| # | Date | Film | Gross (USD) | Openings in the top ten |
| 1 | January 3, 2016 | Alvin and the Chipmunks: The Road Chip | $2,483,602 | Concussion (#3), Solace (#5), El Cumple de la Abuela (#8) |
| 2 | January 10, 2016 | Point Break | $1,923,839 | Joy (#5), Summer Camp (#7), The Big Short (#8) |
| 3 | January 17, 2016 | $1,193,286 | The Danish Girl (#2), Mortadelo and Filemon: Mission Implausible (#4), Pay the Ghost (#7) |
| 4 | January 24, 2016 | The Revenant | $4,485,305 | |
| 5 | January 31, 2016 | Daddy's Home | $2,421,009 | The 5th Wave (#3), The Boy (#4), Creed (#5) |
| 6 | February 7, 2016 | $1,297,703 | Norm of the North (#5), Fifty Shades of Black (#8), The Hateful Eight (#9), Pride and Prejudice and Zombies (#10) |
| 7 | February 14, 2016 | Deadpool | $7,226,374 | Busco Novio Para mi Mujer (#2), Visions (#9), Carol (#10) |
| 8 | February 21, 2016 | Zootopia | $4,564,709 | How to Be Single (#3), The Forest (#5), Room (#6) |
| 9 | February 28, 2016 | $3,291,823 | Gods of Egypt (#3), Zoolander 2 (#4), Las Aparicio: La Película (#5), The Finest Hours (#6) |
| 10 | March 6, 2016 | $2,403,856 | Dirty Grandpa (#4), Backtrack (#6), 13 Hours: The Secret Soldiers of Benghazi (#8), The Choice (#9) |
| 11 | March 13, 2016 | Kung Fu Panda 3 | $5,172,092 | London Has Fallen (#3), Paraíso Perdido (#7), The Young Messiah (#9) |
| 12 | March 20, 2016 | $3,002,381 | The Divergent Series: Allegiant (#2), Risen (#6), Irrational Man (#10) |
| 13 | March 27, 2016 | Batman v Superman: Dawn of Justice | $12,256,287 | My Big Fat Greek Wedding 2 (#5), Capture the Flag (#6), Truth (#10) |
| 14 | April 3, 2016 | $5,386,095 | Compadres (#2), Miracles from Heaven (#3), Eddie the Eagle (#5) |
| 15 | April 10, 2016 | The Huntsman: Winter's War | $2,777,671 | The Jungle Book 3D (#3), Burnt (#7), Chronic (#9) |
| 16 | April 17, 2016 | The Jungle Book | $6,588,342 | 10 Cloverfield Lane (#4), Desierto (#5), Boruto: Naruto the Movie (#8) |
| 17 | April 24, 2016 | $5,282,187 | Eye in the Sky (#3), Before I Wake (#5), Sundown (#9), God's Not Dead 2 (#10) |
| 18 | May 1, 2016 | Captain America: Civil War | $20,472,106 | Youth (#9) |
| 19 | May 8, 2016 | $6,770,483 | Mother's Day (#3), The Other Side of the Door (#4), My King (#10) |
| 20 | May 15, 2016 | ¿Qué Culpa Tiene el Niño? | $3,582,114 | The Angry Birds Movie (#2) |
| 21 | May 22, 2016 | X-Men: Apocalypse | $6,982,357 | The Witch (#4), Rumbos Paralelos (#6), Labyrinth of Lies (#8) |
| 22 | May 29, 2016 | Alice Through the Looking Glass | $4,545,297 | Neighbors 2: Sorority Rising (#4), Fathers and Daughters (#7) |
| 23 | June 5, 2016 | Teenage Mutant Ninja Turtles: Out of the Shadows | $3,721,182 | Tini: El Gran Cambio de Violetta (#8) |
| 24 | June 12, 2016 | The Conjuring 2 | $7,458,608 | A Hologram for the King (#6), De Surprise (#9), Ratchet & Clank (#10) |
| 25 | June 19, 2016 | $3,447,284 | Warcraft (#2), Money Monster (#5), Pinocchio (#8) |
| 26 | June 26, 2016 | Independence Day: Resurgence | $6,807,844 | Me Before You (#2) |
| 27 | July 3, 2016 | Ice Age: Collision Course | $8,453,629 | Central Intelligence (#4), La Niña De La Mina (#6), Louder Than Bombs (#9) |
| 28 | July 10, 2016 | The Legend of Tarzan | $4,519,253 | The Nice Guys (#6), The Faith of Anna Waters (#7), Julieta (#9) |
| 29 | July 17, 2016 | Finding Dory | $9,537,312 | The Shallows (#4) |
| 30 | July 24, 2016 | $4,090,870 | Now You See Me 2 (#2), Criminal (#5), Cell (#9) |
| 31 | July 31, 2016 | The Secret Life of Pets | $7,496,779 | Lights Out (#2), The Wave (#6), Batman: The Killing Joke (#10) |
| 32 | August 7, 2016 | Suicide Squad | $10,346,298 | The Whole Truth (#6), East Side Sushi (#10) |
| 33 | August 14, 2016 | $4,371,410 | Ghostbusters (#2), The BFG (#4), Free State of Jones (#9) |
| 34 | August 21, 2016 | Ben-Hur | $2,683,725 | The Purge: Election Year (#3), Me Estás Matando Susana (#7), Skiptrace (#9) |
| 35 | August 28, 2016 | Jason Bourne | $1,507,072 | Bad Moms (#5) |
| 36 | September 4, 2016 | Mike and Dave Need Wedding Dates | $1,023,116 | Nine Lives (#6), Nerve (#7) |
| 37 | September 11, 2016 | Star Trek Beyond | $1,286,108 | Mechanic: Resurrection (#2) |
| 38 | September 18, 2016 | No Manches Frida | $3,226,095 | Pete's Dragon (#2), Don't Breathe (#3), Bridget Jones's Baby (#4) |
| 39 | September 25, 2016 | Storks | $2,425,893 | Bastille Day (#5), The Magnificent Seven (#7), The Light Between Oceans (#9), 7:19 (#10) |
| 40 | October 2, 2016 | Miss Peregrine's Home for Peculiar Children | $3,603,032 | Deepwater Horizon (#4), Blair Witch (#5) |
| 41 | October 9, 2016 | Treintona, Soltera y Fantástica | $2,364,087 | Kubo and the Two Strings (#5), Blood Father (#8), Sausage Party (#9), Viral (#10) |
| 42 | October 16, 2016 | Inferno | $2,545,428 | Masterminds (#5) |
| 43 | October 23, 2016 | Ouija: Origin of Evil | $2,211,371 | La Leyenda del Chupacabras (#2), La Vida Inmoral de la Pareja Ideal (#6), The Infiltrator (#8) |
| 44 | October 30, 2016 | Doctor Strange | $4,608,705 | El Jeremías (#4) |
| 45 | November 6, 2016 | Trolls | $2,645,678 | The Accountant (#3), KM 31-2 (#4), Until Forever (#10) |
| 46 | November 13, 2016 | $1,661,909 | The Girl on the Train (#3), Arrival (#5), Macho (#6), Robinson Crusoe (#8) |
| 47 | November 20, 2016 | Fantastic Beasts and Where to Find Them | $5,774,215 | The 9th Life of Louis Drax (#8), Café Society (#9) |
| 48 | November 27, 2016 | $2,602,427 | Jack Reacher: Never Go Back (#2), Shut In (#4), Keeping Up with the Joneses (#5) |
| 49 | December 4, 2016 | Moana | $2,880,517 | Underworld: Blood Wars (#2), Sully (#3), Qué Pena Tu Vida (#5) |
| 50 | December 11, 2016 | $2,359,271 | Office Christmas Party (#2), Train to Busan (#6), Blackway (#10) |
| 51 | December 18, 2016 | Rogue One: A Star Wars Story | $5,129,571 | Collateral Beauty (#2), The Disappointments Room (#5) |
| 52 | December 25, 2016 | Sing | $1,701,157 | Passengers (#3), Un Padre No Tan Padre (#4), Why Him? (#7) |
| 53 | January 1, 2017 | $1,552,491 | Ballerina (#4), Hacksaw Ridge (#6), Assassin's Creed (#8) |
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