Liarozole

Liarozole
Names

Preferred IUPAC name 6-[(3-Chlorophenyl)(1H-imidazol-1-yl)methyl]-1H-1,3-benzimidazole
Identifiers
CAS Number	115575-11-6^Y
3D model (JSmol)	Interactive image
ChemSpider	54664
IUPHAR/BPS	5210
PubChem CID	60652
UNII	K0Q29TGV9Y^Y
CompTox Dashboard (EPA)	DTXSID9048277
InChI InChI=1S/C17H13ClN4/c18-14-3-1-2-12(8-14)17(22-7-6-19-11-22)13-4-5-15-16(9-13)21-10-20-15/h1-11,17H,(H,20,21) Key: UGFHIPBXIWJXNA-UHFFFAOYSA-N InChI=1/C17H13ClN4/c18-14-3-1-2-12(8-14)17(22-7-6-19-11-22)13-4-5-15-16(9-13)21-10-20-15/h1-11,17H,(H,20,21) Key: UGFHIPBXIWJXNA-UHFFFAOYAV
SMILES C1=CC(=CC(=C1)Cl)C(C2=CC3=C(C=C2)N=CN3)N4C=CN=C4
Properties
Chemical formula	C₁₇H₁₃ClN₄
Molar mass	308.77 g·mol⁻¹
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

Chemical compound

Liarozole is a retinoic acid metabolism-blocking drug and aromatase inhibitor.^[1] Liarozole is an isomer of alprazolam, but the two compounds are completely unrelated.

References

^ Vahlquist, A; Blockhuys, S; Steijlen, P; Van Rossem, K; Didona, B; Blanco, D; Traupe, H (2013). "Oral liarozole in the treatment of patients with moderate/severe lamellar ichthyosis: Results of a randomized, double-blind, multinational, placebo-controlled phase II/III trial". The British Journal of Dermatology. 170 (1): 173–81. doi:10.1111/bjd.12626. PMC 4232915. PMID 24102348.

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Retinoid receptor modulators

RARTooltip Retinoic acid receptor

Agonists: 9CDHRA
9-cis-Retinoic acid (alitretinoin)
AC-261066
AC-55649
Acitretin
Adapalene
all-trans-Retinoic acid (tretinoin)
AM-580
BMS-493
BMS-753
BMS-961
CD-1530
CD-2314
CD-437
Ch-55
EC 23
Etretinate
Fenretinide
Isotretinoin
Palovarotene
Retinoic acid
Retinol (vitamin A)
Tamibarotene
Tazarotene
Tazarotenic acid
Trifarotene
TTNPB

Antagonists: BMS-195614
BMS-493
CD-2665
ER-50891
LE-135
MM-11253

Retinoic acid metabolism inhibitors: Liarozole

RXRTooltip Retinoid X receptor

Agonists: 9CDHRA
9-cis-Retinoic acid (alitretinoin)
all-trans-Retinoic acid (tretinoin)
Bexarotene
CD 3254
Docosahexaenoic acid
Fluorobexarotene
Isotretinoin
LG-100268
LG-101506
LG-100754
Retinoic acid
Retinol (vitamin A)
SR-11237

Antagonists: HX-531
HX-630
LG-100754
PA-452
UVI-3003
HX-603
LE135 (RAR beta selective)
LE-540
CD3254
PA-451
PA-452
Rhein
HX-711
6-(N-ethyl-N-(5-isobutoxy-4-isopropyl-2-(E)-styrylphenyl)amino)nicotinic acid

See also: Receptor/signaling modulators

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