| Title | Director | Cast | Genre | Notes |
| The Abandoned | Nacho Cerdà | Anastasia Hille, Karel Roden | Horror | Co-production with Spain |
| Alien Autopsy | Jonny Campbell | Ant & Dec, Jimmy Carr | Comedy | |
| Amazing Grace | Michael Apted | Ioan Gruffudd, Albert Finney | Biopic | |
| Antonio's Breakfast | Daniel Mulloy | George Irving | Short | Academy Award for Best Short |
| As You Like It | Kenneth Branagh | Romola Garai, Alfred Molina | Comedy | |
| Basic Instinct 2 | Michael Caton-Jones | Sharon Stone, David Morrissey | Thriller | |
| Breaking and Entering | Anthony Minghella | Jude Law, Juliette Binoche | Romantic drama | |
| Cashback | Sean Ellis | Sean Biggerstaff, Emilia Fox | Drama | |
| Casino Royale | Martin Campbell | Daniel Craig, Eva Green, Mads Mikkelsen | Spy/action | Reboot of the James Bond franchise |
| Children of Men | Alfonso Cuarón | Julianne Moore, Clive Owen | Sci-fi | |
| A Cock and Bull Story | Michael Winterbottom | Steve Coogan, Rob Brydon, Keeley Hawes | Comedy | |
| Colour Me Kubrick | Michael Fitzgerald | John Malkovich, Richard E. Grant | Comedy | |
| Confetti | Debbie Isitt | Martin Freeman, Jessica Stevenson | Mockumentary | |
| Driving Lessons | Jeremy Brock | Julie Walters, Rupert Grint, Laura Linney | Comedy/drama | Entered into the 28th Moscow International Film Festival |
| The Flying Scotsman | Douglas Mackinnon | Jonny Lee Miller, Laura Fraser | Sports | |
| A Good Year | Ridley Scott | Russell Crowe | Romantic comedy | Based on the novel A Good Year by Peter Mayle |
| Half Light | Craig Rosenberg | Demi Moore, Hans Matheson | Thriller | |
| The History Boys | Nicholas Hytner | Richard Griffiths, Domonic Cooper | Drama | |
| The Kovak Box | Daniel Monzón | Timothy Hutton, Lucía Jiménez | Thriller | Co-production with Spain |
| The Last King of Scotland | Kevin Macdonald | Forest Whitaker, James McAvoy | Drama | Won Academy Award for Best Actor |
| London to Brighton | Paul Andrew Williams | Lorraine Stanley, Georgia Groome | Crime/drama | |
| Love and Other Disasters | Alek Keshishian | Brittany Murphy, Matthew Rhys, Catherine Tate | Comedy/romance | Co-production with France |
| Notes on a Scandal (film) | Richard Eyre | Judi Dench, Cate Blanchett | Drama | |
| Once | Glen Hansard, Marketa Irglova | | Music/drama/romance | Won an Academy Award |
| Peter and the Wolf | Suzie Templeton | | Animated short | Won Academy Award for Best Short Film (Animated) |
| Pierrepoint | Adrian Shergold | Timothy Spall, Juliet Stevenson | Drama | |
| Played | Sean Stanek | Val Kilmer, Mick Rossi | Crime | |
| The Queen | Stephen Frears | Helen Mirren, Michael Sheen | Drama | Winner of the Academy Award and Golden Globe for Best Actress and BAFTA for Best Film and Best Actress |
| Queer Duck: The Movie | Xeth Feinberg | Jim J. Bullock, Jackie Hoffman, Kevin Michael Richardson, Billy West, Maurice LaMarche, Jeff Bennett, Tim Curry, Conan O'Brien, David Duchovny | Animated | |
| Red Road | Andrea Arnold | Kate Dickie, Tony Curran, Martin Compston, Natalie Press | Thriller | Won the Jury Prize at the 2006 Cannes Film Festival |
| Scenes of a Sexual Nature | Ed Blum | Holly Aird, Eileen Atkins | Comedy/drama | |
| Scoop | Woody Allen | Woody Allen, Scarlett Johansson, Hugh Jackman, Ian McShane | Romantic comedy/mystery | |
| Severance | Christopher Smith | Danny Dyer, Laura Harris, Tim McInnerny | Comedy horror | British/German co-production |
| Starter for 10 | Tom Vaughan | James McAvoy, Alice Eve, Rebecca Hall | Comedy drama | based on Starter for Ten by David Nicholls |
| Stormbreaker | Geoffrey Sax | Alex Pettyfer, Mickey Rourke | Adventure | |
| The Thief Lord | Richard Claus [de] | Aaron Taylor-Johnson, Rollo Weeks, Vanessa Redgrave | Adventure | Co-production with Germany |
| Three | Stewart Raffill | Billy Zane, Kelly Brook | Drama | |
| Tirant lo Blanc | Vicente Aranda | Victoria Abril, Leonor Watling, Jane Asher | Adventure | Co-production with Italy and Spain |
| United 93 | Paul Greengrass | J.J. Johnson, Gary Commock, Polly Adams | Drama | Winner of BAFTA for Best Director |
| Venus | Roger Michell | Peter O'Toole, Leslie Phillips | Drama | |
| Wild Country | Craig Strachan | Martin Compston, Peter Capaldi, Samantha Shields | Horror | |
| The Wind That Shakes the Barley | Ken Loach | Cillian Murphy, Padraic Delaney | War | |
| A Woman in Winter | Richard Jobson | Jamie Sives, Julie Gayet | Drama | [1] |
| Flushed Away | Sam Fell and David Bowers | | | Co-production with USA |
| Rock-a-Snowy (PG-13) film | Chris Wedge | Anne Hathaway, John Goodman, Mike Myers | Animation | |
