Monalazone : Wikipedia, the free encyclopedia

Monalazone

Chemical compound

None

Identifiers

IUPAC name

4-(chlorosulfamoyl)benzoic acid

CAS Number

106145-03-3
61477-95-0 (disodium)

PubChem CID

68809

ChemSpider

62045

UNII

2UP9F49N8H

ChEMBL

ChEMBL2110958

CompTox Dashboard (EPA)

DTXSID70147532

Chemical and physical dataFormulaC₇H₆ClNO₄SMolar mass235.64 g·mol⁻¹3D model (JSmol)

Interactive image

SMILES

C1=CC(=CC=C1C(=O)O)S(=O)(=O)NCl

InChI

InChI=1S/C7H6ClNO4S/c8-9-14(12,13)6-3-1-5(2-4-6)7(10)11/h1-4,9H,(H,10,11)
Key:WGHSWNHOFPGMKJ-UHFFFAOYSA-N

Monalazone, used as monalazone disodium (INNTooltip International Nonproprietary Name; the disodium salt) and sold under the brand names Naclobenz-Natrium, Spergisin, and Speton, is a vaginal disinfectant or antiseptic and spermicidal contraceptive.^[1]^[2]^[3]^[4] It is a sulfonylbenzoic acid derivative and is closely related structurally to halazone.^[2] The compound was synthesized in 1937.^[1] A vaginal tablet combination of 0.125 mg estradiol benzoate and 10 mg monalazone was previously marketed under the brand name Malun 25.^[5]^[3]

References

^ ^a ^b Elks J (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 834–. ISBN 978-1-4757-2085-3.
^ ^a ^b Morton IK, Hall JM (31 October 1999). Concise Dictionary of Pharmacological Agents: Properties and Synonyms. Springer Science & Business Media. pp. 185–. ISBN 978-0-7514-0499-9.
^ ^a ^b Martindale W, Royal Pharmaceutical Society of Great Britain. Dept. of Pharmaceutical Sciences (1993). The Extra Pharmacopoeia. Pharmaceutical Press. p. 800. ISBN 978-0-85369-300-0. Monalazone disodium is an antiseptic closely related structurally to halazone (see p.796) and is used as a vaginal disinfectant and spermicide. Proprietary Names Malun N. Sperlisin. Multi-ingredient preparations. Malun.
^ RÖMPP Lexikon Chemie. Vol. 10. Auflage, 1996–1999. Thieme. 16 July 2014. pp. 2000–2001. ISBN 978-3-13-200031-5.
^ Leidenberger FA (17 April 2013). Klinische Endokrinologie für Frauenärzte. Springer-Verlag. pp. 527–. ISBN 978-3-662-08110-5.