Leukocyte receptor tyrosine kinase

Enzyme found in humans

LTK

Identifiers

Aliases

LTK, TYK1, Leukocyte receptor tyrosine kinase

External IDs

OMIM: 151520 MGI: 96840 HomoloGene: 130502 GeneCards: LTK

Gene location (Human)

Chr.	Chromosome 15 (human)^[1]

Band	15q15.1	Start	41,503,637 bp^[1]
Band	15q15.1	End	41,513,887 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 2 (mouse)^[2]

Band	2 E5\|2 59.97 cM	Start	119,581,801 bp^[2]
Band	2 E5\|2 59.97 cM	End	119,590,912 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

right lung

parotid gland

upper lobe of left lung

duodenum

rectum

jejunal mucosa

body of stomach

spleen

gallbladder

right lobe of liver

Top expressed in

entorhinal cortex

visual cortex

olfactory epithelium

superior frontal gyrus

primary motor cortex

substantia nigra

spermatocyte

prefrontal cortex

spermatid

cingulate gyrus

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	transferase activity protein kinase activity nucleotide binding kinase activity transmembrane receptor protein tyrosine kinase activity protein tyrosine kinase activity ATP binding protein binding receptor tyrosine kinase transmembrane signaling receptor activity
Cellular component	integral component of membrane membrane plasma membrane integral component of plasma membrane intracellular anatomical structure cytoplasm receptor complex
Biological process	cellular response to retinoic acid phosphorylation transmembrane receptor protein tyrosine kinase signaling pathway positive regulation of cardiac muscle cell apoptotic process negative regulation of apoptotic process protein phosphorylation positive regulation of neuron projection development phosphatidylinositol 3-kinase signaling cell population proliferation peptidyl-tyrosine phosphorylation signal transduction negative regulation of signal transduction cell differentiation positive regulation of ERK1 and ERK2 cascade regulation of neuron differentiation
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


4058


17005

Ensembl


ENSG00000062524


ENSMUSG00000027297

UniProt


P29376


P08923

RefSeq (mRNA)


NM_001135685 NM_002344 NM_206961


NM_008523 NM_203345 NM_206941 NM_206942

RefSeq (protein)


NP_001129157 NP_002335 NP_996844


NP_032549 NP_976220 NP_996824 NP_996825

Location (UCSC)

Chr 15: 41.5 – 41.51 Mb

Chr 2: 119.58 – 119.59 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Leukocyte receptor tyrosine kinase is an enzyme that in humans is encoded by the LTK gene.^[5]^[6]

Function

The protein encoded by this gene is a member of the ALK/LTK receptor family of receptor tyrosine kinases (RTKs) whose ligand is unknown.^[7] Closely related to the insulin receptor family of RTKs. Tyrosine-specific phosphorylation of proteins is a key to the control of diverse pathways leading to cell growth and differentiation. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.^[6]

Interactions

LTK has been shown to interact with IRS-1, Shc, and PIK3R1.^[8]^[9]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000062524 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000027297 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Maru Y, Hirai H, Takaku F (May 1990). "Human ltk: gene structure and preferential expression in human leukemic cells". Oncogene Res. 5 (3): 199–204. PMID 2320375.
^ ^a ^b "Entrez Gene: LTK leukocyte tyrosine kinase".
^ Lopes SS, Yang X, Müller J, Carney TJ, McAdow AR, Rauch GJ, Jacoby AS, Hurst LD, Delfino-Machín M, Haffter P, Geisler R, Johnson SL, Ward A, Kelsh RN (2008). "Leukocyte tyrosine kinase functions in pigment cell development". PLOS Genet. 4 (3): e1000026. doi:10.1371/journal.pgen.1000026. PMC 2265441. PMID 18369445.
^ Kozutsumi H, Toyoshima H, Hagiwara K, Yazaki Y, Hirai H (October 1994). "Human ltk receptor tyrosine kinase binds to PLC-gamma 1, PI3-K, GAP and Raf-1 in vivo". Oncogene. 9 (10): 2991–8. PMID 8084603.
^ Ueno H, Honda H, Nakamoto T, Yamagata T, Sasaki K, Miyagawa K, Mitani K, Yazaki Y, Hirai H (June 1997). "The phosphatidylinositol 3' kinase pathway is required for the survival signal of leukocyte tyrosine kinase". Oncogene. 14 (25): 3067–72. doi:10.1038/sj.onc.1201153. PMID 9223670.

Krolewski JJ, Dalla-Favera R (1991). "The ltk gene encodes a novel receptor-type protein tyrosine kinase". EMBO J. 10 (10): 2911–9. doi:10.1002/j.1460-2075.1991.tb07841.x. PMC 453005. PMID 1655406.
Krolewski JJ, Lee R, Eddy R, Shows TB, Dalla-Favera R (1990). "Identification and chromosomal mapping of new human tyrosine kinase genes". Oncogene. 5 (3): 277–82. PMID 2156206.
Ben-Neriah Y, Bauskin AR (1988). "Leukocytes express a novel gene encoding a putative transmembrane protein-kinase devoid of an extracellular domain". Nature. 333 (6174): 672–6. Bibcode:1988Natur.333..672B. doi:10.1038/333672a0. PMID 2836739. S2CID 4262549.
Toyoshima H, Kozutsumi H, Maru Y, Hagiwara K, Furuya A, Mioh H, Hanai N, Takaku F, Yazaki Y, Hirai H (1993). "Differently spliced cDNAs of human leukocyte tyrosine kinase receptor tyrosine kinase predict receptor proteins with and without a tyrosine kinase domain and a soluble receptor protein". Proc. Natl. Acad. Sci. U.S.A. 90 (12): 5404–8. Bibcode:1993PNAS...90.5404T. doi:10.1073/pnas.90.12.5404. PMC 46728. PMID 7685902.
Richard I, Broux O, Chiannilkulchai N, Fougerousse F, Allamand V, Bourg N, Brenguier L, Devaud C, Pasturaud P, Roudaut C (1995). "Regional localization of human chromosome 15 loci". Genomics. 23 (3): 619–27. doi:10.1006/geno.1994.1550. PMID 7851890.
Kozutsumi H, Toyoshima H, Hagiwara K, Yazaki Y, Hirai H (1994). "Human ltk receptor tyrosine kinase binds to PLC-gamma 1, PI3-K, GAP and Raf-1 in vivo". Oncogene. 9 (10): 2991–8. PMID 8084603.
Kozutsumi H, Toyoshima H, Hagiwara K, Furuya A, Mioh H, Hanai N, Yazaki Y, Hirai H (1993). "Identification of the human ltk gene product in placenta and hematopoietic cell lines". Biochem. Biophys. Res. Commun. 190 (2): 674–9. doi:10.1006/bbrc.1993.1101. PMID 8427607.
Ueno H, Sasaki K, Kozutsumi H, Miyagawa K, Mitani K, Yazaki Y, Hirai H (1996). "Growth and survival signals transmitted via two distinct NPXY motifs within leukocyte tyrosine kinase, an insulin receptor-related tyrosine kinase". J. Biol. Chem. 271 (44): 27707–14. doi:10.1074/jbc.271.44.27707. PMID 8910363.
Snijders AJ, Ho SC, Haase VH, Pillai S, Bernards A (1997). "A lymphocyte-specific Ltk tyrosine kinase isoform is retained in the endoplasmic reticulum in association with calnexin". J. Biol. Chem. 272 (2): 1297–301. doi:10.1074/jbc.272.2.1297. PMID 8995435.
Ueno H, Honda H, Nakamoto T, Yamagata T, Sasaki K, Miyagawa K, Mitani K, Yazaki Y, Hirai H (1997). "The phosphatidylinositol 3' kinase pathway is required for the survival signal of leukocyte tyrosine kinase". Oncogene. 14 (25): 3067–72. doi:10.1038/sj.onc.1201153. PMID 9223670.
Espanel X, Huguenin-Reggiani M, Hooft van Huijsduijnen R (2003). "The SPOT technique as a tool for studying protein tyrosine phosphatase substrate specificities". Protein Sci. 11 (10): 2326–34. doi:10.1110/ps.0213402. PMC 2373693. PMID 12237455.
Li N, Nakamura K, Jiang Y, Tsurui H, Matsuoka S, Abe M, Ohtsuji M, Nishimura H, Kato K, Kawai T, Atsumi T, Koike T, Shirai T, Ueno H, Hirose S (2004). "Gain-of-function polymorphism in mouse and human Ltk: implications for the pathogenesis of systemic lupus erythematosus". Hum. Mol. Genet. 13 (2): 171–9. doi:10.1093/hmg/ddh020. PMID 14695357.

Protein kinases: tyrosine kinases (EC 2.7.10)

Receptor tyrosine kinases (EC 2.7.10.1)

Growth factor receptors

EGF receptor family	EGFR ERBB2 ERBB3 ERBB4
Insulin receptor family	IGF1R INSR INSRR
PDGF receptor family	CSF1R FLT3 KIT PDGFR (PDGFRA PDGFRB)
FGF receptor family	FGFR1 FGFR2 FGFR3 FGFR4
VEGF receptors family	VEGFR1 VEGFR2 VEGFR3
HGF receptor family	MET RON
Trk receptor family	NTRK1 NTRK2 NTRK3

EPH receptor family

LTK receptor family

TIE receptor family

ROR receptor family

ROR1
ROR2

DDR receptor family

DDR1
DDR2

PTK7 receptor family

PTK7

RYK receptor family

MuSK receptor family

MUSK

ROS receptor family

ROS1

AATYK receptor family

AATYK
AATYK2

AXL receptor family

RET receptor family

uncategorised

STYK1

Non-receptor tyrosine kinases (EC 2.7.10.2)

ABL family	ABL1 ARG
ACK family	ACK1 TNK1
CSK family	CSK MATK
FAK family	FAK PYK2
FES family	FES FER
FRK family	FRK BRK SRMS
JAK family	JAK1 JAK2 JAK3 TYK2
SRC-A family	SRC FGR FYN YES1
SRC-B family	BLK HCK LCK LYN
TEC family	TEC BMX BTK ITK TXK
SYK family	SYK ZAP70

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)