Mir-650 microRNA precursor family

mir-650
Identifiers
Symbol	mir-650
Rfam	RF00952
miRBase family	MIPF0000457
Other data
RNA type	microRNA
Domain(s)	Eukaryota;
PDB structures	PDBe

In molecular biology mir-650 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms.

Diabetic and Non-Diabetic Heart Failure

miR-650 is one of a group of six miRNAs with altered expression levels in diabetic and non-diabetic heart failure. This altered expression corresponds to various enriched cardiac dysfunctions.^[1]

NDRG2 regulation

miR-650 has further been reported to target a homologous DNA region in the promoter region of the NDRG2 gene.^[2] There is direct regulation of this gene at a transcriptional level, leading to repressed NDRG2 expression.

References

^ Greco S, Fasanaro P, Castelvecchio S, D'Alessandra Y, Arcelli D, Di Donato M, Malavazos A, Capogrossi MC, Menicanti L, Martelli F (June 2012). "MicroRNA dysregulation in diabetic ischemic heart failure patients". Diabetes. 61 (6): 1633–41. doi:10.2337/db11-0952. PMC 3357263. PMID 22427379.
^ Feng L, Xie Y, Zhang H, Wu Y (March 2011). "Down-regulation of NDRG2 gene expression in human colorectal cancer involves promoter methylation and microRNA-650". Biochemical and Biophysical Research Communications. 406 (4): 534–8. doi:10.1016/j.bbrc.2011.02.081. PMID 21352815.

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Zhang X, Zhu W, Zhang J, Huo S, Zhou L, Gu Z, Zhang M (April 2010). "MicroRNA-650 targets ING4 to promote gastric cancer tumorigenicity". Biochemical and Biophysical Research Communications. 395 (2): 275–80. doi:10.1016/j.bbrc.2010.04.005. PMID 20381459.
Das S (May 2009). "Evolutionary origin and genomic organization of micro-RNA genes in immunoglobulin lambda variable region gene family". Molecular Biology and Evolution. 26 (5): 1179–89. doi:10.1093/molbev/msp035. PMC 2727374. PMID 19246621.