LHX2

Protein-coding gene in the species Homo sapiens

LHX2
Identifiers
AliasesLHX2, LH2, hLhx2, LIM homeobox 2
External IDsOMIM: 603759 MGI: 96785 HomoloGene: 55848 GeneCards: LHX2
Gene location (Human)
Chromosome 9 (human)
Chr.Chromosome 9 (human)[1]
Chromosome 9 (human)
Genomic location for LHX2
Genomic location for LHX2
Band9q33.3Start124,001,670 bp[1]
End124,033,301 bp[1]
Gene location (Mouse)
Chromosome 2 (mouse)
Chr.Chromosome 2 (mouse)[2]
Chromosome 2 (mouse)
Genomic location for LHX2
Genomic location for LHX2
Band2|2 BStart38,229,293 bp[2]
End38,259,745 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • hair follicle

  • ganglionic eminence

  • sperm

  • retinal pigment epithelium

  • endothelial cell

  • entorhinal cortex

  • middle temporal gyrus

  • Brodmann area 23

  • amygdala

  • postcentral gyrus
Top expressed in
  • olfactory epithelium

  • ganglionic eminence

  • lip

  • septum transversum

  • barrel cortex

  • hand

  • hippocampus proper

  • hepatic diverticulum

  • medial ganglionic eminence

  • prefrontal cortex
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • metal ion binding
  • sequence-specific DNA binding
  • chromatin binding
  • DNA binding
  • RNA polymerase II cis-regulatory region sequence-specific DNA binding
  • DNA-binding transcription activator activity, RNA polymerase II-specific
  • DNA-binding transcription factor activity, RNA polymerase II-specific
  • transcription factor binding
  • RNA polymerase II transcription regulatory region sequence-specific DNA binding
Cellular component
  • nucleus
  • intracellular anatomical structure
Biological process
  • negative regulation of transcription regulatory region DNA binding
  • mesoderm development
  • telencephalon development
  • neural tube closure
  • retina development in camera-type eye
  • cerebral cortex development
  • transcription, DNA-templated
  • axon guidance
  • axon extension
  • hair follicle development
  • maintenance of epithelial cell apical/basal polarity
  • neurogenesis
  • brain development
  • olfactory bulb development
  • nervous system development
  • dorsal/ventral pattern formation
  • positive regulation of transcription, DNA-templated
  • regulation of transcription, DNA-templated
  • positive regulation of transcription by RNA polymerase II
  • neuron differentiation
  • anatomical structure formation involved in morphogenesis
  • telencephalon regionalization
  • transcription by RNA polymerase II
  • negative regulation of gene expression, epigenetic
  • negative regulation of neurogenesis
  • positive regulation of neural precursor cell proliferation
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

9355

16870

Ensembl

ENSG00000106689

ENSMUSG00000000247

UniProt

P50458

Q9Z0S2

RefSeq (mRNA)

NM_004789

NM_001290646
NM_010710

RefSeq (protein)

NP_004780

NP_001277575
NP_034840

Location (UCSC)Chr 9: 124 – 124.03 MbChr 2: 38.23 – 38.26 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

LIM/homeobox protein Lhx2 is a protein that in humans is encoded by the LHX2 gene.[5][6][7]

This gene encodes a protein belonging to a large protein family, members of which carry the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein may function as a transcriptional regulator. The protein can recapitulate or rescue phenotypes in Drosophila caused by a related protein, suggesting conservation of function during evolution.[7]

Interactions

LHX2 has been shown to interact with CITED2.[8]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000106689 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000000247 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Wu HK, Heng HH, Siderovski DP, Dong WF, Okuno Y, Shi XM, Tsui LC, Minden MD (July 1996). "Identification of a human LIM-Hox gene, hLH-2, aberrantly expressed in chronic myelogenous leukaemia and located on 9q33-34.1". Oncogene. 12 (6): 1205–1212. PMID 8649822.
  6. ^ Rincon-Limas DE, Lu CH, Canal I, Calleja M, Rodriguez-Esteban C, Izpisua-Belmonte JC, Botas J (April 1999). "Conservation of the expression and function of apterous orthologs in Drosophila and mammals". Proc Natl Acad Sci U S A. 96 (5): 2165–2170. Bibcode:1999PNAS...96.2165R. doi:10.1073/pnas.96.5.2165. PMC 26754. PMID 10051612.
  7. ^ a b "Entrez Gene: LHX2 LIM homeobox 2".
  8. ^ Glenn, D J; Maurer R A (December 1999). "MRG1 binds to the LIM domain of Lhx2 and may function as a coactivator to stimulate glycoprotein hormone alpha-subunit gene expression". J. Biol. Chem. 274 (51). UNITED STATES: 36159–36167. doi:10.1074/jbc.274.51.36159. ISSN 0021-9258. PMID 10593900.

Further reading

  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Glenn DJ, Maurer RA (2000). "MRG1 binds to the LIM domain of Lhx2 and may function as a coactivator to stimulate glycoprotein hormone alpha-subunit gene expression". J. Biol. Chem. 274 (51): 36159–36167. doi:10.1074/jbc.274.51.36159. PMID 10593900.
  • Bach I, Rodriguez-Esteban C, Carrière C, et al. (1999). "RLIM inhibits functional activity of LIM homeodomain transcription factors via recruitment of the histone deacetylase complex". Nat. Genet. 22 (4): 394–399. doi:10.1038/11970. PMID 10431247. S2CID 22326394.
  • Bendall AJ, Rincón-Limas DE, Botas J, Abate-Shen C (1998). "Protein complex formation between Msx1 and Lhx2 homeoproteins is incompatible with DNA binding activity". Differentiation. 63 (3): 151–157. doi:10.1046/j.1432-0436.1998.6330151.x. PMID 9697309.
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  • 2dmq: Solution structure of the homeobox domain of LIM/homeobox protein Lhx9
    2dmq: Solution structure of the homeobox domain of LIM/homeobox protein Lhx9


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