Measles hemagglutinin

Hemagglutinin

Identifiers

Organism

Measles virus (strain Edmonston)

Symbol

PDB

2RKC

UniProt

P08362

Search for
Structures	Swiss-model
Domains	InterPro

Measles hemagglutinin is a hemagglutinin produced by measles virus.^[1]^[2]^[3]

It attaches to CD46 using a dead neuraminidase domain.^[4]^[5]

References

^ Pan CH, Jimenez GS, Nair N, et al. (August 2008). "Use of Vaxfectin adjuvant with DNA vaccine encoding the measles virus hemagglutinin and fusion proteins protects juvenile and infant rhesus macaques against measles virus". Clin. Vaccine Immunol. 15 (8): 1214–21. doi:10.1128/CVI.00120-08. PMC 2519314. PMID 18524884.
^ Tahara M, Takeda M, Shirogane Y, Hashiguchi T, Ohno S, Yanagi Y (May 2008). "Measles virus infects both polarized epithelial and immune cells by using distinctive receptor-binding sites on its hemagglutinin". J. Virol. 82 (9): 4630–7. doi:10.1128/JVI.02691-07. PMC 2293038. PMID 18287234.
^ Hashiguchi T, Kajikawa M, Maita N, et al. (December 2007). "Crystal structure of measles virus hemagglutinin provides insight into effective vaccines". Proc. Natl. Acad. Sci. U.S.A. 104 (49): 19535–40. Bibcode:2007PNAS..10419535H. doi:10.1073/pnas.0707830104. PMC 2148324. PMID 18003910.
^ Colf, LA; Juo, ZS; Garcia, KC (December 2007). "Structure of the measles virus hemagglutinin". Nature Structural & Molecular Biology. 14 (12): 1227–8. doi:10.1038/nsmb1342. PMID 18026116. S2CID 40292.
^ Nussbaum O, Broder CC, Moss B, Stern LB, Rozenblatt S, Berger EA (June 1995). "Functional and structural interactions between measles virus hemagglutinin and CD46". J. Virol. 69 (6): 3341–9. doi:10.1128/JVI.69.6.3341-3349.1995. PMC 189046. PMID 7745681.

Viral proteins (early and late)

DNA

linear ds-DNA
(Duplodnaviria,
Varidnaviria)

Herpes simplex

VSPs:

capsid:	HHV capsid portal protein Herpesvirus glycoprotein B

VNPs:

Vaccinia

VNPs:	B13R

Adenoviridae

VNPs:	E1A E1B

circular ds-DNA
(Duplodnaviria,
Varidnaviria?)

Epstein–Barr

VSPs:	LMP-1 LMP-2
VNPs:	EBNA-1 EBNA-2 EBNA-3
ncRNA:	EBER

Baculoviridae

VNPs:	Early 35 kDa protein

other
(Riboviria,
Monodnaviria)

Polyomaviridae
(SV40, MPyV, MCPyV, HaPyV)
(non-enveloped circular ds-DNA)

VSPs:

capsid:	VP1 VP2 and VP3

VNPs:

oncoprotein:	STag MTag LTag (SV40 Tag)

Agnoprotein

Hepatitis B
(circular partially ds-DNA)

VSPs:	HBsAg HBcAg HBeAg
VNPs:	HBx Hepatitis B virus DNA polymerase

RNA

ds-RNA
(Riboviria)

Rotavirus
(Duplornaviricota)

VNPs:	NSP1 NSP2 NSP3 NSP4 NSP5 NSP6

Rhinov., Polio, Hep A,
etc. (Pisuviricota)

VNPs:	VPg

ss-RNA
positive-sense
(Riboviria)

Hepatitis C
(Kitrinoviricota)

VSPs:	viral envelope E1 E2
VNPs:	P7 NS2 NS3 NS4A NS4B NS5A NS5B

SARS-CoV-2
(Pisuviricota)

VSPs:	viral envelope Spike Envelope Membrane Nucleocapsid
VNPs:	ORF1ab 3C-like protease (NS5) ORF3a ORF3b ORF3c ORF3d ORF6 ORF7a ORF7b ORF8 ORF9b

ss-RNA
negative-sense
(Negarnaviricota)

Influenza virus

VSPs:

capsid:	matrix protein M1 protein viral envelope M2 protein
glycoprotein:	Influenza hemagglutinin Neuraminidase HA-tag

VNPs:

Parainfluenza

VSPs:

glycoprotein:	Parainfluenza hemagglutinin-neuraminidase

Mumps

VSPs:

glycoprotein:	Mumps hemagglutinin-neuraminidase

Measles

VSPs:

glycoprotein:	Measles hemagglutinin

RSV

VSPs:

glycoprotein:	Respiratory syncytial virus G protein

Zaire ebolavirus

VSPs:

capsid:	matrix protein VP40 VP24

Indiana vesiculovirus

VSPs:

capsid:	matrix protein Vesiculovirus matrix proteins

Structure and genome of HIV

VSPs:	gag p24 pol Integrase Reverse transcriptase HIV-1 protease env gp120 gp41
VRAPs:	transactivators Tat Rev Vpr Nef Vif Vpu or Vpx