MAP1B

Protein-coding gene in the species Homo sapiens
MAP1B
Identifiers
AliasesMAP1B, FUTSCH, MAP5, PPP1R102, microtubule-associated protein 1B, microtubule associated protein 1B, PVNH9, DFNA83
External IDsOMIM: 157129 MGI: 1306778 HomoloGene: 38111 GeneCards: MAP1B
Gene location (Human)
Chromosome 5 (human)
Chr.Chromosome 5 (human)[1]
Chromosome 5 (human)
Genomic location for MAP1B
Genomic location for MAP1B
Band5q13.2Start72,107,234 bp[1]
End72,209,565 bp[1]
Gene location (Mouse)
Chromosome 13 (mouse)
Chr.Chromosome 13 (mouse)[2]
Chromosome 13 (mouse)
Genomic location for MAP1B
Genomic location for MAP1B
Band13 D1|13 52.9 cMStart99,557,954 bp[2]
End99,653,048 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • middle temporal gyrus

  • Brodmann area 23

  • superior vestibular nucleus

  • pons

  • external globus pallidus

  • parietal lobe

  • postcentral gyrus

  • entorhinal cortex

  • spinal ganglia

  • ventral tegmental area
Top expressed in
  • facial motor nucleus

  • anterior horn of spinal cord

  • median eminence

  • substantia nigra

  • medial dorsal nucleus

  • habenula

  • medial vestibular nucleus

  • pontine nuclei

  • medial geniculate nucleus

  • arcuate nucleus
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • microtubule binding
  • structural molecule activity
  • protein binding
  • actin binding
  • tubulin binding
  • phospholipid binding
  • protein-containing complex binding
Cellular component
  • cell projection
  • postsynaptic density
  • plasma membrane
  • dendritic spine
  • photoreceptor outer segment
  • synapse
  • microtubule associated complex
  • cell junction
  • microtubule
  • cytoskeleton
  • cytoplasm
  • cytosol
  • axon
  • dendrite
  • somatodendritic compartment
  • neuronal cell body
  • apical dendrite
  • basal dendrite
  • hippocampal mossy fiber
  • growth cone
  • varicosity
  • perikaryon
  • perinuclear region of cytoplasm
Biological process
  • negative regulation of intracellular transport
  • axonogenesis
  • dendrite development
  • nervous system development
  • microtubule bundle formation
  • axon extension
  • positive regulation of axon extension
  • mitochondrion transport along microtubule
  • establishment of monopolar cell polarity
  • cellular process
  • microtubule cytoskeleton organization
  • neuron migration
  • regulation of microtubule depolymerization
  • negative regulation of microtubule depolymerization
  • synapse assembly
  • response to wounding
  • response to mechanical stimulus
  • response to carbohydrate
  • response to inorganic substance
  • peripheral nervous system axon regeneration
  • response to insecticide
  • developmental maturation
  • positive regulation of microtubule polymerization
  • response to nutrient levels
  • response to estradiol
  • response to vitamin A
  • positive regulation of neuron differentiation
  • neuron development
  • response to axon injury
  • induction of synaptic plasticity by chemical substance
  • cellular response to growth factor stimulus
  • cellular response to peptide hormone stimulus
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

4131

17755

Ensembl

ENSG00000131711

ENSMUSG00000052727

UniProt

P46821

P14873

RefSeq (mRNA)

NM_005909
NM_032010
NM_001324255

NM_008634

RefSeq (protein)

NP_001311184
NP_005900

NP_032660

Location (UCSC)Chr 5: 72.11 – 72.21 MbChr 13: 99.56 – 99.65 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Microtubule-associated protein 1B is a protein that in humans is encoded by the MAP1B gene.[5][6]

Function

This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The product of this gene is a precursor polypeptide that presumably undergoes proteolytic processing to generate the final MAP1B heavy chain and LC1 light chain. Gene knockout studies of the mouse microtubule-associated protein 1B gene suggested an important role in development and function of the nervous system. Two alternatively spliced transcript variants have been described.[6]

Interactions

MAP1B has been shown to interact with Acidic leucine-rich nuclear phosphoprotein 32 family member A[7] and RASSF1.[8]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000131711 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000052727 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Lien LL, Boyce FM, Kleyn P, Brzustowicz LM, Menninger J, Ward DC, Gilliam TC, Kunkel LM (Oct 1991). "Mapping of human microtubule-associated protein 1B in proximity to the spinal muscular atrophy locus at 5q13". Proc. Natl. Acad. Sci. U.S.A. 88 (17): 7873–6. Bibcode:1991PNAS...88.7873L. doi:10.1073/pnas.88.17.7873. PMC 52406. PMID 1881920.
  6. ^ a b "Entrez Gene: MAP1B microtubule-associated protein 1B".
  7. ^ Opal P, Garcia JJ, Propst F, Matilla A, Orr HT, Zoghbi HY (Sep 2003). "Mapmodulin/leucine-rich acidic nuclear protein binds the light chain of microtubule-associated protein 1B and modulates neuritogenesis". J. Biol. Chem. 278 (36): 34691–9. doi:10.1074/jbc.M302785200. PMID 12807913.
  8. ^ Dallol A, Agathanggelou A, Fenton SL, Ahmed-Choudhury J, Hesson L, Vos MD, Clark GJ, Downward J, Maher ER, Latif F (Jun 2004). "RASSF1A interacts with microtubule-associated proteins and modulates microtubule dynamics". Cancer Res. 64 (12): 4112–6. doi:10.1158/0008-5472.CAN-04-0267. PMID 15205320.

Further reading

  • Hammarback JA, Obar RA, Hughes SM, Vallee RB (1991). "MAP1B is encoded as a polyprotein that is processed to form a complex N-terminal microtubule-binding domain". Neuron. 7 (1): 129–39. doi:10.1016/0896-6273(91)90081-A. PMID 1712602. S2CID 34690111.
  • Schoenfeld TA, McKerracher L, Obar R, Vallee RB (1989). "MAP 1A and MAP 1B are structurally related microtubule associated proteins with distinct developmental patterns in the CNS". J. Neurosci. 9 (5): 1712–30. doi:10.1523/JNEUROSCI.09-05-01712.1989. PMC 6569839. PMID 2470876.
  • Avila J, Ulloa L, Diez-Guerra J, Diaz-Nido J (1994). "Role of phosphorylated MAPlB in neuritogenesis". Cell Biol. Int. 18 (5): 309–14. doi:10.1006/cbir.1994.1079. PMID 7519512. S2CID 85789590.
  • Lien LL, Feener CA, Fischbach N, Kunkel LM (1994). "Cloning of human microtubule-associated protein 1B and the identification of a related gene on chromosome 15". Genomics. 22 (2): 273–80. doi:10.1006/geno.1994.1384. PMID 7806212.
  • Ohyu J, Takashima S (1998). "Decreased expression of microtubule-associated protein 5 (MAP5) in the molecular layer of cerebellum in preterm infants with olivocerebellar lesions". Brain Dev. 20 (1): 22–6. doi:10.1016/S0387-7604(97)00088-0. PMID 9533556. S2CID 20265712.
  • Lucas FR, Goold RG, Gordon-Weeks PR, Salinas PC (1998). "Inhibition of GSK-3beta leading to the loss of phosphorylated MAP-1B is an early event in axonal remodelling induced by WNT-7a or lithium". J. Cell Sci. 111 ( Pt 10) (10): 1351–61. doi:10.1242/jcs.111.10.1351. PMID 9570753.
  • Tögel M, Wiche G, Propst F (1998). "Novel features of the light chain of microtubule-associated protein MAP1B: microtubule stabilization, self interaction, actin filament binding, and regulation by the heavy chain". J. Cell Biol. 143 (3): 695–707. doi:10.1083/jcb.143.3.695. PMC 2148156. PMID 9813091.
  • Hanley JG, Koulen P, Bedford F, Gordon-Weeks PR, Moss SJ (1999). "The protein MAP-1B links GABA(C) receptors to the cytoskeleton at retinal synapses". Nature. 397 (6714): 66–9. Bibcode:1999Natur.397...66H. doi:10.1038/16258. PMID 9892354. S2CID 4421437.
  • Jensen PH, Islam K, Kenney J, Nielsen MS, Power J, Gai WP (2000). "Microtubule-associated protein 1B is a component of cortical Lewy bodies and binds alpha-synuclein filaments". J. Biol. Chem. 275 (28): 21500–7. doi:10.1074/jbc.M000099200. PMID 10764738.
  • Tanner SL, Franzen R, Jaffe H, Quarles RH (2000). "Evidence for expression of some microtubule-associated protein 1B in neurons as a plasma membrane glycoprotein". J. Neurochem. 75 (2): 553–62. doi:10.1046/j.1471-4159.2000.0750553.x. PMID 10899930. S2CID 33325478.
  • Mei X, Sweatt AJ, Hammarback JA (2000). "Regulation of microtubule-associated protein 1B (MAP1B) subunit composition". J. Neurosci. Res. 62 (1): 56–64. doi:10.1002/1097-4547(20001001)62:1<56::AID-JNR6>3.0.CO;2-#. PMID 11002287. S2CID 196600490.
  • Billups D, Hanley JG, Orme M, Attwell D, Moss SJ (2000). "GABAC receptor sensitivity is modulated by interaction with MAP1B". J. Neurosci. 20 (23): 8643–50. doi:10.1523/JNEUROSCI.20-23-08643.2000. PMC 6773065. PMID 11102469.
  • Franzen R, Tanner SL, Dashiell SM, Rottkamp CA, Hammer JA, Quarles RH (2001). "Microtubule-associated protein 1B: a neuronal binding partner for myelin-associated glycoprotein". J. Cell Biol. 155 (6): 893–8. doi:10.1083/jcb.200108137. PMC 2150906. PMID 11733546.
  • Ding J, Liu JJ, Kowal AS, Nardine T, Bhattacharya P, Lee A, Yang Y (2002). "Microtubule-associated protein 1B: a neuronal binding partner for gigaxonin". J. Cell Biol. 158 (3): 427–33. doi:10.1083/jcb.200202055. PMC 2173828. PMID 12147674.
  • Dergunova LV, Raevskaya NM, Vladychenskaya IP, Limborska SA (2003). "Hmob3 brain-specific sequence is a part of phylogenetically conserved human MAP1B gene 3'-untranslated region". Biomol. Eng. 20 (3): 91–6. doi:10.1016/S1389-0344(03)00003-0. PMID 12684070.
  • Chang L, Jones Y, Ellisman MH, Goldstein LS, Karin M (2003). "JNK1 is required for maintenance of neuronal microtubules and controls phosphorylation of microtubule-associated proteins". Dev. Cell. 4 (4): 521–33. doi:10.1016/S1534-5807(03)00094-7. PMID 12689591.
  • Opal P, Garcia JJ, Propst F, Matilla A, Orr HT, Zoghbi HY (2003). "Mapmodulin/leucine-rich acidic nuclear protein binds the light chain of microtubule-associated protein 1B and modulates neuritogenesis". J. Biol. Chem. 278 (36): 34691–9. doi:10.1074/jbc.M302785200. PMID 12807913.


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