygdala
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| More reference expression data |
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BioGPS | |
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Gene ontology |
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Molecular function | - SH3 domain binding
- low-density lipoprotein particle receptor binding
- zinc ion binding
- protein binding
- G protein-coupled receptor activity
- metal ion binding
- glutathione binding
- catalytic activity
- glutathione transferase activity
- transferase activity
| Cellular component | - cytoplasm
- integral component of plasma membrane
- membrane
- plasma membrane
| Biological process | - G protein-coupled receptor signaling pathway
- regulation of neuron apoptotic process
- regulation of oxidative stress-induced neuron death
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | |
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NM_001136574 NM_001136575 NM_006055 |
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NM_001190984 NM_001190985 NM_021295 |
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RefSeq (protein) | |
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NP_001130046 NP_001130047 NP_006046 |
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NP_001177913 NP_001177914 NP_067270 |
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Location (UCSC) | Chr 2: 210.43 – 210.48 Mb | Chr 1: 67.04 – 67.08 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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LanC like 1 is a protein that in humans is encoded by the LANCL1 gene. [5]
Function
This gene encodes a loosely associated peripheral membrane protein related to the LanC family of bacterial membrane-associated proteins involved in the biosynthesis of antimicrobial peptides. This protein may play a role as a peptide-modifying enzyme component in eukaryotic cells. Previously considered a member of the G-protein-coupled receptor superfamily, this protein is now in the LanC family. Multiple alternatively spliced variants, encoding the same protein, have been identified.
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000115365 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026000 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: LanC like 1". Retrieved 2016-04-20.
Further reading
- Zhang W, Wang L, Liu Y, Xu J, Zhu G, Cang H, Li X, Bartlam M, Hensley K, Li G, Rao Z, Zhang XC (2009). "Structure of human lanthionine synthetase C-like protein 1 and its interaction with Eps8 and glutathione". Genes Dev. 23 (12): 1387–92. doi:10.1101/gad.1789209. PMC 2701572. PMID 19528316.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.