Protein-coding gene in the species Homo sapiens
| ADGRL2 |
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| Identifiers |
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| Aliases | ADGRL2, CIRL2, CL2, LEC1, LPHH1, LPHN2, adhesion G protein-coupled receptor L2 |
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| External IDs | OMIM: 607018 MGI: 2139714 HomoloGene: 22712 GeneCards: ADGRL2 |
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| Gene location (Human) |
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 | | Chr. | Chromosome 1 (human)[1] |
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| | Band | 1p31.1 | Start | 81,306,147 bp[1] |
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| End | 81,993,932 bp[1] |
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| Gene location (Mouse) |
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 | | Chr. | Chromosome 3 (mouse)[2] |
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| | Band | 3|3 H3 | Start | 148,815,583 bp[2] |
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| End | 148,990,555 bp[2] |
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| RNA expression pattern |
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| Bgee | | Human | Mouse (ortholog) |
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| Top expressed in | - right lung
- upper lobe of left lung
- left lobe of thyroid gland
- right lobe of thyroid gland
- gastric mucosa
- lower lobe of lung
- ganglionic eminence
- Achilles tendon
- gallbladder
- minor salivary glands
|
| | Top expressed in | - hand
- maxillary prominence
- left lung lobe
- renal corpuscle
- skin of back
- stria vascularis
- belly cord
- ventromedial nucleus
- abdominal wall
- otolith organ
|
| | More reference expression data |
|
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| BioGPS |  | | More reference expression data |
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| Gene ontology |
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| Molecular function | - G protein-coupled receptor activity
- transmembrane signaling receptor activity
- latrotoxin receptor activity
- signal transducer activity
- carbohydrate binding
| | Cellular component | - integral component of membrane
- membrane
- intracellular anatomical structure
- integral component of plasma membrane
- neuron projection
| | Biological process | - G protein-coupled receptor signaling pathway
- cell surface receptor signaling pathway
- signal transduction
- adenylate cyclase-activating G protein-coupled receptor signaling pathway
- brain development
| | Sources:Amigo / QuickGO |
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| Orthologs |
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| Species | Human | Mouse |
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| Entrez | | |
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| Ensembl | | |
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| UniProt | | |
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| RefSeq (mRNA) | NM_001297704
NM_001297705
NM_001297706
NM_012302
NM_001330645
|
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NM_001350698
NM_001350699
NM_001366002
NM_001366003
NM_001366004
NM_001366005
NM_001366006
NM_001366007
NM_001366008
NM_001366009
NM_001393349
NM_001393350
NM_001393351
NM_001393352
NM_001393353
NM_001393354 |
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| RefSeq (protein) | NP_001284633
NP_001284634
NP_001284635
NP_001317574
NP_036434
|
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NP_001337627
NP_001337628
NP_001352931
NP_001352932
NP_001352933
NP_001352934
NP_001352935
NP_001352936
NP_001352937
NP_001352938 |
| NP_001074767
NP_001392915
NP_001392916
NP_001392917
NP_001392918
|
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NP_001392919
NP_001392920
NP_001392921
NP_001392922
NP_001392923
NP_001392924
NP_001392925
NP_001392926
NP_001392927
NP_001392928
NP_001392929
NP_001392930
NP_001392931
NP_001392932
NP_001392933
NP_001392934
NP_001392935
NP_001392936
NP_001392937
NP_001392938
NP_001392939
NP_001392940
NP_001392947
NP_001392948 |
|
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| Location (UCSC) | Chr 1: 81.31 – 81.99 Mb | Chr 3: 148.82 – 148.99 Mb |
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| PubMed search | [3] | [4] |
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| Wikidata |
| View/Edit Human | View/Edit Mouse |
|
Latrophilin 2 is a protein that in humans is encoded by the ADGRL2 gene.[5][6]
This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane. While several transcript variants have been described, the biological validity of only one has been determined.[6]
See also
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000117114 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028184 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ White GR, Varley JM, Heighway J (Apr 2000). "Genomic structure and expression profile of LPHH1, a 7TM gene variably expressed in breast cancer cell lines". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1491 (1–3): 75–92. doi:10.1016/s0167-4781(00)00020-8. PMID 10760572.
- ^ a b "Entrez Gene: LPHN2 latrophilin 2".
Further reading
- Südhof TC (2001). "alpha-Latrotoxin and its receptors: neurexins and CIRL/latrophilins". Annual Review of Neuroscience. 24 (1): 933–62. doi:10.1146/annurev.neuro.24.1.933. PMID 11520923.
- Ushkaryov YA, Volynski KE, Ashton AC (Apr 2004). "The multiple actions of black widow spider toxins and their selective use in neurosecretion studies". Toxicon. 43 (5): 527–42. doi:10.1016/j.toxicon.2004.02.008. PMID 15066411.
- Bonaldo MF, Lennon G, Soares MB (Sep 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
- Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Oct 1998). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 5 (5): 277–86. doi:10.1093/dnares/5.5.277. PMID 9872452.
- White GR, Varley JM, Heighway J (Dec 1998). "Isolation and characterization of a human homologue of the latrophilin gene from a region of 1p31.1 implicated in breast cancer". Oncogene. 17 (26): 3513–9. doi:10.1038/sj.onc.1202487. PMID 10030676.
- Kreienkamp HJ, Zitzer H, Gundelfinger ED, Richter D, Bockers TM (Oct 2000). "The calcium-independent receptor for alpha-latrotoxin from human and rodent brains interacts with members of the ProSAP/SSTRIP/Shank family of multidomain proteins". The Journal of Biological Chemistry. 275 (42): 32387–90. doi:10.1074/jbc.C000490200. PMID 10964907.
- Bjarnadóttir TK, Fredriksson R, Höglund PJ, Gloriam DE, Lagerström MC, Schiöth HB (Jul 2004). "The human and mouse repertoire of the adhesion family of G-protein-coupled receptors". Genomics. 84 (1): 23–33. doi:10.1016/j.ygeno.2003.12.004. PMID 15203201.
- Clark TA, Schweitzer AC, Chen TX, Staples MK, Lu G, Wang H, Williams A, Blume JE (2007). "Discovery of tissue-specific exons using comprehensive human exon microarrays". Genome Biology. 8 (4): R64. doi:10.1186/gb-2007-8-4-r64. PMC 1896007. PMID 17456239.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
