MNDA

Protein-coding gene in the species Homo sapiens
MNDA
Available structures
PDBHuman UniProt search: PDBe RCSB
List of PDB id codes

2DBG

Identifiers
AliasesMNDA, PYHIN3, myeloid cell nuclear differentiation antigen
External IDsOMIM: 159553 HomoloGene: 74438 GeneCards: MNDA
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for MNDA
Genomic location for MNDA
Band1q23.1Start158,831,351 bp[1]
End158,849,506 bp[1]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • monocyte

  • spongy bone

  • blood

  • bone marrow

  • periodontal fiber

  • germinal epithelium

  • bone marrow cells

  • spleen

  • palpebral conjunctiva

  • right lung
    n/a
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • DNA binding
  • protein binding
  • double-stranded DNA binding
Cellular component
  • cytoplasm
  • extracellular exosome
  • nucleus
  • extracellular region
  • nucleoplasm
  • nucleolus
  • azurophil granule lumen
  • ficolin-1-rich granule lumen
Biological process
  • B cell receptor signaling pathway
  • cellular defense response
  • regulation of transcription, DNA-templated
  • negative regulation of B cell proliferation
  • transcription, DNA-templated
  • cellular response to DNA damage stimulus
  • positive regulation of apoptotic process
  • neutrophil degranulation
  • activation of innate immune response
  • cellular response to interferon-beta
  • positive regulation of interleukin-1 beta production
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

4332

n/a

Ensembl

ENSG00000163563

n/a

UniProt

P41218

n/a

RefSeq (mRNA)

NM_002432

n/a

RefSeq (protein)

NP_002423

n/a

Location (UCSC)Chr 1: 158.83 – 158.85 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Myeloid cell Nuclear Differentiation Antigen is a protein that in humans is encoded as MNDA gene.[3][4][5]

Function

The myeloid cell nuclear differentiation antigen (MNDA) is detected only in nuclei of cells of the granulocyte-monocyte lineage. A 200-amino acid region of human MNDA is strikingly similar to a region in the proteins encoded by a family of interferon-inducible mouse genes, designated Ifi-201, Ifi202, and Ifi-203, that are not regulated in a cell- or tissue-specific fashion. The 1.8-kb MNDA mRNA, which contains an interferon-stimulated response element in the 5' UTR, was significantly upregulated in human monocytes exposed to interferon alpha. MNDA is located within 2,200 kb of FCER1A, APCS, CRP, and SPTA1. In its pattern of expression and/or regulation, MNDA resembles IFI16, suggesting that these genes participate in blood cell-specific responses to interferons.[5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000163563 - Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ Briggs JA, Burrus GR, Stickney BD, Briggs RC (May 1992). "Cloning and expression of the human myeloid cell nuclear differentiation antigen: regulation by interferon alpha". Journal of Cellular Biochemistry. 49 (1): 82–92. doi:10.1002/jcb.240490114. PMID 1644857. S2CID 84296063.
  4. ^ Briggs RC, Briggs JA, Ozer J, Sealy L, Dworkin LL, Kingsmore SF, Seldin MF, Kaur GP, Athwal RS, Dessypris EN (April 1994). "The human myeloid cell nuclear differentiation antigen gene is one of at least two related interferon-inducible genes located on chromosome 1q that are expressed specifically in hematopoietic cells". Blood. 83 (8): 2153–62. doi:10.1182/blood.V83.8.2153.2153. PMID 7512843.
  5. ^ a b "Entrez Gene: MNDA myeloid cell nuclear differentiation antigen".

Further reading

  • Burrus GR, Briggs JA, Briggs RC (February 1992). "Characterization of the human myeloid cell nuclear differentiation antigen: relationship to interferon-inducible proteins". Journal of Cellular Biochemistry. 48 (2): 190–202. doi:10.1002/jcb.240480210. PMID 1377701. S2CID 25290353.
  • Ott J, Fràter-Schröder M (1982). "Absence of linkage between transcobalamin II and ABO". Human Genetics. 59 (2): 164–5. doi:10.1007/BF00293068. PMID 7327575. S2CID 33911295.
  • Dawson MJ, Trapani JA, Briggs RC, Nicholl JK, Sutherland GR, Baker E (1995). "The closely linked genes encoding the myeloid nuclear differentiation antigen (MNDA) and IFI16 exhibit contrasting haemopoietic expression". Immunogenetics. 41 (1): 40–3. doi:10.1007/BF00188431. PMID 7806273. S2CID 12788123.
  • Briggs R, Dworkin L, Briggs J, Dessypris E, Stein J, Stein G, Lian J (February 1994). "Interferon alpha selectively affects expression of the human myeloid cell nuclear differentiation antigen in late stage cells in the monocytic but not the granulocytic lineage". Journal of Cellular Biochemistry. 54 (2): 198–206. doi:10.1002/jcb.240540208. PMID 8175894. S2CID 37002803.
  • Xie J, Briggs JA, Briggs RC (September 1998). "Human hematopoietic cell specific nuclear protein MNDA interacts with the multifunctional transcription factor YY1 and stimulates YY1 DNA binding". Journal of Cellular Biochemistry. 70 (4): 489–506. doi:10.1002/(SICI)1097-4644(19980915)70:4<489::AID-JCB6>3.0.CO;2-F. PMID 9712147. S2CID 42226327.
  • Doggett KL, Briggs JA, Linton MF, Fazio S, Head DR, Xie J, Hashimoto Y, Laborda J, Briggs RC (2002). "Retroviral mediated expression of the human myeloid nuclear antigen in a null cell line upregulates Dlk1 expression". Journal of Cellular Biochemistry. 86 (1): 56–66. doi:10.1002/jcb.10190. PMID 12112016. S2CID 30240885.
  • Fukushi M, Higuchi M, Oie M, Tetsuka T, Kasolo F, Ichiyama K, Yamamoto N, Katano H, Sata T, Fujii M (December 2003). "Latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus interacts with human myeloid cell nuclear differentiation antigen induced by interferon alpha". Virus Genes. 27 (3): 237–47. doi:10.1023/A:1026391715071. PMID 14618084. S2CID 1868558.
  • Briggs RC, Atkinson JB, Miranda RN (May 2005). "Variable expression of human myeloid specific nuclear antigen MNDA in monocyte lineage cells in atherosclerosis". Journal of Cellular Biochemistry. 95 (2): 293–301. doi:10.1002/jcb.20435. PMID 15778972. S2CID 39863400.
  • Asefa B, Dermott JM, Kaldis P, Stefanisko K, Garfinkel DJ, Keller JR (February 2006). "p205, a potential tumor suppressor, inhibits cell proliferation via multiple pathways of cell cycle regulation". FEBS Letters. 580 (5): 1205–14. doi:10.1016/j.febslet.2006.01.032. PMID 16458891. S2CID 21158774.
  • Briggs RC, Shults KE, Flye LA, McClintock-Treep SA, Jagasia MH, Goodman SA, Boulos FI, Jacobberger JW, Stelzer GT, Head DR (May 2006). "Dysregulated human myeloid nuclear differentiation antigen expression in myelodysplastic syndromes: evidence for a role in apoptosis" (PDF). Cancer Research. 66 (9): 4645–51. doi:10.1158/0008-5472.CAN-06-0229. PMID 16651415.
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  • 2dbg: Solution structure of the Pyrin (PAAD-DAPIN) domain in human Myeloid cell nuclear differentiation antigen
    2dbg: Solution structure of the Pyrin (PAAD-DAPIN) domain in human Myeloid cell nuclear differentiation antigen

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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(1) Basic domains
(1.1) Basic leucine zipper (bZIP)
(1.2) Basic helix-loop-helix (bHLH)
Group A
Group B
Group C
bHLH-PAS
Group D
Group E
Group F
bHLH-COE
(1.3) bHLH-ZIP
(1.4) NF-1
(1.5) RF-X
(1.6) Basic helix-span-helix (bHSH)
(2) Zinc finger DNA-binding domains
(2.1) Nuclear receptor (Cys4)
subfamily 1
subfamily 2
subfamily 3
subfamily 4
subfamily 5
subfamily 6
subfamily 0
(2.2) Other Cys4
(2.3) Cys2His2
(2.4) Cys6
(2.5) Alternating composition
(2.6) WRKY
(3) Helix-turn-helix domains
(3.1) Homeodomain
Antennapedia
ANTP class
protoHOX
Hox-like
metaHOX
NK-like
other
(3.2) Paired box
(3.3) Fork head / winged helix
(3.4) Heat shock factors
(3.5) Tryptophan clusters
(3.6) TEA domain
  • transcriptional enhancer factor
(4) β-Scaffold factors with minor groove contacts
(4.1) Rel homology region
(4.2) STAT
(4.3) p53-like
(4.4) MADS box
(4.6) TATA-binding proteins
(4.7) High-mobility group
(4.9) Grainyhead
(4.10) Cold-shock domain
(4.11) Runt
(0) Other transcription factors
(0.2) HMGI(Y)
(0.3) Pocket domain
(0.5) AP-2/EREBP-related factors
(0.6) Miscellaneous
see also transcription factor/coregulator deficiencies
Stub icon

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