LRRK1

Protein-coding gene in the species Homo sapiens
LRRK1
Identifiers
AliasesLRRK1, RIPK6, Roco1, leucine-rich repeat kinase 1, leucine rich repeat kinase 1, OSMD
External IDsOMIM: 610986; MGI: 2142227; HomoloGene: 23464; GeneCards: LRRK1; OMA:LRRK1 - orthologs
Gene location (Human)
Chromosome 15 (human)
Chr.Chromosome 15 (human)[1]
Chromosome 15 (human)
Genomic location for LRRK1
Genomic location for LRRK1
Band15q26.3Start100,919,327 bp[1]
End101,078,257 bp[1]
Gene location (Mouse)
Chromosome 7 (mouse)
Chr.Chromosome 7 (mouse)[2]
Chromosome 7 (mouse)
Genomic location for LRRK1
Genomic location for LRRK1
Band7|7 CStart65,876,660 bp[2]
End66,038,098 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • lymph node

  • appendix

  • transverse colon

  • spleen

  • monocyte

  • mucosa of transverse colon

  • minor salivary glands

  • skin of leg

  • rectum

  • stromal cell of endometrium
Top expressed in
  • right lung lobe

  • transitional epithelium of urinary bladder

  • left lung

  • medullary collecting duct

  • left lung lobe

  • endothelial cell of lymphatic vessel

  • conjunctival fornix

  • mesenteric lymph nodes

  • stroma of bone marrow

  • epithelium of stomach
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • kinase activity
  • transferase activity
  • nucleotide binding
  • protein kinase activity
  • GTP binding
  • protein binding
  • ATP binding
  • metal ion binding
  • identical protein binding
  • protein serine/threonine kinase activity
  • signal transducer activity
Cellular component
  • mitochondrion
  • cytoplasm
  • cytosol
Biological process
  • positive regulation of canonical Wnt signaling pathway
  • osteoclast development
  • negative regulation of peptidyl-tyrosine phosphorylation
  • positive regulation of intracellular signal transduction
  • bone resorption
  • phosphorylation
  • positive regulation of peptidyl-tyrosine phosphorylation
  • intracellular signal transduction
  • protein phosphorylation
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

79705

233328

Ensembl

ENSG00000154237

ENSMUSG00000015133

UniProt

Q38SD2

Q3UHC2

RefSeq (mRNA)

NM_024652
NM_001039843

NM_146191

RefSeq (protein)

NP_078928

NP_666303

Location (UCSC)Chr 15: 100.92 – 101.08 MbChr 7: 65.88 – 66.04 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Leucine-rich repeat serine/threonine-protein kinase 1 is an enzyme that in humans is encoded by the LRRK1 gene.[5][6][7]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000154237 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000015133 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Nagase T, Nakayama M, Nakajima D, Kikuno R, Ohara O (May 2001). "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 8 (2): 85–95. doi:10.1093/dnares/8.2.85. PMID 11347906.
  6. ^ Bosgraaf L, Van Haastert PJ (Dec 2003). "Roc, a Ras/GTPase domain in complex proteins" (PDF). Biochim Biophys Acta. 1643 (1–3): 5–10. doi:10.1016/j.bbamcr.2003.08.008. PMID 14654223. S2CID 45525061.
  7. ^ "Entrez Gene: LRRK1 leucine-rich repeat kinase 1".

Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Korr D, Toschi L, Donner P, et al. (2006). "LRRK1 protein kinase activity is stimulated upon binding of GTP to its Roc domain". Cell. Signal. 18 (6): 910–20. doi:10.1016/j.cellsig.2005.08.015. PMID 16243488.
  • Zody MC, Garber M, Sharpe T, et al. (2006). "Analysis of the DNA sequence and duplication history of human chromosome 15". Nature. 440 (7084): 671–5. Bibcode:2006Natur.440..671Z. doi:10.1038/nature04601. PMID 16572171.
  • Haugarvoll K, Toft M, Ross OA, et al. (2007). "Variants in the LRRK1 gene and susceptibility to Parkinson's disease in Norway". Neurosci. Lett. 416 (3): 299–301. doi:10.1016/j.neulet.2007.02.020. PMID 17324517. S2CID 10196943.
  • Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
  • Greggio E, Lewis PA, van der Brug MP, et al. (2007). "Mutations in LRRK2/dardarin associated with Parkinson disease are more toxic than equivalent mutations in the homologous kinase LRRK1". J. Neurochem. 102 (1): 93–102. doi:10.1111/j.1471-4159.2007.04523.x. PMID 17394548.


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