Megazol

Chemical compound

None

Identifiers

IUPAC name

5-(1-methyl-5-nitro-1H-imidazol-2-yl)-1,3,4-thiadiazol-2-amine

CAS Number

19622-55-0^Y

ChemSpider

27598

UNII

VQ8UH664ZJ

CompTox Dashboard (EPA)

DTXSID50173298

Chemical and physical dataFormulaC₆H₆N₆O₂SMolar mass226.21 g·mol⁻¹3D model (JSmol)

Interactive image

SMILES

Cn1c(cnc1c2nnc(s2)N)[N+](=O)[O-]

Megazol (CL 64855) is a nitroimidazole based drug that cures some protozoan infections.

A study of nitroimidazoles found the drug extremely effective against T. cruzi and T. brucei which cause Chagas disease and African sleeping sickness, respectively. The drug is considerably more effective than standard benznidazole therapy (for Chagas) which is considered the gold standard.^[1] This is despite that other nitroimidazoles proved ineffective against these pathogens.^{[citation needed]}

References

^ Hall BS, Wilkinson SR (January 2012). "Activation of benznidazole by trypanosomal type I nitroreductases results in glyoxal formation". Antimicrobial Agents and Chemotherapy. 56 (1): 115–23. doi:10.1128/AAC.05135-11. PMC 3256028. PMID 22037852.