Lophophine

Legal statusLegal status IdentifiersCAS NumberPubChem CIDChemSpiderUNIIChEMBLCompTox Dashboard (EPA)ECHA InfoCard100.041.645 Chemical and physical dataFormulaC₁₀H₁₃NO₃Molar mass195.218 g·mol⁻¹3D model (JSmol)  (verify)

Lophophine (MMDPEA or 3-methoxy-4,5-methylenedioxyphenethylamine) is a putative psychedelic and entactogen drug of the methylenedioxyphenethylamine class. It is the α-demethylated homologue of MMDA, and is also closely related to mescaline.

Alexander Shulgin originally suggested that lophophine may be a natural constituent of peyote (Lophophora williamsii) due to it being the only logical chemical intermediate for the biosynthesis of several tetrahydroisoquinolines known to be present in this cactus species.^[1] Subsequently, lophophine was indeed shown to be a minor component of both peyote and San Pedro cactus.^[2]

Shulgin reports that lophophine is active in the dosage range of 150–250 mg. He states that at these doses, lophophine has some similarity to mescaline in action, in producing a peaceful elevation of mood, euphoria, and mild enhancement of visual perception, but without the generation of closed-eye mental imagery. Shulgin also notes that (in contrast to mescaline), lophophine causes no nausea.^[1]

See also

• MDPEA

References

External links

• PiHKAL: #95 Lophophine: 3-Methoxy-4,5-methylenedioxyphenethylamine
• Mescaline: The Chemistry and Pharmacology of its Analogues Archived 2014-02-16 at the Wayback Machine