NKX-homeodomain factor
Class of proteins
NKX-homeodomain factors are a family of homeodomain transcription factors that are critical regulators of organ development.[1]
Human genes that encode NKX-homeodomain factors include:
- NKX1-1, NKX1-2
- NKX2-1, NKX2-2, NKX2-4, NKX2-8
- NKX3-1, NKX3-2
- NKX6-1, NKX6-2, NKX6-3
References
- ^ Stanfel MN, Moses KA, Schwartz RJ, Zimmer WE (2005). "Regulation of organ development by the NKX-homeodomain factors: an NKX code". Cell. Mol. Biol. (Noisy-le-grand). Suppl 51: OL785–99. PMID 16405855.
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Transcription factors and intracellular receptors
(1) Basic domains | |||||||||||||||||||||||||
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(2) Zinc finger DNA-binding domains | |||||||||||||||||||||||||||
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(3) Helix-turn-helix domains | |||||||||||||||||||||
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(4) β-Scaffold factors with minor groove contacts | |||||||||||||||||||
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(0) Other transcription factors | |||||||||
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see also transcription factor/coregulator deficiencies