Latrophilin 3

Protein-coding gene in the species Homo sapiens
ADGRL3
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

5CMN, 5AFB

Identifiers
AliasesADGRL3, CIRL3, LEC3, CL3, LPHN3, adhesion G protein-coupled receptor L3
External IDsOMIM: 616417 MGI: 2441950 HomoloGene: 22878 GeneCards: ADGRL3
Gene location (Human)
Chromosome 4 (human)
Chr.Chromosome 4 (human)[1]
Chromosome 4 (human)
Genomic location for ADGRL3
Genomic location for ADGRL3
Band4q13.1Start61,201,258 bp[1]
End62,078,335 bp[1]
Gene location (Mouse)
Chromosome 5 (mouse)
Chr.Chromosome 5 (mouse)[2]
Chromosome 5 (mouse)
Genomic location for ADGRL3
Genomic location for ADGRL3
Band5|5 D-E1Start81,020,138 bp[2]
End81,825,133 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • hair follicle

  • saphenous vein

  • middle temporal gyrus

  • endothelial cell

  • entorhinal cortex

  • superior vestibular nucleus

  • orbitofrontal cortex

  • Achilles tendon

  • Brodmann area 23

  • corpus callosum
Top expressed in
  • Region I of hippocampus proper

  • otolith organ

  • utricle

  • ventromedial nucleus

  • substantia nigra

  • lateral hypothalamus

  • medial geniculate nucleus

  • olfactory tubercle

  • piriform cortex

  • medial dorsal nucleus
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • G protein-coupled receptor activity
  • signal transducer activity
  • metal ion binding
  • protein binding
  • transmembrane signaling receptor activity
  • carbohydrate binding
  • calcium ion binding
Cellular component
  • integral component of membrane
  • cell projection
  • membrane
  • cell-cell junction
  • plasma membrane
  • axon
  • cell junction
  • integral component of plasma membrane
  • glutamatergic synapse
  • intracellular anatomical structure
Biological process
  • response to cocaine
  • G protein-coupled receptor signaling pathway
  • neuron migration
  • cell surface receptor signaling pathway
  • synapse assembly
  • locomotion involved in locomotory behavior
  • signal transduction
  • positive regulation of synapse assembly
  • cell-cell adhesion via plasma-membrane adhesion molecules
  • synapse organization
  • adenylate cyclase-activating G protein-coupled receptor signaling pathway
  • brain development
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

23284

319387

Ensembl

ENSG00000150471

ENSMUSG00000037605

UniProt

Q9HAR2

Q80TS3

RefSeq (mRNA)
NM_015236
NM_001322246
NM_001322402
NM_001371342
NM_001371343

NM_001371344
NM_001371345
NM_001371346

NM_198702
NM_001347367
NM_001347368
NM_001347369
NM_001347371

NM_001359826
NM_001359828
NM_001359829
NM_001359830
NM_001359831
NM_001359832
NM_001359833
NM_001359834

RefSeq (protein)
NP_001309175
NP_001309331
NP_056051
NP_001358271
NP_001358272

NP_001358273
NP_001358274
NP_001358275

NP_001334296
NP_001334297
NP_001334298
NP_001334300
NP_941991

NP_001346755
NP_001346757
NP_001346758
NP_001346759
NP_001346760
NP_001346761
NP_001346762
NP_001346763

Location (UCSC)Chr 4: 61.2 – 62.08 MbChr 5: 81.02 – 81.83 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Latrophilin 3 is a protein that in humans is encoded by the ADGRL3 gene.[5][6]

Function

This gene encodes a member of the latrophilin subfamily of G protein-coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane.[6]

Clinical significance

A version of this gene has been linked to attention deficit hyperactivity disorder (ADHD).[7]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000150471 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000037605 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Hayflick JS (Jan 2001). "A family of heptahelical receptors with adhesion-like domains: a marriage between two super families". Journal of Receptor and Signal Transduction Research. 20 (2–3): 119–31. doi:10.3109/10799890009150640. PMID 10994649. S2CID 19919738.
  6. ^ a b "Entrez Gene: LPHN3 latrophilin 3".
  7. ^ Arcos-Burgos M, Jain M, Acosta MT, Shively S, Stanescu H, Wallis D, et al. (Nov 2010). "A common variant of the latrophilin 3 gene, LPHN3, confers susceptibility to ADHD and predicts the effectiveness of stimulant medication". Molecular Psychiatry. 15 (11): 1053–66. doi:10.1038/mp.2010.6. hdl:11336/80502. PMID 20157310.

Further reading

  • Südhof TC (2001). "alpha-Latrotoxin and its receptors: neurexins and CIRL/latrophilins". Annual Review of Neuroscience. 24: 933–62. doi:10.1146/annurev.neuro.24.1.933. PMID 11520923.
  • Ushkaryov YA, Volynski KE, Ashton AC (Apr 2004). "The multiple actions of black widow spider toxins and their selective use in neurosecretion studies". Toxicon. 43 (5): 527–42. doi:10.1016/j.toxicon.2004.02.008. PMID 15066411.
  • Soares MB, Bonaldo MF, Jelene P, Su L, Lawton L, Efstratiadis A (Sep 1994). "Construction and characterization of a normalized cDNA library". Proceedings of the National Academy of Sciences of the United States of America. 91 (20): 9228–32. Bibcode:1994PNAS...91.9228S. doi:10.1073/pnas.91.20.9228. PMC 44785. PMID 7937745.
  • Sanger Centre, The; Washington University Genome Sequencing Cente, The (Nov 1998). "Toward a complete human genome sequence". Genome Research. 8 (11): 1097–108. doi:10.1101/gr.8.11.1097. PMID 9847074.
  • Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Oct 1998). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 5 (5): 277–86. doi:10.1093/dnares/5.5.277. PMID 9872452.
  • Kreienkamp HJ, Zitzer H, Gundelfinger ED, Richter D, Bockers TM (Oct 2000). "The calcium-independent receptor for alpha-latrotoxin from human and rodent brains interacts with members of the ProSAP/SSTRIP/Shank family of multidomain proteins". The Journal of Biological Chemistry. 275 (42): 32387–90. doi:10.1074/jbc.C000490200. PMID 10964907.
  • Bjarnadóttir TK, Fredriksson R, Höglund PJ, Gloriam DE, Lagerström MC, Schiöth HB (Jul 2004). "The human and mouse repertoire of the adhesion family of G-protein-coupled receptors". Genomics. 84 (1): 23–33. doi:10.1016/j.ygeno.2003.12.004. PMID 15203201.

External links

  • PDBe-KB provides an overview of all the structure information available in the PDB for Human Adhesion G protein-coupled receptor L3
  • PDBe-KB provides an overview of all the structure information available in the PDB for Mouse Adhesion G protein-coupled receptor L3


This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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