Mir-186 microRNA precursor family

Short RNA molecule

mir-186
Identifiers
Symbol	mir-186
Rfam	RF00697
miRBase family	14
Other data
RNA type	microRNA
Domain(s)	Eukaryota;
PDB structures	PDBe

In molecular biology mir-186 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms.

References

Babenko O, Golubov A, Ilnytskyy Y, Kovalchuk I, Metz GA (2012). Schönbach C (ed.). "Genomic and epigenomic responses to chronic stress involve miRNA-mediated programming". PLOS ONE. 7 (1): e29441. Bibcode:2012PLoSO...729441B. doi:10.1371/journal.pone.0029441. PMC 3265462. PMID 22291890.
Lv SQ, Kim YH, Giulio F, Shalaby T, Nobusawa S, Yang H, Zhou Z, Grotzer M, Ohgaki H (March 2012). "Genetic alterations in microRNAs in medulloblastomas". Brain Pathology. 22 (2): 230–9. doi:10.1111/j.1750-3639.2011.00523.x. PMC 8029025. PMID 21793975. S2CID 45910136.
Goeppert B, Schmezer P, Dutruel C, Oakes C, Renner M, Breinig M, Warth A, Vogel MN, Mittelbronn M, Mehrabi A, Gdynia G, Penzel R, Longerich T, Breuhahn K, Popanda O, Plass C, Schirmacher P, Kern MA (December 2010). "Down-regulation of tumor suppressor A kinase anchor protein 12 in human hepatocarcinogenesis by epigenetic mechanisms". Hepatology. 52 (6): 2023–33. doi:10.1002/hep.23939. PMID 20979053.
Zhang J, Du Y, Wu C, Ren X, Ti X, Shi J, Zhao F, Yin H (November 2010). "Curcumin promotes apoptosis in human lung adenocarcinoma cells through miR-186* signaling pathway". Oncology Reports. 24 (5): 1217–23. doi:10.3892/or_00000975. PMID 20878113.
Chen BZ, Yu SL, Singh S, Kao LP, Tsai ZY, Yang PC, Chen BH, Shoei-Lung Li S (January 2011). "Identification of microRNAs expressed highly in pancreatic islet-like cell clusters differentiated from human embryonic stem cells". Cell Biology International. 35 (1): 29–37. doi:10.1042/CBI20090081. PMID 20735361. S2CID 30538749.
Tang N, Zhang J, Du Y (April 2010). "[Curcumin promoted the apoptosis of cisplain-resistant human lung carcinoma cells A549/DDP through down-regulating miR-186*]". Zhongguo Fei AI Za Zhi = Chinese Journal of Lung Cancer. 13 (4): 301–6. doi:10.3779/j.issn.1009-3419.2010.04.06. PMC 6000427. PMID 20677554.
Zhang J, Zhang T, Ti X, Shi J, Wu C, Ren X, Yin H (August 2010). "Curcumin promotes apoptosis in A549/DDP multidrug-resistant human lung adenocarcinoma cells through an miRNA signaling pathway". Biochemical and Biophysical Research Communications. 399 (1): 1–6. doi:10.1016/j.bbrc.2010.07.013. PMID 20627087.
Wang KH, Kao AP, Singh S, Yu SL, Kao LP, Tsai ZY, Lin SD, Li SS (March 2010). "Comparative expression profiles of mRNAs and microRNAs among human mesenchymal stem cells derived from breast, face, and abdominal adipose tissues". The Kaohsiung Journal of Medical Sciences. 26 (3): 113–22. doi:10.1016/S1607-551X(10)70017-6. PMID 20227650.
Bostjancic E, Zidar N, Glavac D (2009). "MicroRNA microarray expression profiling in human myocardial infarction". Disease Markers. 27 (6): 255–68. doi:10.1155/2009/641082. PMC 3834671. PMID 20075508.
Myatt SS, Wang J, Monteiro LJ, Christian M, Ho KK, Fusi L, Dina RE, Brosens JJ, Ghaem-Maghami S, Lam EW (January 2010). "Definition of microRNAs that repress expression of the tumor suppressor gene FOXO1 in endometrial cancer". Cancer Research. 70 (1): 367–77. doi:10.1158/0008-5472.CAN-09-1891. PMC 2880714. PMID 20028871.
Vinuesa CG, Rigby RJ, Yu D (2009). "Logic and extent of miRNA-mediated control of autoimmune gene expression". International Reviews of Immunology. 28 (3–4): 112–38. doi:10.1080/08830180902934909. PMID 19811318. S2CID 23809860.
Zhang Y, Li M, Wang H, Fisher WE, Lin PH, Yao Q, Chen C (April 2009). "Profiling of 95 microRNAs in pancreatic cancer cell lines and surgical specimens by real-time PCR analysis". World Journal of Surgery. 33 (4): 698–709. doi:10.1007/s00268-008-9833-0. PMC 2933040. PMID 19030927.
Zhou L, Qi X, Potashkin JA, Abdul-Karim FW, Gorodeski GI (October 2008). "MicroRNAs miR-186 and miR-150 down-regulate expression of the pro-apoptotic purinergic P2X7 receptor by activation of instability sites at the 3'-untranslated region of the gene that decrease steady-state levels of the transcript". The Journal of Biological Chemistry. 283 (42): 28274–86. doi:10.1074/jbc.M802663200. PMC 2568908. PMID 18682393.
Zhou D, Li S, Wen J, Gong X, Xu L, Luo Y (February 2008). "Genome-wide computational analyses of microRNAs and their targets from Canis familiaris". Computational Biology and Chemistry. 32 (1): 60–5. doi:10.1016/j.compbiolchem.2007.08.007. PMID 18165158.