| # | Date | Film | Gross | Notes |
| 1 | January 6, 2008 | National Treasure: Book of Secrets | $123,862 | |
| 2 | January 13, 2008 | Enchanted | $107,061 | |
| 3 | January 20, 2008 | I Am Legend | $312,762 | |
| 4 | January 27, 2008 | $154,075 | |
| 5 | February 3, 2008 | $115,174 | |
| 6 | February 10, 2008 | Cloverfield | $95,123 | |
| 7 | February 17, 2008 | The Water Horse: Legend of the Deep | $93,698 | |
| 8 | February 24, 2008 | $70,187 | |
| 9 | March 2, 2008 | American Gangster | $80,601 | |
| 10 | March 9, 2008 | 10,000 BC | $309,515 | |
| 11 | March 16, 2008 | $224,902 | |
| 12 | March 23, 2008 | $156,789 | |
| 13 | March 30, 2008 | 31 minutos | $286,427 | |
| 14 | April 6, 2008 | $220,985 | |
| 15 | April 13, 2008 | $121,552 | |
| 16 | April 20, 2008 | $106,283 | |
| 17 | April 27, 2008 | $72,801 | |
| 18 | May 4, 2008 | Iron Man | $527,314 | |
| 19 | May 11, 2008 | $185,4051 | |
| 20 | May 18, 2008 | The Chronicles of Narnia: Prince Caspian | $539,888 | |
| 21 | May 25, 2008 | Indiana Jones and the Kingdom of the Crystal Skull | $483,914 | |
| 22 | June 1, 2008 | $296,499 | |
| 23 | June 8, 2008 | The Chronicles of Narnia: Prince Caspian | $209,544 | |
| 24 | June 15, 2008 | The Happening | $223,054 | |
| 25 | June 22, 2008 | Get Smart | $192,453 | |
| 26 | June 29, 2008 | Wall-E | $545,035 | |
| 27 | July 6, 2008 | $435,033 | |
| 28 | July 13, 2008 | Kung Fu Panda | $508,559 | |
| 29 | July 20, 2008 | The Dark Knight | $805,318 | |
| 30 | July 27, 2008 | $604,025 | |
| 31 | August 3, 2008 | The Mummy: Tomb of the Dragon Emperor | $443,260 | |
| 32 | August 10, 2008 | Journey to the Center of the Earth | $319,620 | |
| 33 | August 17, 2008 | $305,775 | |
| 34 | August 24, 2008 | $151,955 | |
| 35 | August 31, 2008 | $149,051 | |
| 36 | September 7, 2008 | $114,406 | |
| 37 | September 14, 2008 | You Don't Mess with the Zohan | $114,298 | |
| 38 | September 21, 2008 | Journey to the Center of the Earth | $89,661 | |
| 39 | September 28, 2008 | $81,495 | |
| 40 | October 5, 2008 | Mirrors | $83,802 | |
| 41 | October 12, 2008 | $64,361 | |
| 42 | October 19, 2008 | Mamma Mia! | $92,675 | |
| 43 | October 26, 2008 | $47,239 | |
| 44 | November 2, 2008 | $63,630 | |
| 45 | November 9, 2008 | Quantum of Solace | $259,998 | |
| 46 | November 16, 2008 | $154,842 | |
| 47 | November 23, 2008 | High School Musical 3: Senior Year | $226,153 | High School Musical 3: Senior Year is the highest weekend opening for a musical film. |
| 48 | November 30, 2008 | $115,978 | |
| 49 | December 7, 2008 | Madagascar: Escape 2 Africa | $402,766 | |
| 50 | December 14, 2008 | The Day the Earth Stood Still | $243,095 | |
| 51 | December 21, 2008 | Madagascar: Escape 2 Africa | $178,780 | |
| 52 | December 28, 2008 | Bolt | $269,313 | |
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