MRS-1706

MRS-1706
Names
IUPAC name
N-(4-Acetylphenyl)-2-[4-(2,3,6,7-tetrahydro-2,6-dioxo-1,3-dipropyl-1H-purin-8-yl)phenoxy]acetamide
Other names
MRS 1706
Identifiers
CAS Number
  • 264622-53-9 checkY
3D model (JSmol)
  • Interactive image
ChemSpider
  • 4313008 ☒N
IUPHAR/BPS
  • 3287
MeSH C496145
PubChem CID
  • 5139184
UNII
  • YEE5LME5K5 checkY
CompTox Dashboard (EPA)
  • DTXSID40408687 Edit this at Wikidata
InChI
  • InChI=1S/C27H29N5O5/c1-4-14-31-25-23(26(35)32(15-5-2)27(31)36)29-24(30-25)19-8-12-21(13-9-19)37-16-22(34)28-20-10-6-18(7-11-20)17(3)33/h6-13H,4-5,14-16H2,1-3H3,(H,28,34)(H,29,30) ☒N
    Key: ZKUCFFYOQOJLGT-UHFFFAOYSA-N ☒N
  • InChI=1/C27H29N5O5/c1-4-14-31-25-23(26(35)32(15-5-2)27(31)36)29-24(30-25)19-8-12-21(13-9-19)37-16-22(34)28-20-10-6-18(7-11-20)17(3)33/h6-13H,4-5,14-16H2,1-3H3,(H,28,34)(H,29,30)
    Key: ZKUCFFYOQOJLGT-UHFFFAOYAX
  • CCCN1C2=C(C(=O)N(C1=O)CCC)NC(=N2)C3=CC=C(C=C3)OCC(=O)NC4=CC=C(C=C4)C(=O)C
Properties
Chemical formula
 C27H29N5O5
Molar mass 503.56
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
☒N verify (what is checkY☒N ?)
Infobox references
Chemical compound

MRS-1706 is a selective inverse agonist for the adenosine A2B receptor.[1] It inhibits release of interleukins and has an antiinflammatory effect.[2][3]

References

  1. ^ Li Q, Ye K, Blad CC, den Dulk H, Brouwer J, Ijzerman AP, Beukers MW (February 2007). "ZM241385, DPCPX, MRS1706 are inverse agonists with different relative intrinsic efficacies on constitutively active mutants of the human adenosine A2B receptor". The Journal of Pharmacology and Experimental Therapeutics. 320 (2): 637–45. doi:10.1124/jpet.106.111203. PMID 17077318.
  2. ^ Vazquez JF, Clement HW, Sommer O, Schulz E, van Calker D (May 2008). "Local stimulation of the adenosine A2B receptors induces an increased release of IL-6 in mouse striatum: an in vivo microdialysis study". Journal of Neurochemistry. 105 (3): 904–9. doi:10.1111/j.1471-4159.2007.05191.x. PMID 18088370.
  3. ^ Ryzhov S, Zaynagetdinov R, Goldstein AE, Novitskiy SV, Dikov MM, Blackburn MR, et al. (June 2008). "Effect of A2B adenosine receptor gene ablation on proinflammatory adenosine signaling in mast cells". Journal of Immunology. 180 (11): 7212–20. doi:10.4049/jimmunol.180.11.7212. PMC 3628765. PMID 18490720.
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Purine receptor modulators
Receptor
(ligands)
P0 (adenine)
P1
(adenosine)
P2
(nucleotide)
P2X
(ATPTooltip Adenosine triphosphate)
P2Y
Transporter
(blockers)
CNTsTooltip Concentrative nucleoside transporters
ENTsTooltip Equilibrative nucleoside transporters
PMATTooltip Plasma membrane monoamine transporter
Enzyme
(inhibitors)
XOTooltip Xanthine oxidase
Others
Others
See also: Receptor/signaling modulators


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