Meclorisone

Chemical compound
Meclorisone
Clinical data
Other namesNSC-92353; 16α-Methyldichlorisone; 9α,11β-Dichloro-17α,21-dihydroxy-16α-methylpregna-1,4-diene-3,20-dione
Drug classCorticosteroid; Glucocorticoid
Identifiers
  • (8S,9R,10S,11S,13S,14S,16R,17R)-9,11-Dichloro-17-hydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
CAS Number
  • 4732-48-3
PubChem CID
  • 260706
ChemSpider
  • 228830
UNII
  • K18P43Q80N
CompTox Dashboard (EPA)
  • DTXSID60197102 Edit this at Wikidata
Chemical and physical data
FormulaC22H28Cl2O4
Molar mass427.36 g·mol−1
3D model (JSmol)
  • Interactive image
  • C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@@]4([C@]3([C@H](C[C@@]2([C@]1(C(=O)CO)O)C)Cl)Cl)C
InChI
  • InChI=1S/C22H28Cl2O4/c1-12-8-16-15-5-4-13-9-14(26)6-7-19(13,2)21(15,24)17(23)10-20(16,3)22(12,28)18(27)11-25/h6-7,9,12,15-17,25,28H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,17+,19+,20+,21+,22+/m1/s1
  • Key:OKWSMPYQIYKVDC-CXSFZGCWSA-N

Meclorisone (developmental code name NSC-92353) is a synthetic glucocorticoid corticosteroid which was never marketed.[1]

References

  1. ^ Elks J (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 758–. ISBN 978-1-4757-2085-3.


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Glucocorticoid receptor modulators
GRTooltip Glucocorticoid receptor
Agonists
  • Nonsteroidal glucocorticoids: AZD-5423
  • GSK-9027
Mixed
(SEGRMsTooltip Selective glucocorticoid receptor agonists)
Antagonists
Others
  • Antisense oligonucleotides: IONIS-GCCRRx (ISIS-426115)
See also
Receptor/signaling modulators
Glucocorticoids and antiglucocorticoids
Mineralocorticoid receptor modulators
List of corticosteroids


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