Mavacoxib
Veterinary drug
- QM01AH92 (WHO)
- 170569-88-7
- 9843089
- 8018804
- YFT7X7SR77
- CHEBI:76207
- DTXSID90168880
- Interactive image
- C1=CC(=CC=C1C2=CC(=NN2C3=CC=C(C=C3)S(=O)(=O)N)C(F)(F)F)F
InChI
- InChI=1S/C16H11F4N3O2S/c17-11-3-1-10(2-4-11)14-9-15(16(18,19)20)22-23(14)12-5-7-13(8-6-12)26(21,24)25/h1-9H,(H2,21,24,25)
- Key:TTZNQDOUNXBMJV-UHFFFAOYSA-N
Mavacoxib (trade name Trocoxil) is a veterinary drug used to treat pain and inflammation in dogs with degenerative joint disease.[1] It acts as a COX-2 inhibitor.[2]
Mavacoxib, along with other COX-2 selective inhibitors, celecoxib, valdecoxib, and parecoxib, were discovered by a team at the Searle division of Monsanto led by John Talley.[3][4]
References
- ^ European Public Assessment Report (EPAR): Trocoxil, European Medicines Agency
- ^ Cox SR, Lesman SP, Boucher JF, Krautmann MJ, Hummel BD, Savides M, et al. (October 2010). "The pharmacokinetics of mavacoxib, a long-acting COX-2 inhibitor, in young adult laboratory dogs". Journal of Veterinary Pharmacology and Therapeutics. 33 (5): 461–70. doi:10.1111/j.1365-2885.2010.01165.x. PMID 20840390.
- ^ Langreth R (June 23, 2003). "The Chemical Cobbler". Forbes.
- ^ "Dr. John Talley: 2001 St. Louis Awardee" (PDF). Chemical Bond. 52 (5). St. Louis Section, American Chemical Society: 2. May 2001. Archived from the original (PDF) on 15 April 2018.
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pyrazolidines
and related substances
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derivatives (profens)
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- Benoxaprofen†
- Carprofen‡
- Dexibuprofen
- Dexketoprofen
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- Fenoprofen
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- Ibuprofen#
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- COX-inhibiting nitric oxide donator: Naproxcinod
acids (fenamates)
(coxibs)
- Apricoxib
- Celecoxib (+tramadol)
- Cimicoxib‡
- Deracoxib‡
- Etoricoxib
- Firocoxib‡
- Lumiracoxib†
- Mavacoxib‡
- Parecoxib
- Robenacoxib‡
- Rofecoxib†
- Valdecoxib†
combinations
Key: underline indicates initially developed first-in-class compound of specific group; #WHO-Essential Medicines; †withdrawn drugs; ‡veterinary use.
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