Mucin 7

Protein-coding gene in the species Homo sapiens

MUC7

Identifiers

Aliases

MUC7, MG2, mucin 7, secreted

External IDs

OMIM: 158375 HomoloGene: 133350 GeneCards: MUC7

Gene location (Human)

Chr.	Chromosome 4 (human)^[1]

Band	4q13.3	Start	70,430,492 bp^[1]
Band	4q13.3	End	70,482,997 bp^[1]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

trachea

parotid gland

minor salivary glands

palpebral conjunctiva

amniotic fluid

tongue

right lung

superior surface of tongue

body of tongue

skin of abdomen

n/a

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	protein binding
Cellular component	Golgi lumen extracellular region extracellular exosome plasma membrane
Biological process	O-glycan processing stimulatory C-type lectin receptor signaling pathway antimicrobial humoral immune response mediated by antimicrobial peptide
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


4589


n/a

Ensembl


ENSG00000171195


n/a

UniProt


Q8TAX7


n/a

RefSeq (mRNA)


NM_152291 NM_001145006 NM_001145007


n/a

RefSeq (protein)


NP_001138478 NP_001138479 NP_689504


n/a

Location (UCSC)

Chr 4: 70.43 – 70.48 Mb

n/a

PubMed search

^[2]

n/a

Wikidata

View/Edit Human

Mucin-7 is a protein that in humans is encoded by the MUC7 gene.^[3]^[4] In animals, the MUC7 gene is found in most placental mammals, but not marsupials.^[5]

Human variations

Humans carry either a five or six tandem repeat version of the gene. In other primates, the number of repeats found is 4-5 for gorillas, 5 for chimpanzees, 6-7 for orangutans, 8-10 for macaques, 10-11 for baboons and 11-12 for green monkeys.^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000171195 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Bobek LA, Liu J, Sait SN, Shows TB, Bobek YA, Levine MJ (February 1996). "Structure and chromosomal localization of the human salivary mucin gene, MUC7". Genomics. 31 (3): 277–82. doi:10.1006/geno.1996.0049. PMID 8838308.
^ "Entrez Gene: MUC7 mucin 7, secreted".
^ ^a ^b Xu D, Pavlidis P, Thamadilok S, Redwood E, Fox S, Blekhman R, Ruhl S, Gokcumen O (August 2016). "Recent evolution of the salivary mucin MUC7". Scientific Reports. 6: 31791. Bibcode:2016NatSR...631791X. doi:10.1038/srep31791. PMC 4997351. PMID 27558399. This article contains quotations from this source, which is available under the Creative Commons Attribution 4.0 International (CC BY 4.0) license.

Zalewska A, Zwierz K, Zółkowski K, Gindzieński A (2002). "Structure and biosynthesis of human salivary mucins". Acta Biochimica Polonica. 47 (4): 1067–79. doi:10.18388/abp.2000_3960. PMID 11996097.
Bobek LA, Tsai H, Biesbrock AR, Levine MJ (September 1993). "Molecular cloning, sequence, and specificity of expression of the gene encoding the low molecular weight human salivary mucin (MUC7)". The Journal of Biological Chemistry. 268 (27): 20563–9. doi:10.1016/S0021-9258(20)80762-5. PMID 7690757.
Troxler RF, Iontcheva I, Oppenheim FG, Nunes DP, Offner GD (October 1997). "Molecular characterization of a major high molecular weight mucin from human sublingual gland". Glycobiology. 7 (7): 965–73. doi:10.1093/glycob/7.7.965. PMID 9363439.
Prakobphol A, Thomsson KA, Hansson GC, Rosen SD, Singer MS, Phillips NJ, Medzihradszky KF, Burlingame AL, Leffler H, Fisher SJ (April 1998). "Human low-molecular-weight salivary mucin expresses the sialyl lewisx determinant and has L-selectin ligand activity". Biochemistry. 37 (14): 4916–27. doi:10.1021/bi972612a. PMID 9538010.
Kirkbride HJ, Bolscher JG, Nazmi K, Vinall LE, Nash MW, Moss FM, Mitchell DM, Swallow DM (May 2001). "Genetic polymorphism of MUC7: allele frequencies and association with asthma". European Journal of Human Genetics. 9 (5): 347–54. doi:10.1038/sj.ejhg.5200642. PMID 11378823.
Guo JM, Zhang Y, Cheng L, Iwasaki H, Wang H, Kubota T, Tachibana K, Narimatsu H (July 2002). "Molecular cloning and characterization of a novel member of the UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase family, pp-GalNAc-T12". FEBS Letters. 524 (1–3): 211–8. doi:10.1016/S0014-5793(02)03007-7. PMID 12135769. S2CID 84453381.
Cheng L, Tachibana K, Zhang Y, Guo J, Kahori Tachibana K, Kameyama A, Wang H, Hiruma T, Iwasaki H, Togayachi A, Kudo T, Narimatsu H (November 2002). "Characterization of a novel human UDP-GalNAc transferase, pp-GalNAc-T10". FEBS Letters. 531 (2): 115–21. doi:10.1016/S0014-5793(02)03399-9. PMID 12417297. S2CID 221288147.
Banderas-Tarabay JA, Zacarías-D'Oleire IG, Garduño-Estrada R, Aceves-Luna E, González-Begné M (2003). "Electrophoretic analysis of whole saliva and prevalence of dental caries. A study in Mexican dental students". Archives of Medical Research. 33 (5): 499–505. doi:10.1016/S0188-4409(02)00395-8. PMID 12459324.
Wang H, Tachibana K, Zhang Y, Iwasaki H, Kameyama A, Cheng L, Guo J, Hiruma T, Togayachi A, Kudo T, Kikuchi N, Narimatsu H (January 2003). "Cloning and characterization of a novel UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase, pp-GalNAc-T14". Biochemical and Biophysical Research Communications. 300 (3): 738–44. doi:10.1016/S0006-291X(02)02908-X. PMID 12507512.
Soares RV, Siqueira CC, Bruno LS, Oppenheim FG, Offner GD, Troxler RF (June 2003). "MG2 and lactoferrin form a heterotypic complex in salivary secretions". Journal of Dental Research. 82 (6): 471–5. doi:10.1177/154405910308200613. PMID 12766201. S2CID 23276142.
Ge J, Catt DM, Gregory RL (November 2004). "Streptococcus mutans surface alpha-enolase binds salivary mucin MG2 and human plasminogen". Infection and Immunity. 72 (11): 6748–52. doi:10.1128/IAI.72.11.6748-6752.2004. PMC 523000. PMID 15501816.
Grys TE, Siegel MB, Lathem WW, Welch RA (March 2005). "The StcE protease contributes to intimate adherence of enterohemorrhagic Escherichia coli O157:H7 to host cells". Infection and Immunity. 73 (3): 1295–303. doi:10.1128/IAI.73.3.1295-1303.2005. PMC 1064933. PMID 15731026.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Bruno LS, Li X, Wang L, Soares RV, Siqueira CC, Oppenheim FG, Troxler RF, Offner GD (October 2005). "Two-hybrid analysis of human salivary mucin MUC7 interactions". Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1746 (1): 65–72. doi:10.1016/j.bbamcr.2005.08.007. PMID 16203048.
Li S, Intini G, Bobek LA (July 2006). "Modulation of MUC7 mucin expression by exogenous factors in airway cells in vitro and in vivo". American Journal of Respiratory Cell and Molecular Biology. 35 (1): 95–102. doi:10.1165/rcmb.2005-0305OC. PMC 2658701. PMID 16514118.

Protein, glycoconjugate: glycoproteins and glycopeptides

Mucoproteins

Mucin	CD43 CD164 MUC1 MUC2 MUC3A MUC3B MUC4 MUC5AC MUC5B MUC6 MUC7 MUC8 MUC12 MUC13 MUC15 MUC16 MUC17 MUC19 MUC20
Other	Haptoglobin Intrinsic factor Orosomucoid Peptidoglycan Phytohaemagglutinin Ovomucin

Proteoglycans

CS/DS	Decorin Biglycan Versican
HS/CS	Testican Perlecan
CS	Chondroitin sulfate proteoglycans: Aggrecan Neurocan Brevican CD44 CSPG4 CSPG5 Platelet factor 4 Structural maintenance of chromosomes 3
KS	Fibromodulin Lumican Keratocan
HS	Syndecan 1